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Recent News and Articles on the Keywords: mature t-cells + embryonic stem + stem  Related to the article below (Last Update: 5/5/2008)

Mature B Cells Reprogrammed To Stem-cell-like State
Science Daily (press release) - Apr 17, 2008
ScienceDaily (Apr. 17, 2008) ? Fully mature, differentiated B cells can be reprogrammed to an embryonic-stem-cell-like state, without the use of an egg ...
Source: Google News

… -based system to functionally silence genes in primary mammalian cells, stem cells and transgenic … -
DA Rubinson, CP Dillon, AV Kwiatkowski, C Sievers, … - Nature Genetics, 2003 - mousegeneticslab.org
... transgenic animals through infection of embryonic stem (ES) cells ... of these cells
to the mature spleen cells ... Functional gene silencing in T cells derived from ...

… cell development and establishment of T cell competence from embryonic stem cells differentiated in … -
TM Schmitt, RF de Pooter, MA Gronski, SK Cho, PS … - Nature Immunology, 2004 - mcb.berkeley.edu
... Embryonic stem cells (ESCs) have the potential to serve as a ... of ESC differentiation
into mature functional T ... differentiation of ESCs into T cells required the ...

… development of murine T cells from prethymic and preliver embryonic yolk sac hematopoietic stem -
CP Liu - Development, 1991 - dev.biologists.org
... Mature T cells are derived from prethymic stem cells, which arise at one or more ...
Although the bone marrow of adult mice can provide such stem cells, their ...

Xenotransplant cardiac chimera: immune tolerance of adult stem cells -
T Saito, JQ Kuang, B Bittira, A Al-Khaldi, RCJ … - The Annals of Thoracic Surgery, 2002 - Soc Thorac Surgeons
... suppress the function of mature T cells, either directly or by stimulating suppressor
T cells, and thus ... therapeutic cloning to obtain embryonic stem cells, a ...

The immunogenicity of human embryonic stem-derived cells -
M Drukker, N Benvenisty - Trends in Biotechnology, 2004 - Elsevier
... In addition, hematopoietic progenitors derived from embryonic stem cells should
not contain mature T cells so that graft versus host disease (GVHD) will not ...

In vitro differentiation of embryonic stem cells -
GM Keller - Current Opinion in Cell Biology, 1995 - Elsevier
... First, the generation of mature lineages from ES cells in ... are unable to generate
any B or T cells, are easier ... endothelial cells and cells of the embryonic brain ...

Isolation of a candidate human hematopoietic stem-cell population. -
CM Baum, IL Weissman, AS Tsukamoto, AM Buckle, B … - Proceedings of the National Academy of Sciences of the …, 1992 - pubmedcentral.nih.gov
... of individual human hematopoietic stem cells cultured ... Walker E. Characterization
of adult human marrow ... Mature T cells generated from single thymic clones are ...

Directed differentiation of dendritic cells from mouse embryonic stem cells -
PJ Fairchild, FA Brook, RL Gardner, L Gra?a, V … - Current Biology, 2000 - Elsevier
... greatly enhanced responses among allogeneic T cells ( Fig ... a). Syngeneic responses
elicited by mature esDCs (open ... Fung-Leung and TW Mak, Embryonic stem cells and ...

Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities -
IL Weissman - Science, 2000 - sciencemag.org
... into immunodeficient newborn mice or immunosuppressed adult rats and ... for development
of autoimmune T cells can map ... wherein the generation of mature or maturing ...

… of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of … -
DC Colter, I Sekiya, DJ Prockop - Proceedings of the National Academy of Sciences, 2001 - National Acad Sciences
... small and granular RS cells; mMSC, mature MSC ... of type II collagen-reactive T cells
in rheumatoid ... and EG Loboa Human adipose-derived adult stem cells upregulate ...

Source: Google Scholar

Mature T-cells have been developed for the first time from human embryonic stem cells, and the U.S. researchers involved hope a new AIDS therapy will follow.

T-cells are key components in the immune system and lead the body's fight against infection. The AIDS virus destroys T-cells, and people with AIDS typically die from unusual infections people with healthy immune systems do not get, such as pneumocystis pneumonia.

