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Recent News and Articles on the Keywords: active compounds + prostate cancer + potential  Related to the article below (Last Update: 5/13/2008)

Experts step up debate over health risks of some plastics What's next?
Nashua Telegraph, NH - May 10, 2008
"Scientific studies on lab animals," Schade says, "show that BPA might have adverse health impacts ranging from breast and prostate cancer, thyroid disease, ...
Halozyme Therapeutics Inc. Q1 2008 Earnings Call Transcript
Seeking Alpha, NY - May 9, 2008
The IV administered products Reclast and Boniva, currently marketed by Novartis and Roche respectively, are attractive compounds to explore for converting ...HALO
New Preclinical Data Show Significant Anti-Tumor Activity ...
FOXBusiness - Apr 13, 2008
In addition, recent evidence also points to an important potential role for the Hedgehog pathway in cancer stem cells. Cancer stem cells are progenitor ...INFI

Business Wire (press release)
Hollis-Eden Pharmaceuticals Presents Positive Data with APOPTONE ...
Business Wire (press release), CA - Apr 14, 2008
The Company also announced it has received regulatory clearance to commence a Phase I/II dose ranging clinical trial with APOPTONE in prostate cancer ...HEPH
EGFR protects cancer cells from starvation via a kinase ...
EurekAlert (press release), DC - May 5, 2008
This work was supported in part by SPORE in Prostate Cancer CA-90270, SPORE in Breast Cancer CA-116199 and Cancer Center Support Core grant CA-16672, ...
Molecular Insight Pharmaceuticals, Inc. Initiates Phase 2a Azedra ...
Business Wire (press release), CA - May 1, 2008
?Neuroblastoma is an aggressive and difficult to treat form of neuroendocrine cancer that usually affects children under five years of age,? said Katherine ...MIPI
A Plan for Living a Long and Healthy Life (Part 2)
Natural News.com, AZ - May 6, 2008
Garlic, long recognized as a natural broad spectrum antibiotic, is also a potent and proven natural cancer preventative and it is the natural enemy of ...
Preclinical data presented for
Ad-Hoc-News (Pressemitteilung), Germany - Apr 14, 2008
Further key projects in clinical development comprise thethree orally administered compounds TASQ for prostate cancer, 57-57for SLE and RhuDex? for RA. ...STO:ACTI
Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment ...
RedOrbit, TX - May 3, 2008
Smith R, von Eschenbach A, Wender R, et al, ACS Prostate Cancer Advisory Committee, ACS Colorectal Cancer Advisory Committee, ACS Endometrial Cancer ...
EST Analysis of Hop Glandular Trichomes Identifies an O ...
RedOrbit, TX - May 2, 2008
Recent studies demonstrate that xanthohumol inhibits proliferation of fibrosarcoma cells (Goto et al., 2005) and induces apoptosis in prostate cancer cells ...
Source: Google News

[PDF] … . Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer … -
H Ohtsu, Z Xiao, J Ishida, M Nagai, HK Wang, H … - J Med Chem, 2002 - urmc.rochester.edu
... a hydroxyl group are significantly less active. ... assay conditions using human prostate
cancer cell lines ... Compounds 4 showed promising antiandrogen activities in ...
-

Histone deacetylases and cancer: causes and therapies -
PA Marks, RA Rifkind, VM Richon, R Breslow, T … - Nature Reviews Cancer, 2001 - nature.com
... TSA and cyclic tetrapeptides are active at nanomolar ... acid-based hybrid polar compounds ?
azelaic bishydroxamic ... and H4 increased in the prostate tumour cells ...

Progress in Cancer Chemoprevention: Development of Diet-Derived Chemopreventive Agents 1 -
GJ Kelloff, JA Crowell, VE Steele, RA Lubet, WA … - Journal of Nutrition, 2000 - Am Soc Nutrition
... cancer targets including breast, prostate, colon and ... such agents, the National Cancer
Institute (NCI ... The active compounds provide mechanistic and pharmacologic ...

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening -
IJ Enyedy, Y Ling, K Nacro, Y Tomita, X Wu, Y Cao, … - J Med Chem, 2001 - pubs.acs.org
... of breast cancer, 30-60% of prostate cancer, 80% of B ... been employed to search the
National Cancer Institute 3D ... activity of these seven active compounds has been ...

