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Recent News and Articles on the Keywords: sex differences + study shows + gene  Related to the article below (Last Update: 5/5/2008)

Men from Mars, women from Venus? Not really
Hindu, India - Apr 17, 2008
The set of neurons that control this behaviour make the products of the fru (or 'fruitless') gene a key sex-determining factor in the nervous system. ...
Actress to perform while play's creator watches
The Daily Collegian Online, PA - Apr 16, 2008
In this scene, Mathanson's character is having sex with her boyfriend in a pick-up truck. Where:Thursday, Waring Commons study lounge. ...
Source: Google News

… receptor messenger RNA expression in rat hypothalamus as a function of genetic sex and estrogen dose -
AH Lauber - Endocrinology, 1991 - Endocrine Soc
... Thus, the second study shows sex differences and brain-region ... These findings show
that differences in ... the possibility of sex differences in concentrations of ...

Sex Differences in Coronary Heart Disease Why Are Women So Superior? The 1995 Ancel Keys Lecture -
E Barrett-Connor - Circulation, 1997 - Am Heart Assoc
... during specific tasks; these studies show that men ... are results from an uncontrolled
study of female ... pituitary-adrenal axis suggest interesting sex differences. ...

[PDF] Sex differences in the effects of testosterone and its metabolites on vasopressin messenger RNA … -
GJ De Vries, Z Wang, NA Bullock, S Numan - J Neurosci, 1994 - umass.edu
... The present study shows that, in castrated males, the effects ... of E. Finally, there
may be sex differences in the ... of gonadal steroid receptors and the AVP gene. ...
-

… Carotid Atherosclerosis Principal Results of the European Lacidipine Study on Atherosclerosis (ELSA … -
A Zanchetti, MG Bond, M Hennig, A Neiss, G Mancia, … - Circulation, 2002 - Am Heart Assoc
... values), smoking (smokers, exsmokers, nonsmokers), sex, and diabetes. ... a mean
treatment-related difference of 0.1079 ... treated patients ended the study with fewer ...

… Disease in Heterozygous Familial Hypercholesterolemia Patients With the Same LDL Receptor Gene … -
J Ferrieres, J Lambert, S Lussier-Cacan, J … - Circulation, 1995 - Am Heart Assoc
... patients with CAD had higher levels of TG by univariate analysis, but this difference
disappeared in ... Conclusions Our study shows a sex-specific lipoprotein ...

Age and sex differences in the relationship between inherited and lifestyle risk factors and … -
E Stensland-Bugge, KH B?naa, O Joakimsen - Atherosclerosis, 2001 - Elsevier
... The present study shows that a family history of ... susceptibility for atherosclerosis
or sex differences in the ... The present study suggests that fibrinogen levels ...

Ethnic differences in invasive management of coronary disease: prospective cohort study of patients … -
G Feder, AM Crook, P Magee, S Banerjee, AD Timmis, … - BMJ: British Medical Journal, 2002 - pubmedcentral.nih.gov
... Figure 4 shows that there were no differences in ... Footnotes. Funding: The ACRE study
was established with ... Race and sex differences in the management of coronary ...

Estrogen Receptor a Gene Polymorphisms and Risk of Myocardial Infarction -
SCE Schuit, HHS Oei, JCM Witteman, CH Geurts van … - JAMA, 2004 - Am Med Assoc
... Given the substantial differences in hormone dynamics between men ... women, we chose
to stratify our analysis by sex. An intriguing aspect of this study is that ...

Sex Differences in Circulating Human Leptin Pulse Amplitude: Clinical Implications 1 -
J Licinio, AB Negrao, C Mantzoros, V Kaklamani, ML … - Journal of Clinical Endocrinology & Metabolism, 1998 - Endocrine Soc
... this study might be explained by sex differences in the ... However, an animal study
that carefully measured amount ... external cues and masking events, show that the ...

The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster -
W Jin, RM Riley, RD Wolfinger, KP White, G … - Nat Genet, 2001 - palgrave-journals.com
... As many Drosophila traits are sex-biased and show sex genotype interactions,
differences at the ... the most interesting effects in this study are the ...

Source: Google Scholar

Gene study shows sex differences go deep

Thousands of genes behave differently in the same organs of males and females, researchers reported on Friday, a finding that may help explain why men and women have different responses to drugs and diseases.

Their study of brain, liver, fat and muscle tissue from mice showed that gene expression -- the level of activity of a gene -- varied greatly according to sex.

The same is almost certainly true of humans, the team at the University of California Los Angeles reported.

"This research holds important implications for understanding disorders such as diabetes, heart disease and obesity, and identifies targets for the development of gender-specific therapies," said Jake Lusis, a professor of human genetics who worked on the study.

Writing in the August issue of Genome Research, the researchers said that even in the same organ, scores of genes varied in expression levels between the sexes.

The smallest differences were in brain tissue, they found.

"We saw striking and measurable differences in more than half of the genes' expression patterns between males and females," said Dr. Thomas Drake, a professor of pathology. "We didn't expect that. No one has previously demonstrated this genetic gender gap at such high levels."

Xia Yang, a postdoctoral fellow in cardiology who led the study, said the implications are important.

"Males and females share the same genetic code, but our findings imply that gender regulates how quickly the body can convert DNA to proteins," Yang said in a statement. "This suggests that gender influences how disease develops."

In liver tissue, the findings imply male and female livers function the same, but at different rates.

"Our findings in the liver may explain why men and women respond differently to the same drug," Lusis said.

"Studies show that aspirin is more effective at preventing heart attack in men than women. One gender may metabolize the drug faster, leaving too little of the medication in the system to produce an effect."

Yang added, "Many of the genes we identified relate to processes that influence common diseases. This is crucial, because once we understand the gender gap in these disease mechanisms, we can create new strategies for designing and testing new sex-specific drugs.

Copyright © 2006 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

Women students unaware of lifestyle links to cancer

Most female students are unaware that lifestyle factors can influence their risk of developing breast cancer, according to a survey released on Monday.

A poll of more than 10,000 students in 23 countries showed more than half knew heredity was a risk factor. But less than five percent realised that eating and drinking too much alcohol and not getting enough exercise also had an impact. "It is very worrying that information about being overweight, having a high alcohol intake and taking little exercise has simply not been effectively communicated to young women in any of the countries we surveyed," Professor Jane Wardle, of the charity Cancer Research UK, who headed the research team, said.

American students were the most aware that lifestyle could place a role in breast cancer. Ten percent of Americans questioned in the poll published in the European Journal of Cancer knew alcohol was a risk factor compared to four percent in England, which was less than in Greece, Spain and Colombia.

Female students in Iceland, Ireland, Greece and South America were better informed about the link between lack of exercise and breast cancer than English students. "The results of this study suggest that students could be overestimating the impact of genetic factors and are certainly underestimating the importance of lifestyle factors," Wardle added. Breast cancer is one of the most common cancers in women. More than a million cases occur worldwide each year, according to the International Agency for Research on Cancer in Lyon, France. The disease develops most often in older women. Factors that can also increase a woman's risk of the breast cancer include having a mother or close relative with the disease, early puberty, late menopause and not having any children. The contraceptive pill and hormone replacement therapy (HRT) after the menopause may also cause an increase in risk but it gradually returns to normal once a woman stops taking them. Students in countries in Africa, Asia, Europe and North and South America took part in the study.

Copyright © 2006 Reuters Limited. All rights

 
 
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