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Recent News and Articles on the Keywords: side effects + show promise + anastrozole  Related to the article below (Last Update: 5/5/2008)

Cancer-drug trials show promise
Arizona Republic, AZ - Apr 15, 2008
"I think this fulfills the promise of what targeted therapies can do, with dramatic effects and low side effects." The second clinical trial studied how the ...
New Therapies Show Promise For Fighting Basal Cell Carcinoma And ...
Science Daily (press release) - Apr 18, 2008
In the first trial, a novel molecule, GDC-0449, shrinks tumors in basal cell carcinoma (BCC) while having limited side effects, including a loss of sense of ...

Ars Technica
Overcoming a synthetic obstacle for testing HIV drugs
Ars Technica, MA -
This sort of prolonged period of therapy is likely to have many adverse side effects, ranging from the emergence of drug resistance to increased financial ...
Ness Technologies, Inc. Q1 2008 Earnings Call Transcript
Seeking Alpha, NY -
Ofer will discuss the effects of the foreign exchange on our business later in the call. Nevertheless, our business remains strong, we are adjusting to the ...NSTC
Fox Western Classics
DVD Talk, OR - May 2, 2008
The effects men even add a stop motion animation shot, when one unlucky Apache take an unscheduled plunge down the painted cliff side. ...
Four great pretenders
Irish Independent, Ireland - May 4, 2008
After that, you find Derry, the league champions, whose lengthier odds are attributable to the likely jaded effects of a tour through Ulster. ...
Test vaccine offers hope for brain cancer sufferers
Monterey County Herald, CA - May 2, 2008
She did not suffer other side effects, such as slurred speech or blurred vision. She is able to drive a car on short trips, but is not yet ready to return ...

Rocky Mountain News
Waters plays with passion, purpose
Rocky Mountain News, CO - Apr 30, 2008
With the promise of the entirety of the Dark Side of the Moon album, the crowd was expectant. That, however, was for the second half of the show. ...
Fashion Week Cleveland -- Glam Party
The Plain Dealer - cleveland.com, OH - May 3, 2008
Regardless, it seems some folks in Cleveland have discovered the softer side of Sears. (Ladies, may I enter a plea? Let the record show that I am wildly ...
Reprise time: Summer offers Indy, Batman, Narnia, X-Files
The Associated Press - Apr 25, 2008
I believed in all the promise and potential that New York offered,'" Parker said. "It's not like a slumber party in sweats, anymore. ...
Source: Google News

Management of menopausal symptoms in patients with breast cancer: an evidence-based approach -
M Hickey, CM Saunders, BGA Stuckey - Lancet Oncology, 2005 - Elsevier
... generally tolerated well, but side-effects include gastrointestinal ... secondary to
the effects of higher ... Behavioural interventions show promise, but have not yet ...

[PDF] Chemoprevention of breast cancer: current status and future prospects -
X Zhao, L Li, Z Wang - Front Biosci, 2006 - bioscience.org
... It was estimated that anastrozole treatment might prevent ... as well as fewer side effects,
which can ... Moreover tea polyphenols show promise in preventing estrogen ...

Chemoprevention Clinical Trials: It Is Time to Turn Success into Progress -
PH Brown - Cancer Epidemiology Biomarkers & Prevention, 2007 - AACR
... and sometimes serious, side effects, the promise of chemoprevention ... they are also
needed to show the magnitude ... based on having fewer side effects than tamoxifen ...

Aromatase inhibitors continue their ATAC on tamoxifen -
H Nicholls - Trends in Molecular Medicine, 2002 - Elsevier
... have estrogen-positive tumours, the promise of aromatase ... the Royal Marsden: ?the
side-effects [of aromatase ... Baltimore (Baltimore, MD, USA), show no obvious ...

[PDF] Tamoxifen alternatives show promise in early breast cancer treatment
I Cases, A Board - thomasmaymedicalwriter.com
... for Oncology - Tamoxifen alternatives show promise in early ... an increased incidence
of musculoskeletal side effects, but a ... breast cancer to anastrozole after 2 ...

Breast cancer: New strategies to beat an old enemy. -
ML WORKMAN - Nursing, 2002 - nursing2004.com
... to achieve better cancer cell kill with fewer side effects. ... of drugs that have
antiestrogen effects on estrogen ... on other types of cells show promise for wider ...
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Fluorine in medicinal chemistry: A review of anti-cancer agents -
C Isanbor, DO?Hagan - Journal of Fluorine Chemistry, 2006 - Elsevier
... in tamoxifen-resistant disease and show no superiority over ... are characterized by
an alkylamine side-chain at ... receptor antagonist with no agonist effects and it ...

