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Recent News and Articles on the Keywords: follow-up colonoscopy + help prevent + cancer  Related to the article below (Last Update: 5/13/2008)

AACR: Drug Duo Linked to Major Drop in High-Risk Adenoma Recurrence
MedPage Today, NJ - Apr 15, 2008
Patients had follow-up colonoscopy three years after randomization or off study. The primary outcome was the rate of adenoma recurrence. ...
A cancer leaves few to lobby
Pittsburgh Post Gazette, PA - Apr 13, 2008
"We don't have a Pap smear, we don't have a colonoscopy, we don't have a PSA test for pancreatic cancer," said Dr. Anirban Maitra, a pancreatic cancer ...
Preventing the Unpredicted: Managing Violence Risk in Mental ...
WRAL.com, NC - Apr 17, 2008
Optimizing treatment for all patients will help prevent violence by the few who pose a risk of violence, even when such patients are not identified in ...
Source: Google News

Prevention of Colorectal Cancer by Colonoscopic Polypectomy -
SJ Winawer, AG Zauber, MN Ho, MJ O'Brien, LS … - New England Journal of Medicine, 1993 - content.nejm.org
... is based on the belief that this will prevent colorectal cancer. ... The patients
subsequently underwent periodic colonoscopy during an average follow-up of 5.9 ...

A systematic review of the effects of screening for colorectal cancer using the faecal occult blood … -
B Towler, PG Les Irwig, J Kewenter, D Weller, C … - BMJ: British Medical Journal, 1998 - pubmedcentral.nih.gov
... Colonoscopy rates were lower for the trials in ... necessary quality of screening and
follow up be achieved ... We thank Philippa Middleton for help with literature ...

Is virtual colonoscopy a cost-effective option to screen for colorectal cancer? -
A Sonnenberg, F Delco, P Bauerfeind - American Journal of Gastroenterology, 1999 - Blackwell Synergy
... The most reliable data regarding follow-up compliance with colonoscopy ... screening
programs using CT colonography or colonoscopy to prevent colorectal cancer. ...

… Trial of Aspirin to Prevent Colorectal Adenomas in Patients With Previous Colorectal Cancer. -
RS Sandler, S Halabi, JA Baron, S Budinger, E … - Obstetrical & Gynecological Survey, 2003 - obgynsurvey.com
... Although these small series with short follow up are reassuring, more ... he or she might
not be as available to help with these ... Endometrial Cancer: Results From a ...

Colorectal cancer screening: Clinical guidelines and rationale -
SJ Winawer, RH Fletcher, L Miller, F Godlee, MH … - Gastroenterology, 1997 - Elsevier
... of the criteria. Genetic counseling is needed to help the pa- Adenomatous Polyposis ...
removed at colonoscopy should have an examination ... If the first follow-up ...

Colorectal Cancer Screening Scientific Review -
JME Walsh, JP Terdiman - JAMA, 2003 - Am Med Assoc
... The optimal means to prevent colorectal cancer ... The National Cancer Institute is now
sponsoring a ... is attributable to the performance of follow-up colonoscopy. ...

Is there endoscopic capacity to provide colorectal cancer screening to the unscreened population in … -
LC Seeff, DL Manninen, FB Dong, SK Chattopadhyay, … - Gastroenterology, 2004 - Elsevier
... only necessary endoscopy would be follow-up colonoscopy for positive ... A screening
colonoscopy program would require 10 ... finer estimates that can help guide local ...

Cost-Effectiveness of Colonoscopy in Screening for Colorectal Cancer -
A Sonnenberg, F Delco, JM Inadomi - Annals of Internal Medicine, 2000 - annals.highwire.org
... of initial, repeated, and follow-up compliance were ... effective screening method to
prevent colorectal cancer. ... total cost of screening, colonoscopy represents a ...

A Quarter Century of Colorectal Cancer Screening: Progress and Prospects -
SJ Winawer - Journal of Clinical Oncology, 2001 - jco.ascopubs.org
... less intense or more intense follow-up surveillance, respectively. ... The advent of
colonoscopy and polypectomy and ... of carcinogenesis that can help us understand ...

Colorectal Cancer in Patients Under Close Colonoscopic Surveillance -
DJ Robertson, ER Greenberg, M Beach, RS Sandler, D … - Gastroenterology, 2005 - Elsevier
... of cancer (and adenoma) at the start of follow-up. ... estimate of the efficacy of
colonoscopy would require a ... note that the biases, which prevent valid comparison ...

Source: Google Scholar

Regular colonoscopy with follow-up treatment if needed can help prevent colon cancer in patients with ulcerative colitis, new research suggests. Likewise, the use of anti-inflammatory drugs, such as aspirin and ibuprofen, seems to reduce the risk as well.

By contrast, the presence of "pseudopolyps" in the colon seems to raise the risk of cancer.

