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Recent News and Articles on the Keywords: lung cancer + benefits unclear + cancer  Related to the article below (Last Update: 5/5/2008)

Synergistic Growth Inhibitory Effect Of Herbal Extracts Against ...
Science Daily (press release) - Apr 30, 2008
Recent reports show that combination chemotherapy is a superior modality and that naturally occurring dietary supplements with known anti-cancer properties ...
BRCA Breast Cancer Mutations & MRI Scans; Bladder Cancer ...
Men's News Daily, CA - Apr 20, 2008
Therefore, it remains unclear if the anti-cancer properties of dietary isothiocyanates seen in a Petri dish or in laboratory animals will actually translate ...
MannKind CEO still betting on inhaled insulin
Los Angeles Times, CA - Apr 9, 2008
In its trial, Pfizer said six of the 4740 patients treated with Exubera developed lung cancer, compared with one of 4292 patients not treated with the drug. ...MNKD

Nigerian Tribune
Natural Health
Nigerian Tribune, Nigeria - Apr 23, 2008
Phellinus linteus has been shown in other research to effectively kill skin, lung and prostate cancer cells but this latest research on breast cancer cells ...
New Details On Scientology?s Link In Norwegian Student Kaja Ballo ...
Glosslip, OH - Apr 16, 2008
Filmsky, Betty cancer John Filinsky?s first wife, Betty Filinsky, was first Solo NOTS completion and died of lung cancer, I think right after her ?world ...
Some patients rushed to repeat colonoscopies
Chicago Daily Herald, IL - Apr 27, 2008
The drug Panzem NCD -- already used against lung and brain cancers -- also appears to eradicate and prevent the spread of cancerous breast cells, ...

Muskegon Chronicle - MLive.com
Local vet among thousands exposed to A-bomb radiation
Muskegon Chronicle - MLive.com, MI - Apr 26, 2008
... based on the colon cancer -- a fairly common outcome of radiation poisoning. He also gets VA benefits for an unrelated lung condition caused by asbestos ...
Source: Google News

… in previously treated patients with refractory advanced non-small-cell lung cancer: results from a …
N Thatcher, A Chang, P Parikh, J Rodrigues Pereira … - The Lancet, 2005 - Elsevier
... Cancer pain, 39 (4%), 7, 36 (6%), 3. ... of patients experiencing events of interstitial
lung disease type ... 20 The reasons why no significant survival benefit was found ...

Lung Cancer Mortality in the Mayo Lung Project: Impact of Extended Follow-up -
PM Marcus, EJ Bergstralh, RM Fagerstrom, DE … - jnci, 2000 - jnci.oxfordjournals.org
... when the underlying cause of death was unclear. ... erroneously classified as deaths
not due to lung cancer. ... help determine whether a mortality benefit was missed ...

Lung Cancer Screening With Helical Computed Tomography in Older Adult Smokers A Decision and Cost- … -
PJ Mahadevia, LA Fleisher, KD Frick, J Eng, SN … - JAMA, 2003 - Am Med Assoc
... 19 However, these findings are of unclear clinical significance ... are doubtful of a
mortality benefit due to ... CT as a screening test for lung cancer are beginning ...

… After Gefitinib Treatment in Patients With Non-Small-Cell Lung Cancer With Postoperative Recurrence -
T Mitsudomi, T Kosaka, H Endoh, Y Horio, T Hida, S … - Journal of Clinical Oncology, 2005 - jco.ascopubs.org
... four patients with recurrent non?small-cell lung cancer. ... It has been unclear which
patients respond to ... to concentrate patients with benefits from gefitinib ...

Matrix Metalloproteinase Inhibitors and Cancer-Trials and Tribulations -
LM Coussens, B Fingleton, LM Matrisian - Science, 2002 - sciencemag.org
... maximum tolerated doses without the benefit of knowing ... pancreatic adenocarcinoma
and small-cell lung cancer) in predicting ... a standard in the cancer armament is ...

Dying of lung cancer or cardiac failure: prospective qualitative interview study of patients and … -
SA Murray - BMJ, 2002 - pubmedcentral.nih.gov
... support of a hospital based lung specialist cancer ... patients and their carers would
benefit from proactive ... lessons learnt from caring for cancer patients?an ...

… Copy Numbers Predict Gefitinib Sensitivity in Patients With Recurrent Non-Small-Cell Lung Cancer -
T Takano, Y Ohe, H Sakamoto, K Tsuta, Y Matsuno, U … - Journal of Clinical Oncology, 2005 - jco.ascopubs.org
... copy numbers on EGFR-mutant NSCLC was unclear. ... of the IRESSA Survival Evaluation
in Lung Cancer (ISEL) trial ... of the trial suggested survival benefits in never ...

Adenoviral-Mediated p53 Gene Transfer to Non-small Cell Lung Cancer Through Endobronchial Injection* -
D Weill, M Mack, J Roth, S Swisher, S Proksch, J … - Chest, 2000 - Am Coll Chest Phys
... patients who receive a diagnosis of non-small cell lung cancer (NSCLC) present ... achieved
a subjective response, although the duration of benefit is unclear. ...