… -2, Player or Spectator in Cyclooxygenase-2 Inhibitor-Induced Apoptosis in Prostate Cancer Cells -
X Song, HP Lin, AJ Johnson, PH Tseng, YT Yang, SK … - jnci, 2002 - jnci.oxfordjournals.org
... mechanism by which these active compounds mediate apoptosis ... and the parental compound
celecoxib induce ... the prevention and treatment of human prostate cancer. ...

… and in vivo active inhibitors of P450 17 as potential therapeutics for treatment of prostate cancer -
BG Wachall, M Hector, Y Zhuang, RW Hartmann - Bioorganic & Medicinal Chemistry, 1999 - Elsevier
... shown benefit in the treatment of prostate cancer in men ... P450 arom of the most active,
para substituted ... the other hand the meta substituted compounds might be a ...

Herbal Composition PC-SPES for Management of Prostate Cancer: Identification of Active Principles -
M Sovak, AL Seligson, M Konas, M Hajduch, M … - jnci, 2002 - jnci.oxfordjournals.org
... the in situ synthesis of these compounds has not ... predominantly of the biologically
active trans isomer ... be investigated for the management of prostate cancer. ...

Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450 -
P Hodek, P Trefil, M Stiborov? - Chemico-Biological Interactions, 2002 - Elsevier
... found to bind to the active site of ... of estrogen-dependent breast and prostate cancer,
and the ... and hepatic metabolism of flavonoid compounds between species [9 ...

Phytoestrogens: epidemiology and a possible role in cancer protection. -
H Adlercreutz - Environmental Health Perspectives, 1995 - pubmedcentral.nih.gov
... ethanolized bourbon are biologically active: a preliminary ... and other utero-vaginotrophic
compounds of low ... of demographics, diet, and prostate cancer among men ...

… compounds inhibit I kappa B kinase (IKK) and nuclear factor-kappa B (NF-kappa B) in prostate cancer …
AV Gasparian, YJ Yao, J Lu, AY Yemelyanov, LA … - Mol Cancer Ther, 2002 - ncbi.nlm.nih.gov
... NF-kappa B activity in prostate cancer cells. ... and a novel synthetic compound,
methylseleninic acid ... as a precursor of the putative active monomethyl metabolite ...

Source: Google Scholar

Active Compounds in Fungus - Potential Prostate Cancer Treatment

A new development in the fight against cancer: Recent research at the University of Haifa found that molecules found in common fungus Ganoderma lucidum aid in suppressing some of the mechanisms involved in the progression of prostate cancer. The main action of the fungus: disrupting androgen receptor activity and impeding the proliferation of cancerous cells.

Over the past 3-4 decades much scientific research has dealt with the medicinal properties of different fungi. One of the important characteristics of fungi is the ability to fight cancer in a number of ways; however most of the research has been concentrated on how fungi affect the immune system. In this research, conducted by Dr. Ben-Zion Zaidman, under the direction of Prof. Eviatar Nevo and Prof. Solomon Wasser from the Institute of Evolution at the University of Haifa, and Dr. Jamal Mahajna from the Migal Galilee Technology Center, the researchers examined how fungi fight cancer from within cells. "Up to now, research has been based on enhancing the immune system with high-molecular-weight polysaccharides that act through specific receptors in cell membranes. We concentrated our research on low-molecular-weight secondary metabolites that can penetrate the cells and act at the molecular level from within the cell itself," explained Dr. Zaidman.

 

According to Dr. Zaidman, prostate cancer, one of the most common cancers found among men in the Western World, is controlled by the androgen receptor, especially at the initial stages of development of the disease. Therefore, all of the current medications used to treat prostate cancer work to reduce the production of androgens or to interfere with their function via the androgen receptor.

At the first stage of the research, 201 organic extracts from 68 types of fungi were produced with solvents such as ether, ethyl acetate and ethanol. These solvents are used to select molecules that are small enough to act from within the cells. Of the 201 extracts, 11 were found to deter androgen receptor activity by more than 40%. In further testing, 169 extracts were tested for cancer cell growth inhibition. In this study, 14 extracts were found to be active in inhibiting prostate cancer cells.

From among the active extracts, those from Ganoderma lucidum were found to be the most effective in inhibiting the function of the androgen receptor and controlling vital development of cancerous cells. "The results of this research are particularly interesting from a commercial aspect. Potential possibilities exist to establish research and development of bioactive metabolites from Ganoderma lucidum that could yield an anti-prostate cancer drug," remarked Dr. Zaidman.
 
 
 
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