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Recent News and Articles on the Keywords: fungus compounds + ganoderma lucidum + found  Related to the article below (Last Update: 5/5/2008)

'Silent' Fungus Metabolism Awakened For New Natural Products
Science Daily (press release) - Apr 30, 2008
The explanation is thought to be that when fungi do not need certain compounds, they inhibit the transcription of the DNA that codes for the proteins that ...
Fungus threatens state's frogs, salamanders
Seattle Times, United States - May 2, 2008
Humans could be affected, too, losing out on the pharmacopeia of compounds in frog skin that has already yielded promising treatments for pain and diabetes. ...
Unhygienic poultry feed, poor waste disposal risk to human health
Daily Times, Pakistan -
He said that unbalanced feed composition was responsible for the presence of fungus, salmonella and e-coli in birds consumed in the country. ...
Do You Really Need a Green Lawn?
Hawaii Reporter, HI -
However, what amazes us is the fact that most folks in our area have lawns and replace them with new lawns when the old lawn turns brown or get fungus, etc. ...
Albert Hofmann, the Father of LSD, Dies at 102
New York Times, United States - Apr 29, 2008
... by a program there that sought to synthesize pharmacological compounds from medicinally important plants. It was during his work on the ergot fungus, ...
Sustainability is Fertilizer
Twin County News, VA -
These creatures along with nature?s earthworms, sow bugs, ants, bacteria and microbes of fungus to break down the steaming pile into natural fertilizer. ...
COA develops bactericide made of plant extracts
Taipei Times, Taiwan - Apr 18, 2008
The organic bactericides are effective in combating more than 10 types of fungus and bacteria, such as rice blast fungus, bacillus cereus and colon bacillus ...

Environment News Service
Self-cleaning Paint Uses Light to Cleanse Walls
Environment News Service - Apr 28, 2008
... exhaust and industrial smog, volatile organic compounds found in building materials and furniture, as well as organic growth such as fungus and mildew. ...
Hofmann joins Lucy in the sky with diamonds
Brisbane Times, Australia - Apr 30, 2008
... the chemistry of ergot, a fungus that grows on rye, barley and certain other plants. Looking for medically useful compounds, Hofmann synthesised LSD-25, ...
Keeping us up to date on fish kills
Richmond Times Dispatch, VA - May 3, 2008
Those fish had a fungus. Q: The task force has done a lot of work since it was formed in 2005. What's the latest on a possible cause of the kills? ...
Source: Google News

Biologically active compounds from Aphyllophorales (polypore) fungi. -
JK Zjawiony - Journal of Natural Products, 2004 - pubs.acs.org
... Finally, numerous compounds with cardiovascular, phytotoxic, immunomodulatory ... fact
many of the fungi mentioned in ... polypores such as Ganoderma lucidum (Reishi or ...

[PDF] Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum -
X Liu, JP Yuan, CK Chung, XJ Chen - Cancer Lett, 2002 - bioguru.cn
... oxygenated triterpenoid isolated from the fungus [22], was a ... a rich source of
neuroactive compounds that could ... scaven- ging activities of Ganoderma might have ...

Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell -
H Hu, NS Ahn, X Yang, YS Lee, KS Kang - International Journal of Cancer, 2002 - doi.wiley.com
... contain different chemopreventive chemotherapeutic compounds with more ... lucidum, an
oriental fungus, has been ... alcohol extract of Ganoderma lucidum can induce ...

Novel Cytotoxic Principles of Formosan Ganoderma lucidum -
CN Lin, WP Tome, SJ Won - Journal of Natural Products, 1991 - pubs.acs.org
... for the bioactive principles of Formosan Ganoderma lucidurn (Fr ... and deriva- tives
from this fungus, grown on ... 'For significant activity of the pure compound. ...

Two New Triterpenes of the Fungus Ganoderma lucidum -
MS Shiao, LJ Lin, SF Yeh, CS Chou - Journal of Natural Products, 1987 - pubs.acs.org
... TWO NEW TRITERPENES OF THE FUNGUS GANODERMA LUCZDUM ... have now been isolated from this
fungus, and many ... group because many of the interfering compounds could be ...