The work was done at the UCLA AIDS Institute and the Institute for Stem Cell Biology and Medicine, where scientists led by Zoran Galic and Jerome Zack incubated human embryonic stem cells on mouse bone marrow support cells.

The researchers explained that stem cells are blank slates that decide how they will mature based on the biological environment in which they find themselves. The mouse bone marrow encouraged the human stem cells to develop into blood-forming (hematopoietic) cells. The new hematopoietic cells were then injected into a human thymus gland implanted in a mouse, and the thymus gland (where T-cells develop) changed them into T-cells.

The team hopes their process will lead to new therapies for AIDS and other T-cell diseases, such as severe combined immunodeficiency syndrome or "bubble boy disease." The study is online at http://www.pnas.org/papbyrecent.shtml.

NHLBI Offers Updated Guide with Practical Information for Lowering High Blood Pressure Through Diet

If you’re one of the 65 million American adults, one in three, with high blood pressure, you have probably heard the advice, “watch your diet, cut back on salt.” But how? Figuring out what to eat and how much to eat is not always simple.

The National Heart, Lung, and Blood Institute (NHLBI) has developed “Your Guide to Lowering Your Blood Pressure with DASH” to provide step-by-step advice on lowering and controlling high blood pressure by following the DASH eating plan. DASH, which stands for Dietary Approaches to Stop Hypertension, follows heart-healthy guidelines to limit salt or sodium, saturated fat, trans fat, and cholesterol, and focuses on increasing intake of fruits, vegetables, and fat-free or low-fat milk products. It is also rich in whole grain products, fish, poultry, and nuts.

“NHLBI studies have shown that the DASH eating plan can significantly lower high blood pressure, even within the first few weeks,” said NHLBI Director Elizabeth G. Nabel, M.D. “They demonstrate that by making healthy choices in diet and physical activity, you can get on track to a healthier life.”

The new guide updates previous publications of the DASH Eating Plan with a new look, and is consistent with the 2005 U.S. Dietary Guidelines for Americans. It also contains new information on potassium, weight loss, physical activity, a week’s worth of menus, easy-to-prepare recipes, and a food diary for recording what you eat and the physical activity you do. In addition, the guide provides tips for heart-healthy choices at every meal, even when dining out, and for increasing physical activity.

Sometimes getting started on a heart-healthy eating plan can be the hardest part. The guide provides practical advice and suggestions for beginning with small changes such as:

  • If you eat only one or two servings of vegetables per day, try adding one serving at lunch and another at dinner.

  • Gradually switch to fat-free or low-fat milk and reduce servings of soda or other sweetened beverages.

  • Choose whole grain foods, such as whole wheat bread or whole grain cereals to get added nutrients, such as minerals and fiber.

  • When shopping, read the Nutrition Facts label on foods to find sodium content, and choose items lowest in salt or sodium.

  • Start with a simple 15-minute walk during your favorite time of day and slowly build up.

  • Don’t worry about a slip. Start again, and be sure to celebrate successes.

The DASH guide is available for ordering through the NHLBI Information Center, (301) 301-592-8573 or 240-629-3255 (TTY) or online at http://hp2010.nhlbihin.net/yourguide/.

DASH is used as an example of a healthy eating plan by the U.S. Dietary Guidelines for Americans, 2005. DASH is also featured in a consumer book, A Healthier You: Based on the Dietary Guidelines for Americans, published by the U.S. Department of Health and Human Services.

Information is available on the Web at:

Your Guide to Lowering High Blood Pressure With DASH: http://www.nhlbi.nih.gov/health/public/heart/hbp/dash/index.htm

Dietary Guidelines for Americans 2005 and A Healthier You: www.healthierus.gov/dietaryguidelines/

Part of the National Institutes of Health, the National Heart, Lung, and Blood Institute (NHLBI) plans, conducts, and supports research related to the causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, and blood diseases; and sleep disorders. The Institute also administers national health education campaigns on women and heart disease, healthy weight for children, and other topics. NHLBI press releases and other materials are available online at: www.nhlbi.nih.gov.

The National Institutes of Health (NIH) — The Nation's Medical Research Agency — includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

 
 
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