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Recent News and Articles on the Keywords: breast cancer + in brain + combination  Related to the article below (Last Update: 5/13/2008)


Daily Mail
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Daily Mail, UK -
In a survey of 266000 women by the prestigious Fred Hutchinson Cancer Research Centre in Seattle, the death rate from breast cancer was the same in the ...
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WBOY-TV, WV -
Researchers say adult women who were breast-fed as infants have an almost 20 percent lower risk of developing breast cancer. But they did not find this ...
New health center opens
North County Times, CA - May 11, 2008
Dr. Michele Carpenter, a breast cancer surgeon, and Lynn Larkin Flanagan, an 11-year breast cancer survivor, will discuss breast cancer. ...
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Medical News Today (press release), UK - May 9, 2008
This is the third major clinical trial of BSI-201 that BiPar has launched in the past 6 months, expanding on on going trials in breast and brain cancer. ...

Alalam News Network
'Chemo brain' real for many cancer patients: study
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dBTechno
New Data Demonstrate That Lapatinib Decreases Tumourigenic Breast ...
Medical News Today (press release), UK - Apr 18, 2008
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GlaxoSmithKline says Tykerb study shows potential in metastases MarketWatch
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Natural News.com
Folate and Vitamin B-12: Two Nutrients Critical for Brain Health
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As multiple other previous studies have shown, and as I and other breast cancer experts have warned for years, the use of HRT (and combination HRT in ...

The Money Times
Pfizer, Avant Ink R&D Deal for Cancer Vaccine
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Source: Google News

… hour infusion in combination with bolus doxorubicin in women with untreated metastatic breast cancer -
L Gianni, E Munzone, G Capri, F Fulfaro, E Tarenzi … - Journal of Clinical Oncology, 1995 - jco.ascopubs.org
... Paclitaxel by 3-hour infusion in combination with bolus doxorubicin in women with
untreated metastatic breast cancer: high antitumor efficacy and cardiac ...

Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases -
A Pirzkall, J Debus, F Lohr, M Fuss, B Rhein, R … - Journal of Clinical Oncology, 1998 - jcojournal.org
... metastases when used alone or in combination with WBRT. ... for One to Three Newly Diagnosed
Brain Metastases From ... EP Winer CNS Metastases in Breast Cancer J. Clin ...

… Oral Bioavailability of Topotecan in Combination With the Breast Cancer Resistance Protein and P- … -
CMF Kruijtzer, JH Beijnen, H Rosing, WW ten Bokkel … - Journal of Clinical Oncology, 2002 - jco.ascopubs.org
... Patients with symptomatic brain metastases were not eligible ... Phase I and pharmacologic
study of the combination of paclitaxel ... from human MCF-7 breast cancer cells ...

… With CMFP Combination Chemotherapy as Front-Line Therapy in Untreated Metastatic Breast Cancer -
JF Bishop, J Dewar, GC Toner, J Smith, MHN … - Journal of Clinical Oncology, 1999 - jcojournal.org
... of or current malignancy other than breast cancer, except nonmelanoma skin cancer
or carcinoma-in ... 2 or worse neuropathy, proven brain metastasis as ...

Chemotherapy induces regression of brain metastases in breast carcinoma -
D Rosner, T Nemoto, WW Lane - Cancer, 1986 - doi.wiley.com
... TABLE 3. Brain Metastases From Breast Cancer in 100 ... response to initial chemotherapy
for brain metastases between ... as a five-drug combination chemotherapy (CFPMV ...

Combination Therapy with Platinum and Etoposide of Brain Metastases from Breast Carcinoma -
G Cocconi, R Lottici, G Bisagni, M Bacchi, M … - Cancer Investigation, 1990 - informaworld.com
... in pa- tients with Stage IV breast cancer (8,9 ... results obtained in a few patients
with brain lesions prompted ... Phase I1 study in which this combination was used ...