A Mushroom Fruiting Body-Inducing Substance Inhibits Activities of Replicative DNA Polymerases -
Y Mizushina, L Hanashima, T Yamaguchi, M Takemura, … - Biochemical and Biophysical Research Communications, 1998 - Elsevier
... extract from a basidiomycete, Ganoderma lucidum, z is unknown. ... compounds were
identified as cerebrosides, (4E,8E)-N- ... Subsequently, several fungi ...

Three New Lanostanoids from Ganoderma lucidum -
M Arisawa, A Fujita, M Saga, H Fukumura, T Hayashi … - Journal of Natural Products, 1986 - pubs.acs.org
... A Chinese drug ?Ganoderma? is the dried fruiting body ... 3), the latter isolated as
a triacetate (3a) from the fresh fruiting body of the fungus G. ... Compounds ...

[PDF] Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. -
JH Jiang, V Slivova, T Valachovicova, K Harvey, D … - International Journal of Oncology, 2004 - 147.52.72.117
... Ganoderma lucidum (Reishi), a basidiomycetous fungus, is widely used in China and
other Asian ... Alternatively, specific compounds of Ganoderma lucidum can be ...
-

… , new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, ganoderma lucidum -
Y Mizushina, N Takahashi, L Hanashima, H Koshino, … - Bioorganic & Medicinal Chemistry, 1999 - Elsevier
... 3 from the fruiting body of a basidiomycete, Ganoderma lucidum. ... as a structurally
new compound, lucidenic lactone ... 28] isolated from fungi, Fusarium moniliforme ...

Ganoderma Lucidum (Reishi) in Cancer Treatment -
D Sliva - Integrative Cancer Therapies, 2003 - ict.sagepub.com
... (Ganodermata- ceae), basidiomycetous fungi, has been ... Dif- ferent compounds with various
biological activities ... bodies or spores of Ganoderma lucidum, and some ...

Source: Google Scholar

Active compounds found in Ganoderma lucidum fungus with potential to treat prostate cancer

A new development in the fight against cancer: Recent research at the University of Haifa found that molecules found in common fungus Ganoderma lucidum aid in suppressing some of the mechanisms involved in the progression of prostate cancer. The main action of the fungus: disrupting androgen receptor activity and impeding the proliferation of cancerous cells.

Over the past 3-4 decades much scientific research has dealt with the medicinal properties of different fungi. One of the important characteristics of fungi is the ability to fight cancer in a number of ways; however most of the research has been concentrated on how fungi affect the immune system. In this research, conducted by Dr. Ben-Zion Zaidman, under the direction of Prof. Eviatar Nevo and Prof. Solomon Wasser from the Institute of Evolution at the University of Haifa, and Dr. Jamal Mahajna from the Migal Galilee Technology Center, the researchers examined how fungi fight cancer from within cells. "Up to now, research has been based on enhancing the immune system with high-molecular-weight polysaccharides that act through specific receptors in cell membranes. We concentrated our research on low-molecular-weight secondary metabolites that can penetrate the cells and act at the molecular level from within the cell itself," explained Dr. Zaidman.

According to Dr. Zaidman, prostate cancer, one of the most common cancers found among men in the Western World, is controlled by the androgen receptor, especially at the initial stages of development of the disease. Therefore, all of the current medications used to treat prostate cancer work to reduce the production of androgens or to interfere with their function via the androgen receptor.

At the first stage of the research, 201 organic extracts from 68 types of fungi were produced with solvents such as ether, ethyl acetate and ethanol.

These solvents are used to select molecules that are small enough to act from within the cells. Of the 201 extracts, 11 were found to deter androgen receptor activity by more than 40%. In further testing, 169 extracts were tested for cancer cell growth inhibition. In this study, 14 extracts were found to be active in inhibiting prostate cancer cells.

From among the active extracts, those from Ganoderma lucidum were found to be the most effective in inhibiting the function of the androgen receptor and controlling vital development of cancerous cells. "The results of this research are particularly interesting from a commercial aspect.

Potential possibilities exist to establish research and development of bioactive metabolites from Ganoderma lucidum that could yield an anti-prostate cancer drug," remarked Dr. Zaidman.

 
 
 
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