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Recent News and Articles on the Keywords: early treatment + epilepsy treatment + epilepsy  Related to the article below (Last Update: 7/9/2008)


CTV.ca
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I've faced death twice so every day is precious
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It is the UK's first genetic testing service to identify complex forms of childhood epilepsy and help with early identification of genetic epilepsy. ...

MedPage Today
Electromagnetic Treatments for Depression Seek to Improve on ECT
MedPage Today, NJ - Jul 4, 2008
The idea came from its earlier, successful use in treating epilepsy. Clinicians noticed mood improvements following the device's activation, ...
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In addition to the CNS area of research, SK Life Science is working on the discovery and development of novel therapeutic compounds for the treatment of ...TSE:PTI - SEO:003600
UPDATE 1-Sepracor epilepsy drug cuts seizures in studies
Reuters - Jun 19, 2008
O: Quote, Profile, Research) said on Thursday late-stage studies of its experimental epilepsy treatment showed a significant reduction in partial seizures ...
Sepracor Announces Phase III Data for Eslicarbazepine Acetate ... Business Wire (press release)
Sepracor announces results of Phase III trials of epilepsy drug ... RTT News
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RTT News
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Letsigner takes on rare genetic disease just like diving
GoVolsXtra, TN - Jul 5, 2008
"I went to the doctor to make sure I wasn't epileptic because UT didn't want me to seizure out in the middle of a dive," Letsinger said. ...
Zebinix a New Anti-epileptic Drug That Offers Hope to Epilepsy ...
PharmaLive.com (press release), PA - Jun 20, 2008
About partial seizures and their treatment Epilepsy is one of the most common neurological diseases, affecting almost 1 in 100 people. Treatment of partial ...
Full Text
Science Magazine (subscription) - Jul 3, 2008
Until the early 20th century, many people with epilepsy lived in asylums or other institutions, where staff recognized that patients sometimes died during ...
Fighting to find a cure
Journal Live, UK - Jul 7, 2008
The youngster takes two tablets daily to control her epilepsy and sees specialists at Newcastle General Hospital and the Centre For Life. ...
Source: Google News

Early Identification of Refractory Epilepsy -
P Kwan, MJ Brodie - New England Journal of Medicine, 2000 - content.nejm.org
... {blacktriangledown}Tiagabine: add-on treatment for partial seizures. DTB 38:
47-48 [Abstract] [Full Text]; (2000). Refractory Epilepsy Declares Itself Early. ...

[CITATION] Early Treatment and Prognosis of Epilepsy -
EH Reynolds - Epilepsia, 1987 - Blackwell Synergy
... Early Treatment and Prognosis of Epilepsy EH Reynolds ... Early effective treatment may
also be important in preventing the evolution of chronic epilepsy. ...

Treatment of first tonic-clonic seizure does not improve the prognosis of epilepsy. First Seizure … -
M Musicco - Neurology, 1997 - AAN Enterprises
... RJ Davenport, and AJ Gray Early management of ... JW Sander The natural history of epilepsy:
an epidemiological ... and S. Shinnar Practice parameter: Treatment of the ...

Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a … -
A Marson, A Jacoby, A Johnson, L Kim, C Gamble, D … - The Lancet, 2005 - Elsevier
... 4 EH Reynolds, Early treatment and prognosis of epilepsy, Epilepsia 28
(1987), pp. 97?106. Full Text via CrossRef | View Record ...

[CITATION] Depression in Epilepsy: Etiology, Phenomenology, and Treatment -
MV Lambert, MM Robertson - Epilepsia, 1999 - Blackwell Synergy
... Seizures tend to occur early in treatment or after dose ... Key Words: Depression-Epilepsy-
Antiepileptic drugs- Selective serotonin reuptake inhibitors. ...

Do anticonvulsants alter the natural course of epilepsy? Treatment should be started as early as …
EH Reynolds - BMJ, 1995 - ncbi.nlm.nih.gov
BMJ. 1995 Jan 21;310(6973):176-7. Click here to read Do anticonvulsants alter the
natural course of epilepsy? Treatment should be started as early as possible. ...

[CITATION] Surgical Treatment of Children with Medically Intractable Frontal or Temporal Lobe Epilepsy: Results … -
DR Fish, SJ Smith, LF Quesney, F Andermann, T … - Epilepsia, 1993 - Blackwell Synergy
... Surgical treatment of epilepsy during childhood ... Jayakar P, Resnick TJ, Duchowny MS,
Alvarez LA, Levin BE, Morrison G. Outcome of very early frontal lobectomy ...

Juvenile myoclonic epilepsy of Janz -
AV Delgado-Escueta - Neurology, 1984 - AAN Enterprises
... M. Sato Neuropsychological EEG activation in patients with epilepsy Brain, February
1 ... D. Chadwick Controversies in Management: Case for early treatment is not ...

[CITATION] Antiepileptic Drug Treatment of Benign Childhood Epilepsy with Rolandic Spikes: Is It Necessary? -
G Ambrosetto, CA Tassinari - Epilepsia, 1990 - Blackwell Synergy
... AED treatment differ, to some extent, from those of epilepsies other than BERS.
Gener- ally, prognostic studies of epilepsy attempt to search for early risk ...

Oxcarbazepine in the treatment of early childhood epilepsy. -
E Gaily, ML Granstrom, E Liukkonen - J Child Neurol, 1997 - ncbi.nlm.nih.gov
J Child Neurol. 1997 Nov;12(8):496-8. Oxcarbazepine in the treatment of
early childhood epilepsy. Gaily E, Granstrom ML, Liukkonen ...

Source: Google Scholar

Early treatment stops epilepsy in its tracks

New Haven, Conn.—Yale School of Medicine researchers have shown for the first time that it is possible to suppress the development of epilepsy in genetically predisposed animals—which could open the door to treating epilepsy as a preventable disease.

According to the study published this month in Epilepsia, early treatment of epilepsy-prone rats with the anti-convulsant medication ethosuximide before the onset of seizures led to a marked suppression of seizures both later in life and months after treatment stopped.

“Current treatments for epilepsy may control seizures, but they do nothing to alter the underlying disease,” said Hal Blumenfeld, M.D., associate professor of neurology and lead author of the study. “These findings are important because they set the stage for prevention of epilepsy in genetically susceptible people.”

Epilepsy is a common neurological disorder that affects about 50 million people worldwide. It is characterized by seizures—temporary loss of consciousness or muscular control—that are precipitated by abnormal electrical overload on neurons within the brain.

Using a combination of molecular profiling, electroencephalogram (EEG) recordings, and power spectral analysis, Blumenfeld and his colleagues demonstrated that ethosuximide effectively blocked the expression of an epilepsy-associated maladaptive protein within neurons of the brain and reduced the number of seizures in treated animals.

“These findings prove that prevention of epilepsy in people is an achievable goal,” Blumenfeld said. “Strategies for primary prevention of diseases like epilepsy will be increasingly important as genetic prediction of these diseases improves.”

He said the results must be confirmed in other animals and with other medications before moving on to human treatment trials.

###

Epilepsia (doi:10.1111/j.1528-1167.2007.01458.x) (7 Dec 2007)

 
 
 
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