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Recent News and Articles on the Keywords: growth hormone + fibromyalgia pain + fibromyalgia  Related to the article below (Last Update: 5/13/2008)

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… C in patients with the fibromyalgia syndrome. A possible link between sleep and muscle pain. -
RM Bennett, SR Clark, SM Campbell, CS Burckhardt - Arthritis Rheum, 1992 - ncbi.nlm.nih.gov
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GA McCain, KS Tilbe - J Rheumatol Suppl, 1989 - ncbi.nlm.nih.gov
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Impaired growth hormone secretion in fibromyalgia patients -
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RM Bennett - Mayo Clin Proc, 1999 - mayoclinicproceedings.com
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-

Current Concepts in the Pathophysiology of Abnormal Pain Perception in Fibromyalgia. -
DA WEIGENT, LA BRADLEY, JE BLALOCK, GS ALARCON - The American Journal of the Medical Sciences, 1998 - amjmedsci.com
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Management of Fibromyalgia Syndrome -
DL Goldenberg, C Burckhardt, L Crofford - JAMA, 2004 - Am Med Assoc
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… Hormone (GH)-Releasing Hormone-GH-Insulin-like Growth Factor-1 Axis in Patients with Fibromyalgia … -
A Leal-Cerro, J Povedano, R Astorga, M Gonzalez, H … - Journal of Clinical Endocrinology & Metabolism, 1999 - Endocrine Soc
... 1995 Fibromyalgia: the commonest cause of widespread pain. ... like growth factor-1 and
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Hypothalamic-pituitary-insulin-like growth factor-I axis dysfunction in patients with fibromyalgia. -
RM Bennett, DM Cook, SR Clark, CS Burckhardt, SM … - J Rheumatol, 1997 - ncbi.nlm.nih.gov
... I (IGF-I) in patients with fibromyalgia (FM) compared ... blood donors, 26 myofascial
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Management of Fibromyalgia -
LJ Leventhal - Annals of Internal Medicine, 1999 - annals.highwire.org
... tender point injections show promise in the management of pain associated with
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The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia -
DJ Claliw - Medical Hypotheses, 1995 - Elsevier
... enti- ties (IBS, noncardiac chest pain, interstitial cystitis ... in IGF-1 synthesis
in fibromyalgia is likely due ... to an elevation in growth hormone (and therefore ...

Source: Google Scholar

Growth hormone may curb fibromyalgia pain

Last Updated: 2007-12-14 13:30:27 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Some people who suffer from a common and often debilitating chronic pain condition called fibromyalgia may find relief with shots of growth hormone, a study hints.

In a group of patients with severe fibromyalgia and low blood levels of insulin-like growth factor 1 (IGF-1), adding daily injections of growth hormone to standard intensive therapy reduced pain and improved quality of life, researchers found.

There is evidence of growth hormone deficiency -- expressed as low IGF-1 blood levels -in some fibromyalgia patients, Dr. Guillem Cuatrecasas at Centro Medico Teknon in Barcelona, and colleagues explain in a report published online. Growth hormone stimulates IGF-1 in the body.

The Spanish investigators studied the effects of growth hormone in a study involving 24 mostly female patients who had severe fibromyalgia lasting at least 1 year, low IGF-1 levels, and pain in at least 16 of the 18 fibromyalgia "trigger points."

Standard therapy included an antidepressant, such as amitriptyline or fluoxetine, plus the painkiller tramadol, as well as active rehabilitation and psychological support.

Twelve patients were randomly selected for treatment with human growth hormone.

After 12 months, the number of tender points was significantly lower in the growth hormone group (average 6.50 versus 16.5), the investigators report.

Growth hormone treatment was also associated with significantly greater improvement in scores on the so-called Fibromyalgia Impact Questionnaire and in overall quality of life.

In fact, all 12 patients in the growth hormone group experienced global improvement, which was apparent within the first month according to most measurements. Improvements were evident in areas such as fatigue, pain, anxiety and depression, the investigators note.

"The consistency and magnitude of these results...are encouraging and warrant further validation in a multicenter, double-blind confirmatory study, which is currently ongoing."

SOURCE: BMC Musculoskeletal Disorders, online November 30. 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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