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Recent News and Articles on the Keywords: somatic evolution + evolution + explain  Related to the article below (Last Update: 5/5/2008)

It's science vs. religion again in Louisiana's Legislature
Knoxville News Sentinel, TN - Apr 26, 2008
... religious-based instruction in science classes. Backers of the bill, meanwhile, have already introduced new legislation specifically targeting evolution.
Do we want a truly liberal society?
Institute for Ethics and Emerging Technologies, CT - Apr 14, 2008
Enhancing Evolution: The Ethical Case for Making Better People. Princeton: Princeton University Press. Hart, HLA (1963). Law, Liberty, and Morality. ...
Source: Google News

Evolution of somatic hypermutation and gene conversion in adaptive immunity. -
M Diaz, MF Flajnik - Immunological Reviews, 1998 - pt.wkhealth.com
... it provides a scenario in which both somatic hypermutation and ... This model requires
the evolution of a targeting ... mechanism would be difficult to explain by this ...

Evolution of Senescence: Late Survival Sacrificed for Reproduction -
TBL Kirkwood, MR Rose - Philosophical Transactions: Biological Sciences, 1991 - JSTOR
... of increase r, and the level of investment in somatic maintenance s ... is not the case,
then there is nothing to explain about the evolution of senescence ...

Evolution of Autoantibody Responses via Somatic Hypermutation Outside of Germinal Centers -
J William, C Euler, S Christensen, MJ Shlomchik - Science, 2002 - sciencemag.org
... Inferred intermediates in clonal evolution are represented ... We therefore propose that
somatic hypermutation is ... This hypothesis would explain why mutation occurs ...

The Evolution of Ageing and Longevity -
TBL Kirkwood, R Holliday - Proceedings of the Royal Society of London. Series B, …, 1979 - JSTOR
... It would be a mistake to believe that somatic ageing is inevitably associated with ...
The first attempt to explain evolution of ageing was made by Weismann (I89I ...

[BOOK] Developmental Plasticity and Evolution
MJ West-Eberhard - 2003 - books.google.com
... Concept 81 Complementarity 83 Landmarks in the Evolution of Modularity 84 xv Page
14. xvi Chaprer Conteuts Hypermodularity and Somatic Sequestration 86 General ...

… Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic … -
M Diaz, J Velez, M Singh, J Cerny, MF Flajnik - International Immunology, 1999 - Jpn Soc Immunol
... Furthermore, the similar bias for transitions seen in somatic hypermutation and
pseudogenes in evolution cannot be explained by an active role of repair ...

Evolution of Antibody Variable Region Structure during the Immune Response -
T Manser, LJ Wysocki, MN Margolies, ML Gefter - Immunological Reviews, 1987 - Blackwell Synergy
... are selected for an increase in antigenic specificity rather than affinity per se
during the somatic evolution process. We have explained the affinity ...

Somatic polyploidization and cellular proliferation drive body size evolution in nematodes -
AJ Flemming, ZZ Shen, A Cunha, SW Emmons, AM Leroi - Proc Natl Acad Sci US A, 2000 - pubmedcentral.nih.gov
... Cell Number and Somatic Ploidy Account for Body Size Evolution in Nematodes. ... Can
haploid genome size or hypodermal ploidy explain more of the variation in ...

Evolution by individuals, plant-herbivore interactions, and mosaics of genetic variability: The …
TG Whitham, CN Slobodchikoff - Oecologia, 1981 - Springer
... Evolution by Individuals In addition to providing a source ... may have been greatly
facilitated by somatic mutations ... would still be insufficient to explain how the ...

[BOOK] Somatic Selection and Adaptive Evolution: On the Inheritance of Acquired Characters -
EJ Steele - 1981 - books.google.com
... OF THE RNA TUMOR VIRUSES TO THE SOMATIC SELECTION HYPOTHESIS 97 ... to the concept of
selective survival, help explain the phenomenon of evolution as we ...

Source: Google Scholar

Bodily breakdown explained: How cell differentiation patterns suppress somatic evolution

Natural selection can occur at the cellular level, where it is detrimental to health. Fortunately it is normally controlled by a well-known pattern of ongoing cell differentiation in the mature tissues of animals, according to a new study published December 14 in PLoS Computational Biology.

The failure of normal cell differentiation patterns may explain cancer and senescent decline with aging, say researchers at the University of Arizona, the Santa Fe Institute, the University of Pennsylvania, and the Wistar Institute.

Darwinian natural selection and evolution is usually studied in populations of organisms, but it also applies to cellular populations; this is called “somatic” evolution. Such somatic evolution tends to reduce cooperation among cells, thus threatening the integrity of the organism.

In this study the authors proposed that a well-known pattern of ongoing cell differentiation in the mature tissues of animals functions to suppress somatic evolution, which is essential to the origin and sustainability of multicellular organisms.

The team, lead by Dr. John Pepper, tested this hypothesis using a computer simulation of cell population dynamics and evolution. The results were consistent with the hypothesis, suggesting that familiar patterns of ongoing cell differentiation were crucial to the evolution of multicellular animals, and remain crucial as a bodily defense against cancer.

###

CITATION: Pepper JW, Sprouffske K, Maley CC (2007) Animal cell differentiation patterns suppress somatic evolution. PLoS Comput Biol 3(12): e250. doi:10.1371/journal.pcbi.0030250

CONTACT:

Dr. John Pepper
University of Arizona
520-250-2438
jpepper1@email.arizona.edu

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