… indicated following complete response to induction therapy in small cell lung cancer: Results of a … -
A Gregor, A Cull, RJ Stephens, JA Kirkpatrick, JR … - European Journal of Cancer, 1997 - Elsevier
... morbidity and whether PC1 influences survival are unclear. ... of cra- nial relapse of
small cell lung cancer. ... has conclusively shown a survi- val benefit for PCI. ...

Treatment of advanced non-small-cell lung cancer patients with ECOG performance status 2: results of … -
C Gridelli, A Ardizzoni, T Le Chevalier, C … - Annals of Oncology, 2004 - Eur Soc Med Oncology
... for advanced NSCLC, but it is still unclear if the ... The benefits of chemotherapy in
patient subgroups with unresectable non-small-cell lung cancer. ...

Source: Google Scholar

Benefits of surgery for lung cancer unclear

Evidence from clinical trials neither supports nor refutes a benefit for surgery as a treatment for the most common type of lung cancer, non-small cell lung cancer or NSCLC, according to findings from the first-ever systematic review to address this topic.

The review, which appears in the medical journal Thorax, involved 11 trials that included data on patients who underwent surgery for NSCLC. Six of the studies, which included more than 1000 patients, focused on surgery vs. no surgery, while the remaining five, which included over 1100 patients, compared various surgical approaches.

As noted, the results generally showed no survival advantage or disadvantage for surgery compared with non-surgical therapy, Dr. R. L. Manser, from St. Vincent's Hospital Melbourne in Victoria, Australia, and colleagues report.

In one small study, however, chemotherapy followed by surgery rather than by radiation treatment did seem to improve survival of patients with more advanced disease.

In terms of the surgical approach, more extensive tissue removal was often linked to better outcomes. For example, in a pooled analysis of three studies, the survival rate at four years was improved with a complete removal of lymph nodes. In another study, removal of an entire lobe of the lung appeared to reduce recurrence of early-stage disease compared with limited resection.

"It is difficult to draw conclusions" about the efficacy of surgery for NSCLC, the authors state. The results of ongoing trials may help clarify this issue, they add.

SOURCE: Thorax

Older dads seem to have sicklier babies

Findings from a recent study indicate that new fathers in their 40s and 50s are slightly more likely to have an infant with a low Apgar score than fathers in their 20s.

The Apgar score, which was first created in 1952, rates the newborn on five parameters: respiratory effort, heart rate, reflex irritability, muscle tone, and skin color with a value of 0 to 2 (worst to best) for each. Thus, a total score of 10 is optimal. The score is calculated at 1 and 5 minutes after birth.

In the last few years, several reports have linked advanced paternal age with various adverse pregnancy outcomes, including fetal death and preterm birth. However, little was known about the impact, if any, on the physical condition of the infant at birth.

To investigate, Dr. Yuelian Sun, from the University of Aarhus in Denmark, and colleagues analyzed data from more than 70,000 couples who had a first infant born between 1980 and 1996.

The team reports in the research journal Epidemiology that, compared with fathers in their 20s, those between 45 and 49 years of age and those 50 years of age or older were 64 percent and 49 percent more likely, respectively, to have an infant with a 1-minute Apgar score between 1 and 3.

Moreover, fathers 45 years of age or older were at increased risk of having an infant with a 5-minute Apgar score of less than 7.

"The biologic link between advanced paternal age and low Apgar scores is unknown," Sun and colleagues say. However, some studies have shown that "expression of specific paternal genes is crucial for the placental development and that chromosomal aberrations tend to increase with paternal age."

SOURCE: Epidemiology

Copyright © 2006 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

Drug-resistant E. coli likely started in poultry

The food-contaminating bug E. coli -- which can cause diarrhea, urinary tract infections and more severe illness in humans -- appears to be developing resistance to antibiotics called fluoroquinolones in chickens, a study shows.

The problem is arising largely because of antibiotic treatment of the animals, which forces the microbes to mutate and become resistant. Food-borne resistant E. coli can then be transmitted to humans.

Action to interrupt the transmission of resistant bacteria from animals to humans may become necessary, the researchers say. Such measures could include "limiting antimicrobial use in food animals, adopting more hygienic food-processing and distribution practices, irradiating food, and improving kitchen hygiene."

In the late 1990s, Dr. James R. Johnson of the University of Minnesota in Minneapolis and colleagues obtained E. coli from 35 blood samples and 33 fecal samples from patients with food poisoning seen at a hospital in Barcelona. The investigators also evaluated 49 fecal specimens from chickens at three slaughterhouses in the area.They found that 30 of the human specimens and 30 of the chicken specimens were resistant to Cipro, a type of fluoroquinolone antibiotic, according to their report in The Journal of Infectious Diseases.

Resistant human isolates resembled the resistant chicken isolates in terms of virulence and their DNA sequence."These data provide the strongest molecular evidence available to date for a food (specifically chicken) source for potentially pathogenic fluoroquinolone-resistant E. coli in humans," Johnson and his team write.They emphasize that even though the resistant organisms from humans and chickens were less virulent than antibiotic-susceptible human E. coli isolates, "they are not benign." The resistant isolates are still capable of causing blood poisoning and acute urinary tract infections in humans.Once these findings are confirmed in other studies, the researchers conclude, they will "provide a compelling rationale for efforts to eliminate such organisms from the food supply."

SOURCE: Journal of Infectious Diseases
 
 
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