Ulcerative colitis is one of two principal inflammatory bowel diseases, the other one being Crohn's disease. With the disease, severe inflammation can occur throughout the colon (also called the large intestine) resulting in pain and bloody diarrhea. Pseudopolyps, a common occurrence with the disease, look like real polyps, but are actually the result of inflammation that surrounds a small portion of intestine.

People with ulcerative colitis are known to be at increased risk for colon cancer and the only way to completely eliminate this risk is to remove the colon and rectum, an operation that most patients want to avoid. Thus, there is a need to identify risk factors for colon cancer in such patients to prevent the disease or at least diagnosis it at an early, treatable stage.

There are limited data regarding the risk factors for colorectal cancer in ulcerative colitis patients, Dr. Edward V. Loftus, from the Mayo Clinic in Rochester, Minnesota, and colleagues note in the journal Gastroenterology. Regular colonoscopy and a commonly used drug called 5-ASA could potentially reduce the risk, but these two factors have never been investigated in the same study.

The researchers assessed risk factors for colorectal cancer by analyzing data from 188 ulcerative colitis patients with the cancer and 188 similar patients without it.

A history of pseudopolyps was tied to a 2.5-fold increased risk of colorectal cancer, the report indicates.

Most of the other factors studied had the opposite effect. Surveillance colonoscopy, smoking, and use of steroids, aspirin, NSAIDs (ibuprofen, etc), and 5-ASA all seemed to protect against colon cancer with risk reductions ranging from 50 to 90 percent. After 5 years, however, 5-ASA use was no longer significantly linked to a reduced risk.

Previous reports have also suggested that NSAIDs, steroids and smoking have protective effects against ulcerative colitis-related cancer. The common reason appears to be that each has anti-inflammatory effects that reduce the risk of cancer.

"These results suggest that, in a population matched for extent and duration of chronic ulcerative colitis, surveillance colonoscopy and use of anti-inflammatory medications may reduce the risk of cancer," the authors conclude.

SOURCE: Gastroenterology, June 2006.

Copyright © 2006 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

New Method Gauges Weight-Loss Surgery Risk

Five key characteristics may single out those patients most at risk for fatal complications from gastric bypass weight-loss surgeries, researchers report.

Gastric bypass surgery is a procedure performed on the morbidly obese to help them lose weight by manipulating the size of their stomachs. After surgery, patients' stomachs can only hold small amounts of food, preventing overeating and stimulating more quickly the feeling of fullness.

While considered a safe procedure, gastric bypass does come with risks.

"Our findings show that for the low-risk group of patients, gastric bypass surgery is a very safe option. For those patients in the highest risk category, we should look at performing lower-risk or a number of smaller procedures to reduce the potential risk," study author Dr. Eric DeMaria, director of bariatric surgery at Duke University Medical Center, said in a prepared statement.

However, before this study, there was "no clinically useful system to help determine which patients would be at highest risk of dying after gastric bypass surgery," DeMaria said. "We developed a scoring system that is based on five easy-to-identify patient characteristics that can help us decide whether or not a specific patient is a good candidate for surgery and what the probable risks would be."

To devise the scoring system, a team of Duke surgeons studied data on outcomes of 2,075 bariatric surgery patients treated at Virginia Commonwealth University in Richmond between 1995 and 2004.

Thirty-one of the patients died within 90 days of their surgery. Based on these patients' histories, the researchers found that five characteristics increased the risk of death or complications from bariatric surgery:

  • BMI (body mass index -- a calculation of weight versus height) of higher than 50. The normal range is between 18.5 and 25.
  • Being male.
  • Hypertension -- the condition is typically related to cardiovascular diseases, which can also increase risk.
  • Pulmonary embolus [clot] risk -- if patients have had or are at risk for having a blood clot in the lung, their risk may be increased.
  • Being over the age of 45.

"In using our system, each one of the five characteristics is worth one point. Those patients with a score of zero are at the least risk, while those with five points are at the highest risk," DeMaria said.

Only three of the 957 patients in the study who were classified as low-risk died -- a mortality rate of just 0.31 percent -- while 19 out of 999 (1.9 percent) medium-risk patients died. In contrast, nine out of the 119 high-risk patients died -- a mortality rate of 7.56 percent, the researchers noted.

The findings could have implications for treatment decision-making, DeMaria said.

"Many people see gastric bypass surgery as an option to use only when all other approaches to weight loss have failed," he explained. "However, our system shows that this strategy may need to be reconsidered. If patients put off surgery while they attempt other therapies that ultimately don't work, over time, they risk moving into a higher-risk category as they gain more weight, get older or develop hypertension. In these cases, delays can make surgery even riskier."

DeMaria presented the results of the study and the new scoring system at the annual meeting of the American Society for Bariatric Surgery, in San Francisco.

More information

Head to the Columbia University Department of Surgery to read more about gastric bypass surgery.

 
 
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