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Recent News and Articles on the Keywords: fracture risk + asthma drugs + risk  Related to the article below (Last Update: 5/5/2008)

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Source: Google News

… density and the risk of fracture in patients receiving long-term inhaled steroid therapy for asthma … -
JH Toogood, JC Baskerville, AE Markov, AB Hodsman, … - J Allergy Clin Immunol, 1995 - ncbi.nlm.nih.gov
... To determine whether high-dose or prolonged inhaled steroid therapy for asthma
increases a patient's risk of osteoporosis and fracture, we measured bone ...

Inhaled Corticosteroids and Hip Fracture: A Population-based Case-Control Study -
RB Hubbard, CJP Smith, L Smeeth, TW Harrison, AE … - American Journal of Respiratory and Critical Care Medicine, 2002 - 171.66.122.149
... Psychotropic drug use and the risk of hip fracture. ... C. Use of inhaled corticosteroids
and risk of fractures ... density and bone metabolism in patients with asthma. ...

Use of Inhaled Corticosteroids and Risk of Fractures -
TP Van Staa, HGM Leufkens, C Cooper - Journal of Bone and Mineral Research, 2001 - Am Soc Bone Min Res
... RG, Drost D 1995 Bone mineral density and the risk of fracture in patients ... 2000 Inhaled
corticosteroid use and bone mineral density in patients with asthma. ...

Use of Oral Corticosteroids and Risk of Fractures -
TP Van Staa, HGM Leufkens, L Abenhaim, B Zhang, C … - Journal of Bone and Mineral Research, 2000 - Am Soc Bone Min Res
... arthritis: An evaluation of associated risk factors ... fractures and bone loss In patients
with asthma.. ... substantially underestimate the anti-fracture effects of ...

Oral corticosteroids and fracture risk: relationship to daily and cumulative doses -
TP van Staa, HGM Leufkens, L Abenhaim, B Zhang, C … - Rheumatology, 2000 - Br Soc Rheumatology
... and peripheral bone mineral content and fracture incidence in ... fractures and bone
loss in patients with asthma. ... Use of oral corticosteroids and risk of fractures ...

Identifying Bone-Mass-Related Risk Factors for Fracture to Guide Bone Densitometry Measurements: A … -
M Espallargues, L Sampietro-Colom, MD Estrada, M … - Osteoporosis International, 2001 - Springer
... Very few studies addressing the effect of drugs on the risk of fracture were identified;
corticosteroids and thiazide diuretics were the most frequently studied ...

Fracture risk associated with systemic and topical corticosteroids -
P VESTERGAARD, L REJNMARK, L MOSEKILDE - Journal of Internal Medicine, 2005 - Blackwell Synergy
... may be registered, and not all drugs ingested may ... of other diagnoses (COPD, asthma,
haematological disorders ... The association between fracture risk and inhaled ...

Severity of obstructive airway disease and risk of osteoporotic fracture -
F de Vries, TP van Staa, M Bracke, C Cooper, HGM … - European Respiratory Journal, 2005 - ersj.org.uk
... for this possible relationship between OAD and increased risk of fracture or
osteoporosis ... that are expressed in inflammatory diseases, such as asthma and/or ...

Are inhaled corticosteroids associated with an increased risk of fracture in children? -
TP van Staa, N Bishop, HGM Leufkens, C Cooper - Osteoporosis International, 2004 - Springer
... use that have been associated in adults with risk of fracture [2]. Variables ... recent
and past use of bronchodilators, hospitalisation for asthma during the 2 ...

… intravenous ibandronate injections reduce vertebral fracture risk in corticosteroid-induced … -
JD Ringe, A Dorst, H Faber, K Ibach, F Sorenson - Osteoporosis International, 2003 - Springer
... Vertebral fractures in steroid dependent asthma and involutional ... Drugs Aging
4:449)461 28 ... 2002) Oral ibandronate significantly reduces fracture risk in postmeno ...

Source: Google Scholar

Asthma drugs not linked to fracture risk: study

Last Updated: 2007-12-14 12:27:57 -0400 (Reuters Health)

By Will Boggs, MD

NEW YORK (Reuters Health) - Inhaled and oral bronchodilators do not appear to increase the risk of fracture in people with chronic lung disease, according to Danish investigators who suggest that the "severity of the underlying lung disease" may be responsible.

"Inhaled drugs are safe; therefore, the focus should be on preventing use of large doses of oral corticosteroids for prolonged periods of time," Dr. Peter Vestergaard from Aarhus University Hospital, told Reuters Health. These patients "may perhaps better be managed with the inhaled preparations in terms of bone safety," he added.

Vestergaard and colleagues investigated whether the use of any bronchodilator or other lung active drug for asthma, COPD (chronic obstructive pulmonary disease), emphysema, or other lung disease was associated with a change in the risk of fractures in nearly 250,000 patients residing in Denmark in 2000. Each patient was matched with three controls from the general population.

The risk of fracture was higher in patients with COPD, emphysema, and other chronic lung disease than in patients with asthma, they report in the journal Chest.

There was a "dose-dependent" relationship between oral steroids and an increased fracture risk, the report indicates, but no other drugs were associated with fracture risk.

There was also an increased risk of fracture associated with inhaled short-acting beta-agonists, but, the investigators say, this increased risk is likely associated with the severity of the underlying lung disease for which the drugs are administered.

"Focus needs to be maintained on the bone health of patients with lung disease," Vestergaard advised.

SOURCE: Chest, November 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 

 

 

 

 

 
 
 
 
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