… nervous system progression among patients with metastatic breast cancer responding to trastuzumab … -
E Shmueli, N Wigler, M Inbar - European Journal of Cancer, 2004 - Elsevier
... two other patients, trastuzumab in combination with weekly ... additional trastuzumab
without evidence of brain relapse or ... in 10?15% of breast cancer patients [6 ...

Brain metastases in breast cancer; natural history, prognostic factors and outcome -
W Boogerd, VW Vos, AAM Hart, G Baris - Journal of Neuro-Oncology, 1993 - Springer
... patients with adenocarcinoma of the breast in whom ... computer files of the Netherlands
Cancer Institute/Antoni ... scan findings char- acteristic of brain metastasis ...

… in Combination With Paclitaxel and Carboplatin in Advanced Non-Small-Cell Lung Cancer: A Phase III … -
RS Herbst, G Giaccone, JH Schiller, RB Natale, V … - Journal of Clinical Oncology, 2004 - jco.ascopubs.org
... global trial that evaluated the combination of gefitinib ... NSCLC or small-cell lung
cancer, brain metastases that ... times ULRR, pregnancy or breast-feeding, and ...

… Alone or in Combination with Chemotherapy in the Treatment of HER2-Positive Metastatic Breast Cancer -
J Baselga, J Baselga - Logo, 2001 - content.karger.com
... 1999]; and a phase III combination trial comparing ... patients with HER2-positive
metastatic breast cancer [Mass et ... for the following reasons: brain metastases (n ...

Source: Google Scholar

Drug combination shrinks breast cancer metastases in brain

SAN ANTONIO, Texas--A combination of a "targeted" therapy and chemotherapy shrank metastatic brain tumors by at least 50 percent in one-fifth of patients with aggressive HER2-positive breast cancer, according to data presented by Dana-Farber Cancer Institute investigators at the San Antonio Breast Cancer Symposium.

Lapatinib (Tykerb) and capecitabine (Xeloda) were paired in an extension of a Phase 2 clinical trial in which lapatinib given alone shrank brain metastases significantly in six percent of 241 patients.

In the extension trial, capecitabine was added to lapatinib in 49 patients whose metastases -- cancerous colonies in the brain spread from their primary cancer -- had progressed while on treatment. With the combination therapy, brain metastases shrank by 20 percent or more in 18 patients (37 percent) and shrank by at least 50 percent in 10 patients (20 percent), reported Nancy Lin, MD, of Dana-Farber's Breast Oncology Center.

"Very few medications have shown activity in the treatment of brain metastases, particularly in HER-2-positive metastatic breast cancer patients," said Lin, who led the study with Eric Winer, MD, director of the Dana-Farber Breast Oncology Center. "Therefore, these data are quite encouraging, and further studies are warranted."

The data (abstract 6076) will be presented on Sunday, Dec. 16 at 7 a.m. CT.

Lapatinib is an oral small-molecule drug from GlaxoSmithKline that is approved along with capecitabine for treating patients with advanced or metastatic breast cancer whose tumors are driven by the abnormal growth signal, HER-2, and who have already undergone therapy including trastuzumab (Herceptin), a taxane drug, and an anthracycline compound. Lapatinib, like trastuzumab, blocks the HER-2 signal.

Up to one-third of women with advanced, HER-2-positive breast cancer may develop metastases to the brain.

"Although radiation treatment is often effective, as women live longer with metastatic cancer, some develop worsening of brain metastases despite radiation," said Lin. "Because cancer in the brain can have a major impact on quality of life, it is important to have treatment options to address this problem."

###

The study was sponsored in part by GlaxoSmithKline.

Dana-Farber Cancer Institute (www.dana-farber.org) is a principal teaching affiliate of the Harvard Medical School and is among the leading cancer research and care centers in the United States. It is a founding member of the Dana-Farber/Harvard Cancer Center (DF/HCC), designated a comprehensive cancer center by the National Cancer Institute.

 
 
 
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