[PDF] Cancer Chemoprevention: Progress and Promise -
SM Lippman, JJ Lee, AL Sabichi - jnci, 1998 - jnci.oxfordjournals.org
... angiogenesis inhibitors and ras inhibitors, also show activity and promise in both ...
of risks for certain adverse tamoxifen side effects, are discussed ...
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Adjuvant therapy for postmenopausal ER-positive breast cancer. Why tamoxifen still has a future? The … -
P NEVEN, R PARIDAENS, F AMANT, H WILDIERS, P … - International Journal of Gynecological Cancer, 2006 - Blackwell Synergy
... from published/presented trials, all three AIs show great promise over tamoxifen ...
Long-term serious side effects of tamoxifen like endometrial cancer and ...

Chemoprevention of Second Cancers -
ST Mayne, B Cartmel - Cancer Epidemiology Biomarkers & Prevention, 2006 - AACR
... factor receptor?targeted agents hold promise in the ... has provided research examples
that show that chemoprevention ... lessened some of the side effects known to ...

Source: Google Scholar

Early Results Show Promise In Reducing Side Effects From Anastrozole, UK
A common osteoporosis drug can shield women against the loss of bone mineral density - a side effect of the drug anastrozole which is taken to prevent breast cancer in the IBIS-2 study - according to new data presented at the San Antonio Breast Cancer Symposium.

The data being presented are from the IBIS-2 Bone Sub Study. IBIS-2 is a breast cancer prevention trial looking to see if the drug anastrozole can prevent breast cancer in women at high risk of the disease. The bone sub study has been designed to examine the effects of anastrozole on bone mineral density and whether the extra risk of developing osteoporosis or fractures among women taking part in IBIS-2 can be reduced or even eliminated.

Early results showed that after one year on the trial those women taking a type of osteoporosis drug called bisphosphonate2 had increased bone mineral density. This increase is despite the women starting the trial with low bone mineral density and being at higher risk of osteoporosis.
Anastrozole is currently only used as a treatment for breast cancer and the only women in the UK using the drug for prevention are those taking part in the IBIS-2 trial. Anastrozole works by blocking the production of oestrogen. By reducing the levels of oestrogen in the body the researchers are hoping to stop those breast cancers that rely on oestrogen from growing. It is also this reduced level of oestrogen that can reduce bone mineral density.

Dr Shalini Singh, who leads the bone sub study and presented the data, said: "Research into the effect that anastrozole has on women's bones and to extent to which a bisphosphonate can help counter this continues. These preliminary, one year data are encouraging though and we look forward to the three year results to see if this effect is maintained."

Professor Jack Cuzick, IBIS-2 co-chairman, who is based at Cancer Research UK's centre for Epidemiology, Mathematics and Statistics, said: "Although these are still very early results, they are reassuring for women participating in the IBIS-2 trial and also for those who may be taking anastrozole as part of their treatment for breast cancer. We still need more eligible women to come forward and take part in this study, which aims to provide them and future generations with valuable information on how to help prevent and control breast cancer."

For more information on the trial, please visit the IBIS website , CancerHelp UK or call the Cancer Research UK cancer information nurses on 0808 800 4040.

Notes:

IBIS-2 (International Breast cancer Intervention Study II) is a ten year study involving 10,000 healthy women who are at an increased risk of breast cancer.

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IBIS-2 is being coordinated by Cancer Research UK and sponsored by Queen Mary, University of London. The trial is taking place in 21 countries, including Australia, India, Chile, Germany and Italy.

The IBIS-2 Prevention part of the study aims to recruit 6,000 post-menopausal women who are at increased risk of developing breast cancer. A number of factors for increased risk can make a woman eligible to enter the study and these are set according to the different age groups. Women can take part in the trial if they are aged between 40-70 years and are not on HRT.

IBIS-2 DCIS will recruit 4,000 postmenopausal women who have been diagnosed with and had surgery to remove DCIS (Ductal carcinoma in situ). This part of the trial is designed to determine which of the two drugs, anastrozole or tamoxifen, can best prevent new cancers, both in the breast affected by DCIS and in the opposite breast. Women who have had a mastectomy to remove their DCIS cannot join this arm of the trial but they can be part of the prevention part.

About Cancer Research UK

- Together with its partners and supporters, Cancer Research UK's vision is to beat cancer.
- Cancer Research UK carries out world-class research to improve understanding of the disease and find out how to prevent, diagnose and treat different kinds of cancer.
- Cancer Research UK ensures that its findings are used to improve the lives of all cancer patients.
- Cancer Research UK helps people to understand cancer, the progress that is being made and the choices each person can make.
- Cancer Research UK works in partnership with others to achieve the greatest impact in the global fight against cancer.

http://www.cancerresearchuk.org
 
 
 
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