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Recent News and Articles on the Keywords: human semen + hiv infection + ingredient  Related to the article below (Last Update: 5/5/2008)

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Source: Google News

Comparison of Microbicides for Efficacy in Protecting Mice Against Vaginal Challenge With Herpes … -
RA MAGUIRE, N BERGMAN, DM PHILLIPS - Sexually Transmitted Diseases, 2001 - stdjournal.com
... cytotoxic effect they may have on human vaginal cells ... L acidophilus, and for their
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Prophylactic contraceptives for HIV/AIDS -
FM Uckun, OJ D'Cruz - Human Reproduction Update, 1999 - ESHRE
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Clinical development of microbicides for the prevention of HIV infection. -
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Contraception: Effects of cholic acid and'Protectaid'formulations on human sperm motility and … -
AM Courtot, N Nikas, A Gravanis, A Psychoyos - Human Reproduction, 1994 - ESHRE
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… phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV … -
OJ D?Cruz, Z Zhu, SH Yiv, CL Chen, B Waurzyniak, … - Contraception, 1999 - Elsevier
... Infection by human immunodeficiency virus (HIV), the ... infected mononuclear cells in
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… of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities* -
OJ D'Cruz, MJ Shih, SH Yiv, CL Chen, FM Uckun - Molecular Human Reproduction, 1999 - Oxford Univ Press
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Cryopreservation of Human Semen -
J Brotherton - Systems Biology in Reproductive Medicine, 1990 - informaworld.com
... the USA) because of the AIDS (HIV) epidemic.? As it ... of AID with cryopreserved donor
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REVIEW HHV-8 infection: a model for reactivation and transmission -
L Corey, S Brodie, ML Huang, DM Koelle, A Wald - Rev. Med. Virol, 2002 - doi.wiley.com
... viral clades can be placed into distinct geographic regions, indicating a long
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Interleukin (IL)-1, IL-6, and IL-8 Predict Mucosal Toxicity of Vaginal Microbicidal Contraceptives -
RN Fichorova, M Bajpai, N Chandra, JG Hsiu, M … - Biology of Reproduction, 2004 - bioone.org
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Source: Google Scholar

Ingredient in human semen may enhance HIV infection

Last Updated: 2007-12-14 9:01:10 -0400 (Reuters Health)

CHICAGO - An ingredient in human semen may actually help the HIV virus infect cells, German researchers said on Thursday.

They said naturally occurring prostatic acidic phosphatase or PAP, an enzyme produced by the prostate, can form tiny fibers called amyloid fibrils that can capture bits of the human immunodeficiency virus and usher it into cells.

Researchers at the University Clinic of Ulm were looking for factors in semen that might block infection with HIV-1, the most common strain of the virus that causes AIDS.

Instead, they found one that enhanced transmission, in some experiments as much as 50-fold.

"In this study we show that fragments of PAP, a highly abundant semen marker, form amyloid fibrils that drastically enhance the infectiousness of HIV-1," they wrote in the journal Cell.

They said they are now looking for compounds that might block this process to slow transmission of the disease.

Amyloid fibrils formed from different proteins are associated with many diseases, including Alzheimer's and prion disease.

"Further studies on the role of amyloids in the transmission and pathogenesis of enveloped viruses are highly warranted," they wrote.

HIV has infected some 60 million people, killing more than 20 million, the researchers said. More than 90 percent of those infections are acquired through sexual intercourse.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 

 

 
 
 
 
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