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Recent News and Articles on the Keywords: stem-cell patch + stem cell + heart  Related to the article below (Last Update: 5/5/2008)

Scientists Derive Cardiac Stem Cell; Study May Strengthen VistaGen ...
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Source: Google News

Stem Cell-Derived Cardiomyocytes Demonstrate Arrhythmic Potential -
YM Zhang, C Hartzell, M Narlow, SC Dudley - Circulation, 2002 - Am Heart Assoc
... 9?11 The perforated patch results suggested ... arrhythmia mechanisms, and stem cell
engraftment preferentially in ... mice from early-passage embryonic stem cells. ...

Autologous stem cell transplantation for myocardial repair -
J Liu*, Q Hu, Z Wang, C Xu, X Wang, G Gong, A … - … Journal of Physiology- Heart and Circulatory Physiology, 2004 - Am Physiological Soc
... B): X-gal staining shows that "blue" cells are homing ... bp products were found only
in patch and periscar ... D: in stem cell culture medium, the blue cells migrated ...

Retinoic Acid Accelerates Embryonic Stem Cell-Derived Cardiac Differentiation and Enhances … -
AM Wobus, G Kaomei, J Shan, MC Wellner, J Rohwedel … - Journal of Molecular and Cellular Cardiology, 1997 - Elsevier
... WM F????. Retinoic Acid Accelerates Embryonic Stem Cell-derived Cardiac ... was also
found by patch-clamp analysis ... that treatment of embryonic stem (ES) cell ...

Stable benefit of embryonic stem cell therapy in myocardial infarction -
DM Hodgson, A Behfar, LV Zingman, GC Kane, C Perez … - … Journal of Physiology- Heart and Circulatory Physiology, 2004 - Am Physiological Soc
... a highly enriched population of stem cell-derived cardiomyocytes as ... Zeiss) using
anti-MEF2C (Cell Signaling Technology ... was determined by patch-clamp recording ...

Stem Cell Repair of Infarcted Myocardium: An Overview for Clinicians -
JS Forrester, MJ Price, RR Makkar - Circulation, 2003 - Am Heart Assoc
... trials (Table 2). First, the size of the murine heart and its ... Stem cell?derived
cardiomyocytes studied in vitro using whole-cell patch clamps show ...

… Ventricular Remodeling by Front-Integrated Revascularization and Stem Cell Liberation in Evolving … -
H Ince, M Petzsch, HD Kleine, H Schmidt, T Rehders … - Circulation, 2005 - Am Heart Assoc
... in target tissue but for colonization of metabolically active cells. Although stem
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Stem cell therapy for myocardial repair Is it arrhythmogenic?* -
RR Makkar, M Lill, PS Chen - Journal of the American College of Cardiology, 2003 - Am Coll Cardio Found
... cells was less than that of intact human heart. ... in vitro using the whole-cell
patch-clamp method ... Cultured stem cell-derived cardiomyocytes exhibited morphologic ...

Differentiation of Human Embryonic Stem Cells to Cardiomyocytes -
C Mummery, D Ward-van Oostwaard, P Doevendans, R … - Circulation, 2003 - Am Heart Assoc
... Electrophysiology Patch-clamp electrophysiology on dissociated hES ... Embryonic stem
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Pluripotent mouse embryonic stem cells are able to differentiate into cardiomyocytes expressing … -
AM Wobus, G Wallukat, J Hescheler - Differentiation, 1991 - Blackwell Synergy
... The embryonic stem cell lines D3 [8] and B117 were ... In the cell attached patch
configuration [ 151, the ... BL17 cultivated on feeder layer as undirrcrcntiated stem ...

Decreased neural crest stem cell expansion is responsible for the conotruncal heart defects within … -
SJ Conway, J Bundy, J Chen, E Dickman, R Rogers, … - Cardiovascular Research, 2000 - cardiovascres.oxfordjournals.org
... fail to undergo normal NC stem cell proliferative expansion ... 5,10] and Sp alleles
[11]; Patch [12] and ... heart, pre-migratory cardiac NC stem cells are initially ...

Source: Google Scholar

Stem-cell patch may fix damaged hearts

Last Updated: 2007-12-13 10:00:52 -0400 (Reuters Health)

By Ben Hirschler

LONDON - Scientists have made two significant advances in developing a stem-cell patch to repair the damage caused to the heart after an attack.

Sian Harding of London's Imperial College said on Thursday her team had successfully matured beating heart cells in a laboratory dish for up to seven months and developed a biocompatible scaffold to form the basis of a patch.

The idea is to stitch or glue a patch of new tissue derived from embryonic stem cells over the damaged area of the heart to make the muscle viable again.

During a heart attack, or myocardial infarct, part of the heart muscle loses its blood supply and the oxygen-starved cells die, causing scarring.

"We really would like to cover the area of the infarct scar as much as possible, so it might be quite a large patch," Harding said in an interview.

"We think the patch itself will stop the scar expanding, which is one of the big problems when you have a myocardial infarction because the scar becomes weak and can bulge out."

The biomaterial developed for the patch is designed to have the same elasticity as heart muscle and can also be programmed to degrade safely in anything from two weeks upwards.

Several groups around the world are working on different ways to use stem cells in heart repair but a key challenge is to get cells to function properly.

By showing stem cell-derived heart cells can beat in a coordinated fashion for months on end, the Imperial team believes their patch should function smoothly alongside normal heart muscle, without causing abnormal heart rhythms.

Harding, who will present her research at a UK Stem Cell Initiative conference, said initial human trials of the patch could be underway within five years -- after safety studies on animals and tests to see if the new cells are rejected.

Stem cells are controversial but the field received a boost last month when researchers reported they had turned ordinary human skin cells into batches of cells that looked and acted like embryonic stem cells, without using human eggs or embryos.

"That is a very promising development," Harding said. "They have made heart muscles from those cells and this technique has the potential both for getting round the ethical problems and for producing patient-specific cells."

Making stem cells from a patient's own tissue would avoid the problems of transplant rejection.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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