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Recent News and Articles on the Keywords: brain cancer + study results + brain  Related to the article below (Last Update: 5/5/2008)


CTV.ca
Canadian-born doctor's vaccine fights brain cancer
CTV.ca, Canada -
DeGrand was given a year to live when doctors found a baseball-sized tumour in his brain. After the cancer was removed, he enlisted in Sampson's study. ...

Cit? Libre Magazine
Study Links Cell Phones To Brain Cancer Risk
Cit? Libre Magazine, Canada - May 3, 2008
The investigators have a much larger brain tumour study ongoing with about 1500 incident patients and 1500 controls and the results are expected within one ...
Work exposure to weed killers tied to brain cancer
Reuters India, India - May 2, 2008
A few studies, but not all, have linked both farming and heavy pesticide exposure to a higher risk of brain cancer. For the current study, published in the ...
Significant Reduction in Local Recurrence With Conventional ...
DG News -
These results suggest that "conventional surgery should be considered the gold standard for treatment of patients with single-brain metastases when either ...
Herbicide Exposure Leads to Higher Risk of Brain Cancer in Women
RedOrbit, TX - May 3, 2008
A recent study found that women who work regularly around weed killers could be at an increased risk of a certain type of brain cancer. ...
Brain Magnetic Resonance Imaging Scans for Asymptomatic Patients ...
RedOrbit, TX - May 3, 2008
The American Cancer Society states that, in most cases, the type of tumor and its location determines survival of patients with brain cancer, not how early ...
Analysis Of Alcoholics' Brains Suggests Treatment Target
Science Daily (press release) - May 2, 2008
ScienceDaily (May 2, 2008) ? An analysis of brain tissue samples from chronic alcoholics reveals changes that occur at the molecular level in alcohol abuse ...
Reuters Health News Summary
San Diego Union Tribune, United States - May 3, 2008
... whose jobs regularly expose them to weed killers may have a higher-than-normal risk of a particular form of brain cancer, results of a US study suggest. ...

TopCancerNews.com
The key to prevent Cancer's Recurrence is stress reduction
TopCancerNews.com, TX - May 3, 2008
Pre-clinical studies in a 2005 study also published in Brain, Behaviour, and Immunity reveal that by blocking these stress hormones, cancer metastases in ...
Recurrent Brain Cancer
Advance for Speech-Language Pathologists and Audiologists, PA - Apr 29, 2008
Study results substantially exceeded the pre-specified thresholds set for this work. Vascular endothelial growth factor (VEGF) has an important biologic ...
Source: Google News

Risk of Breast Cancer in Relation to Lifetime Alcohol Consumption -
MP Longnecker, PA Newcomb, R Mittendorf, ER … - jnci, 1995 - jnci.oxfordjournals.org
... W. Clapp , Gregory F. Bogdan , John Baron , Brain MacMahon , Walter C ... of the Women's
Contraceptive and Reproductive Experiences Study Cancer Epidemiol. ...

Results of a phase III study of early versus delayed whole brain radiotherapy with concurrent … -
G Robinet, P Thomas, JL Breton, H Lena, S Gouva, G … - Annals of Oncology, 2001 - pt.wkhealth.com
... Results of a phase III study of early versus ... and vinorelbine combination in inoperable
brain metastasis of non-small-cell lung cancer: Groupe Fran?ais de ...

Family pesticide use and childhood brain cancer -
JR Davis, RC Brownson, R Garcia, BJ Bentz, A … - Archives of Environmental Contamination and Toxicology, 1993 - Springer
... not significantly associated with child- hood brain cancer in our ... Agency for Research
on Cancer (1979) has ... of carbaryl are limited and study results are mixed ...

… vinorelbine in advanced non-small-cell lung cancer: final results of a multicenter phase II study. -
… Voisin, M Bekradda, JC Saltiel, E Brain, O Rixe, Y … - Annals of Oncology, 2002 - pt.wkhealth.com
... plus vinorelbine in advanced non-small-cell lung cancer: final results of a multicenter
phase II study. ... Bekradda, M. 5,6 ; Saltiel, JC 4 ; Brain, E. 3 ...

… Case-Control Study of Adult Brain, Head and Neck Tumours: Results of the Feasibility Study -
E Cardis, M Kilkenny - Radiation Protection Dosimetry, 1999 - NTP
... of Adult Brain, Head and Neck Tumours: Results of the ... that it is feasible to develop
a study of the relation between mobile telephone use and brain cancer risk ...

