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Recent News and Articles on the Keywords: marijuana + changes + lung  Related to the article below (Last Update: 5/13/2008)

THV Extra: Breaking Meth's Cruel Addiction
Today's THV, AR - Apr 30, 2008
The number one drug problem for many counties across the state is not cocaine or marijuana, but methamphetamine. That's according to the Drug Enforcement ...
Bend attempted murder case in judge's hands
KTVZ, OR - Apr 23, 2008
Now with history suggesting that this is related to his methamphetamine use, that may have led to brain changes that precipitated this. ...
Pack that in a bill and smoke it
Times Milwaukee (subscription), WI - Apr 24, 2008
The US war on drugs primarily focuses its attacks on marijuana. The Sentencing Project, which works for changes in sentencing law and policy, ...
Source: Google News

[PDF] Adverse effects of cannabis -
W Hall, N Solowij - Lancet, 1998 - letsgethigh.com
... smoking, the similarity between tobacco and cannabis smoke, and the evidence that
cannabis smoking produces histopathological changes that precede lung cancer, ...
-

Recent Trends in Lung Cancer Mortality in the United States -
A Jemal, KC Chu, RE Tarone - jnci, 2001 - jnci.oxfordjournals.org
... Accumulating evidence from studies of histopathologic and molecular changes in lung
tissue of smokers suggests that marijuana smoking could increase the risk ...

Large lung bullae in marijuana smokers. -
MK Johnson, RP Smith, D Morrison, G Laszlo, RJ … - Thorax, 2000 - pt.wkhealth.com
... disease of the lung or vanishing lung syndrome) have been ... emphysema which are the
typical changes associated with a ... 2 Whilst marijuana smoking has been seen to ...

A longitudinal study of the effects of tobacco and cannabis exposure on lung function in young … -
DR Taylor, DM Fergusson, BJ Milne, LJ Horwood, TE … - Addiction, 2002 - pt.wkhealth.com
... Although the magnitude of the changes in lung function associated with cannabis
exposure may not be clinically significant, the findings suggest that if ...

Comparing cannabis with tobacco Smoking cannabis, like smoking tobacco, can be a major public health … -
J Henry, W Oldfield, O Kon - BMJ, 2003 - pubmedcentral.nih.gov
... 7 ? 9 Premalignant changes have been shown in the pulmonary epithelium, and there
are reports of lung, tongue, and other cancers in cannabis smokers. ...

Respiratory health effects of cannabis: Position Statement of The Thoracic Society of Australia and … -
DR Taylor, W Hall - Internal Medicine Journal, 2003 - Blackwell Synergy
... Early studies confirm that even after short-term but fairly heavy exposure to cannabis
smoke, small but significant changes in lung function occur. ...

[PDF] Effects of varying marijuana potency on deposition of tar, and D 9-THC in the lung during smoking -
P Matthias, DP Tashkin, JA Marques-Magallanes, JN … - Pharmacol Biochem Behav, 1997 - ukcia.org
... amount of tar and THC retained in the lung, COHb boost, peak change in heart rate,
and peak level of intoxication for each potency of marijuana smoked are ...
-

[PDF] Effects of Habitual Use of Marijuana and/or Cocaine on the Lung -
DP Tashkin, S Fligiel, TC Wu, H Gong Jr, RG … - Research Findings on Smoking of Abused Substances, 1990 - bib1lp1.rz.tu-bs.de
... with no or minimal lung function abnormality, indicating that habitual marijuana
smoking fre ... injury manifested by extensive morphologic changes at a ...

Human pulmonary histopathological changes from marijuana smoking.
RR Morris - J Forensic Sci, 1985 - ncbi.nlm.nih.gov
... This report calls attention to the accelerated pathological changes in the lungs
from marijuana smoking as compared to tobacco smoking leading to pulmonary ...

Marijuana as a Potential Respiratory Tract Carcinogen: A Retrospective Analysis of a Community … -
FM TAYLOR III - Southern Medical Journal, 1988 - smajournalonline.com
... marijuana-induced morphologic changes.16 In experiments with rats and automatic
smoke inhalers, inflammatory Site Average Age of Men Average Age of Women Lung ...

Source: Google Scholar

Marijuana tied to precancerous lung changes

Smoking marijuana can cause changes in lung tissue that may promote cancer growth, according to a review of decades of research on marijuana smoking and lung cancer.

