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Recent News and Articles on the Keywords: gehrig's disease + gene + mutation  Related to the article below (Last Update: 5/13/2008)

Yeast Has Potential For Selecting Lou Gehrig's Disease Drugs ...
Science Daily (press release) - Apr 17, 2008
The recent TDP-43 mutation studies confirm the protein's role in causing disease. The clumping process of proteins takes decades in humans but the ...

The Money Times
Congress passes anti-genetic discrimination bill
International Herald Tribune, France - May 1, 2008
That does not means that a disease will develop, researchers said, just that the person is more likely to get it than someone without the genetic mutation. ...
House passes ban on genetic discrimination Newsday
all 486 news articles »
Genetic Testing Bill Passed / House Vote is 414-1; Bans Using Data ...
RedOrbit, TX - May 6, 2008
That does not means that a disease will develop, researchers said, just that the person is more likely to get it than someone without the mutation. ...

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… in the VMD2 gene are associated with juvenile-onset vitelliform macular dystrophy (Best disease) … -
… , K White, D Pauleikhoff, A Gehrig, L Passmore, A … - Hum Genet, 2000 - retinascience.de
... In all these probands peripherin/RDS was excluded as the disease-causing gene prior
to the mutation analysis in the VMD2 gene.28 Similar to our findings in ...

Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus … -
… Bartoloni, JL Blouin, Y Pan, C Gehrig, AK Maiti, N … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences
... Louis Blouin * , Yanzhen Pan , Corinne Gehrig * , Amit K ... transmembrane conductance
regulator (CFTR) gene (16) was ... The respiratory disease had an earlier age of ...

Positional cloning of the gene associated with X-linked juvenile retinoschisis -
CG Sauer, A Gehrig, R Warneke-Wittstock, A … - Nature Genetics, 1997 - nature.com
... Christian G. Sauer 1, * , Andrea Gehrig 1, * , Regina ... missense mutations segregating
with the disease phenotype in ... evidence that the XLRS1 gene, when mutated ...

Insights into Lou Gehrig's Disease from the Structure and Instability of the A4V Mutant of Human Cu, … -
RMF Cardoso, MM Thayer, M DiDonato, TP Lo, CK … - Journal of Molecular Biology, 2002 - Elsevier
... lateral sclerosis (FALS), also called Lou Gehrig's disease.[6 and ... increase in abundance
as the disease progresses. ... at codon 126 of the HSOD gene demonstrated co ...

Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the … -
TJ Lyons, H Liu, JJ Goto, A Nersissian, JA Roe, JA … - Proceedings of the National Academy of Sciences of the …, 1996 - pubmedcentral.nih.gov
... lateral sclerosis (ALS; also known as Lou Gehrig's disease). ... same gain of function
that causes the disease. ... in Cu/Zn superoxide dismutase gene are associated ...

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS -
DW Cleveland, JD Rothstein - Nat Rev Neurosci, 2001 - lifesci.sussex.ac.uk
... FROM CHARCOT TO LOU GEHRIG: ... of each of these factors in sporadic and familial disease,
and dis- cuss the discovery of a second gene ? a putative GUANINE ...

DNA/RNA Helicase Gene Mutations in a Form of Juvenile Amyotrophic Lateral Sclerosis (ALS4) -
YZ Chen, CL Bennett, HM Huynh, IP Blair, I Puls, J … - The American Journal of Human Genetics, 2004 - Elsevier
... Amyotrophic lateral sclerosis (ALS), also known as ?Lou Gehrig?s disease,? denotes
a ... in the Cu/Zn superoxide dismutase (SOD1) gene on chromosome 21q21 ...

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral … -
DR Rosen, T Siddique, D Patterson, DA Figlewicz, P … - Nature, 1993 - Mass Med Soc
... Amyotrophic lateral sclerosis (ALS) -- the disease affecting Lou Gehrig and Stephen ...
research team reports finding mutations of a gene on chromosome ...

Parkinson disease: etiology, pathogenesis and future of gene therapy -
BS Shastry - Neuroscience Research, 2001 - Elsevier
... lateral sclerosis (also called Lou Gehrig's disease) is associated ... may be responsible
for disease but maternal ... in the altered state (because of gene a mutation ...

The molecular basis of copper-transport diseases -
JFB Mercer - Trends in Molecular Medicine, 2001 - Elsevier
... 3. LM Klevay, Cardiovascular disease from copper deficiency ? a history. ... 5. K. Yoshida
et al., A mutation in the ceruloplasmin gene is associated with ...

Source: Google Scholar

Mutation in one gene tied to Lou Gehrig's disease

Last Updated: 2007-12-17 11:26:51 -0400 (Reuters Health)

CHICAGO - A mutation in a single gene may raise one's risk of developing amyotrophic lateral sclerosis (ALS), also know as Lou Gehrig's disease, by as much as 30 percent, offering a potential new target for drug research, Dutch scientists said on Sunday.

They said a variant in the DPP6 gene may give rise to ALS in people without a family susceptibility to the untreatable and fatal disease.

Familial ALS, which accounts for 10 percent of all cases of the disease, has been linked with mutations in a number of other genes. Researchers have had less luck finding a gene associated with non-familial, sporadic ALS, which accounts for 90 percent of ALS cases.

But researchers at the University Medical Center Utrecht said a SNP or single-letter change in the genetic code of the DPP6 gene is "consistently and strongly associated with susceptibility to amyotrophic lateral sclerosis in different populations of European ancestry."

The DPP6 gene controls an enzyme found mostly in the brain that has been linked with spinal cord injury in rats.

Leonard van den Berg and a team of researchers used a new approach called a genome-wide association study to comb through the genetic code of 1,700 individuals with the disease, and compared that to the genome of more than 1,900 healthy people.

The samples came from three European populations and recently reported data from ALS patients in the United States.

What they discovered was a single variant in DPP6 that was associated with ALS in each population. This variant increased the risk of getting the disease by about 30 percent.

The researchers said this is the first genetic risk factor found consistently across many populations.

"Identification of a common variant within DPP6 is an exciting first step in the genetic study of sporadic ALS, and it opens up new avenues for studying the molecular basis of this devastating disease," van den Berg and colleagues wrote in the journal Nature Genetics.

ALS progressively kills nerve cells that control muscle movements known as motor neurons in the brain and spinal cord. It is sometimes called Lou Gehrig's disease for taking the life of the famous New York Yankees baseball player in 1941.

About 5,600 people in the United States are diagnosed with ALS each year, according to the ALS Association.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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