Handheld Cellular Telephone Use and Risk of Brain Cancer -
JE Muscat, MG Malkin, S Thompson, RE Shore, SD … - JAMA, 2000 - Am Med Assoc
... from the Surveillance, Epidemiology and End Results database and ... al 21 reported that
US brain cancer rates between ... This study and other surveys 22 found that ...

The Use of Significant Others as Proxy Raters of the Quality of Life of Patients with Brain Cancer. -
KCA Sneeuw, NK Aaronson, D Osoba, MJ Muller, MA … - Medical Care, 1997 - lww-medicalcare.com
... QLQ-C30 supplemented by a brain cancer specific module, the QLQ-BCM. For both
questionnaires, the study provided generally encouraging results regarding the ...

… medical history in brain tumour development. Results from the international adult brain tumour study -
B Schlehofer, M Blettner, S Preston-Martin, D … - International Journal of Cancer, 1999 - doi.wiley.com
... In addition, 331 menin- gioma cases from 6 study centres (27.5 ... 6.2%) matched controls
reported a history of cancer of sites other than the brain; 16 (4.8 ...

Stereotactic Radiosurgery for the Definitive, Noninvasive Treatment of Brain Metastases -
E Alexander, TM Moriarty, RB Davis, PY Wen, HA … - jnci, 1995 - jnci.oxfordjournals.org
... Whole brain radiotherapy was given to all newly diagnosed patients ... Results of this
study also indicate that radiosurgery not only provides ... [J Natl Cancer Inst 87 ...

Risk factors for tumors of the brain and meninges: results from the Adelaide Adult Brain Tumor Study … -
P Ryan, MW Lee, B North, AJ McMichael - Int J Cancer, 1992 - ncbi.nlm.nih.gov
Int J Cancer. 1992 Apr 22;51(1):20-7. Risk factors for tumors of the brain and
meninges: results from the Adelaide Adult Brain Tumor Study. ...

Source: Google Scholar

Drug Study for Brain Cancer Shows Promising Results

A clinical study conducted at Henry Ford Hospital on the use of a drug to extend the survival of patients with the most common and aggressive type of brain cancer, has yielded results that were significantly better than expected.

The randomized Phase II study focused on patients with glioblastoma multiforme (GBM), whose cancer had recurred after first- or second-line therapy. The study revealed that more than a third who were treated with Avastin (bevacizumab) alone, as well as more than half of those treated with Avastin in combination with the chemotherapy drug irinotecan, lived without further progression of the disease for a period of six months. In addition, no new or unexpected adverse effects from the use of Avastin were observed during the study.

“This is very encouraging news,” says Tom Mikkelsen, M.D., a neuro-oncologist who is the study’s principal investigator at Henry Ford and co-director of the Hermelin Brain Tumor Center. "Historical estimates suggest that only 15 percent of patients with this aggressive type of brain cancer live without their cancer progressing within six months. Although gliomas [fast-growing malignant brain tumors] are nearly always incurable, use of a drug like Avastin may help to buy precious time for patients, as well as to preserve their physical and mental functions longer than was previously possible.”

Avastin is a therapeutic antibody designed to inhibit Vascular Endothelial Growth Factor (VEGF), a protein that stimulates development of new blood vessels in a process known as angiogenesis, while maintaining existing tumor vessels. By binding to VEGF, Avastin acts as an anti-angiogenesis agent that chokes off the blood supply to tumors, which in turn inhibits their growth and metastasis.

The national study is sponsored by Genentech and Henry Ford Hospital is one of the large study sites.

“The same process that makes gliomas so deadly may turn out to be exactly the same thing that makes it possible to slow down their progression,” Dr. Mikkelsen says. "This is a very significant advance in the battle to control these aggressive tumors because it could lead to treatment options where none existed previously for patients with recurrent disease.”

Previously Avastin had been used in combination with chemotherapy as a first-line treatment for metastatic colorectal cancer and lung cancer. Because of its demonstrated success rate with these cancers, Avastin currently is being studied worldwide in more than 300 clinical trials for 20 different tumor types.

“With currently approved therapies, the chances of suppressing GBM are poor at less than 10 percent,” says Dr. Mikkelsen. “This type of targeted therapy using Avastin may prove to be the best new hope we have for helping patients with recurrent disease who previously had few options available to them.”

According to the American Cancer Society (ACS), the five-year survival
rate for patients with GBM is 3 percent, a figure that has not changed in more than 25 years. The ACS estimates there will be 20,500 new cases of brain cancer and 12,740 brain cancer deaths in 2007.
 
 
 
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