Still, it is not possible to directly link pot use to lung cancer based on existing evidence.More than 40 percent of Americans 12 and older have tried marijuana at least once, Dr. Reena Mehra of Case Western Reserve University in Cleveland, Ohio and her colleagues point out. "Given the widespread use of marijuana, its use for what are believed to be medicinal purposes, and the increasing abuse and dependence on this substance, it is important to examine potential adverse clinical consequences," they write in the Archives of Internal Medicine.

To investigate whether marijuana smoking might lead to precancerous changes in the lungs or lung cancer, Mehra and her team reviewed 19 studies of the topic.

Analyses of sputum and lung tissue performed in some of these studies found more cancer-promoting changes in pot smokers than in cigarette smokers or non-smokers, including oxidative stress, dysfunction of tumor-fighting cells, changes in tissue structure and DNA alterations, the researchers report.

However, none of the studies they analyzed found evidence that marijuana smoking actually caused lung cancer, after factoring in the effects of tobacco use.

"We must conclude that no convincing evidence exists for an association between marijuana smoking and lung cancer based on existing data," Mehra and her team write.

Nevertheless, they add, the precancerous changes seen in studies included in their analysis -- as well as the fact that marijuana smokers generally inhale more deeply and hold smoke in their lungs longer than cigarette smokers, and that marijuana is smoked without a filter -- do suggest that smoking pot could indeed boost lung cancer risk. It is known, they add, that marijuana smoking deposits more tar in the lungs than cigarette smoking does.

The failure to find a marijuana-lung cancer link may have been due to methodological flaws in existing research, rather than the absence of such a link, the researchers say. Doctors should advise their patients that marijuana does indeed have potential adverse effects, they conclude, including causing precancerous changes in the lungs.

SOURCE: Archives of Internal Medicine

 

Leg length linked to heart disease risk

Having longer legs may put you at lower risk of heart disease, new findings show.

In an analyses of data from 12,254 men and women aged 44 to 65, Dr. Kate Tilling of the University of Bristol in the UK and colleagues found a direct association between leg length and intimal-medial thickness (IMT), a measurement of the thickness of blood vessel walls used to detect the early stages of atherosclerosis, or hardening of the arteries. The longer a person's legs, they found, the thinner their carotid artery walls were, indicating less buildup of deposits within these blood vessels and a lower risk of heart disease and stroke.

Leg length is strongly affected by early life factors, Tilling and her team point out in their article in the American Journal of Epidemiology. For example, studies have linked breastfeeding, high-energy diets at age two and four years, and affluent childhood circumstances to longer leg length.

To investigate whether leg length might also be related to early signs of heart and blood vessel disease -- which would in turn support a connection between early life factors and heart attack and stroke risk -- the researchers compared leg length to IMT of the carotid artery in a group of men and women participating in a large study of atherosclerosis risk. They estimated leg length by subtracting a person's height when seated from his or her total height.Leg length was directly linked to IMT, the researchers found, with the relationship being strongest for black men and weakest for black women. The study "provides some support for the hypothesis that early life factors, such as breastfeeding and childhood nutrition, which are associated with greater prepubertal linear growth, may reduce cardiovascular disease risk," Tilling and her colleagues conclude.

SOURCE: American Journal of Epidemiology

Metabolic syndrome predicts breast cancer relapse

A cluster of characteristics that include high cholesterol, obesity, high blood sugar and high blood pressure -- dubbed metabolic syndrome -- has been linked previously to the development of diabetes and heart disease. Now, Italian researchers say it is "an important prognostic factor" in the recurrence of breast cancer.

"Previous studies suggested that several aspects of metabolic syndrome, such as low HDL-cholesterol, high blood glucose, high triglycerides, abdominal obesity, hypertension, and high levels of insulin ... are associated with breast cancer risk," Dr. Patrizia Pasanisi told Reuters Health."However, this is the first report addressing the issue of whether breast cancer prognosis is affected by metabolic syndrome," said the researcher from the Istituto Nazionale Tumori in Milano.

Pasanisi and colleagues evaluated 110 women who underwent surgery for breast cancer at least 12 months earlier and who volunteered to participate in a year-long dietary intervention study.

The metabolic syndrome was diagnosed at the start of the study in 16 women, the team reports in the International Journal of Cancer. After 5.5 years of follow-up, 32 women developed breast cancer recurrences, including 8 of the 16 with metabolic syndrome.Women with metabolic syndrome were three times more likely to have a recurrence of breast cancer as women without the syndrome."If the predictive value of metabolic syndrome is confirmed," said Pasanisi, "we think that its evaluation should become part of the standard diagnostic workup of breast cancer patients, and dietary intervention to control the syndrome should be considered."

SOURCE: International Journal of Cancer
 
 
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