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Recent News and Articles on the Keywords: breast cancer + lab mice + chemical  Related to the article below (Last Update: 5/13/2008)

Stanford researcher stumbled on potential chemical threat
San Jose Mercury News,  USA - May 6, 2008
"I'm not an alarmist, and I'm not saying that drinking from plastic bottles will cause breast cancer," said Feldman, who advises his own children not to put ...
A Perfect Storm
RedOrbit, TX - May 10, 2008
The study showed the chemical mimicked the effects of the female hormone estrogen in lab rats. The effects - at what Vom Saal said were levels thousands of ...
Criticism mounts over ingredient in plastics
Belleville News Democrat,  USA - May 4, 2008
In Rebecca Roberts' lab at Ursinus College, experiments involving bisphenol A are conduted by students (from left) Emily Mercadanite, Danielle Indelicato, ...
ALSO NOTED: Genetic mutation explains beta blocker failure ...
FierceBioResearcher, DC - Apr 29, 2008
Article Iceland's deCODE Genetics identified two new genetic mutations linked to breast cancer and says it will swiftly develop a new genetic test for women ...
Safety of plastics chemical questioned
Arizona Republic, AZ - Apr 26, 2008
The compound, bisphenol A, or BPA, has been linked to breast and prostate cancer, behavioral disorders and reproductive-health problems in lab animals. ...
How What and How Much We Eat (And Drink) Affects Our Risk of Cancer
Newswise (press release) - Apr 13, 2008
Groups of female mice received 25 nmol of 7,12-dimethylbenz(a)anthracene (DMBA), a cancer inducing chemical, and were then placed on one of four dietary ...OTC:CTHP

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TGF-? signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases … -
JJ Yin, K Selander, JM Chirgwin, M Dallas, BG … - Journal of Clinical Investigation, 1999 - pubmedcentral.nih.gov
... for the Care and Use of Laboratory Animals. ... the third set of experiments, female
mice were inoculated ... II TGF-? receptor subunit in breast cancer cells altered ...

[PDF] … growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice -
YH Ju, CD Allred, KF Allred, KL Karko, DR Doerge, … - J Nutr, 2001 - fn.cfs.purdue.edu
... 7) and -independent (MDA 231) human breast cancer cells. ... 1993) AIN-93 purified diets
for laboratory rodents: final ... MCF-7 tumor variant in athymic mice by novel ...

Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis -
S Nandi, RC Buzman, J Yang - Proc Natl Acad Sci US A, 1995 - pubmedcentral.nih.gov
... Guzman, and J Yang Cancer Research Laboratory, University of ... cell proliferation in
pituitary isografted BALB/c mice. ... Estrogen-induced breast cancer in the rat. ...

Identifying chemical carcinogens and assessing potential risk in short-term bioassays using … -
RW Tennant, JE French, JW Spalding - Environmental Health Perspectives, 1995 - pubmedcentral.nih.gov
... French, and JW Spalding Laboratory of Environmental ... a familial syndrome of breast
cancer, sarcomas, and ... carcinogen-induced tumorigenesis in p53-deficient mice. ...

Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation -
M Johnsen, LR Lund, J Rrmer, K Almholt, K Danr - Current Opinion in Cell Biology, 1998 - Elsevier
... matrix metalloprotease-9 in vascular pericytes in human breast cancer. Lab Invest
1997, 77:345-355 ... polyomavirus middle T oncogene: a transgenic mouse model for ...

Chemical Carcinogen-Induced Tumorigenesis in Parous, Involuted Mouse Mammary Glands -
D Medina, GH Smith - jnci, 1999 - jnci.oxfordjournals.org
... Houston, TX; GH Smith, Laboratory of Tumor Immunology and Biology, National Cancer
Institute, Bethesda ... Breast cancer remains the major cancer among women ...

Breast cancer risk and environmental exposures -
MS Wolff, A Weston - Environmental Health Perspectives, 1997 - pubmedcentral.nih.gov
... stimulates the reproductive tract in immature female mice. ... p-dioxin (TCDD) in laboratory
animals. ... exposure as a potential etiologic factor in breast cancer. ...

… of a Dieldrin/Toxaphene Mixture in the Mouse Uterus, MCF-7 Human Breast Cancer Cells, and Yeast- … -
K Ramamoorthy, F Wang, IC Chen, JD Norris, DP … - Endocrinology, 1997 - Endocrine Soc
... or to differences in ER constructs used by either laboratory. ... ER-binding and functional
assays in the mouse uterus, MCF-7 human breast cancer cells, and in ...

[PDF] Modelling the molecular circuitry of cancer -
WC Hahn, RA Weinberg - Nature Reviews Cancer, 2002 - inka.mssm.edu
... introduced oncogenes will transform mouse cells,whereas ... that increasingly phenocopy
human cancer.Such models ... and testing of candidate chemical and biological ...
-

Transforming growth factor-bold beta 1 is a new form of tumor suppressor with true haploid … -
B Tang, EP B?ttinger, SB Jakowlew, KM Bagnall, J … - Nature Medicine, 1998 - nature.com
... 4 Pathology/Histotechnology Laboratory, Science Applications International ... in the
heterozygous mice did not ... with disease progression in human breast cancer. ...

Source: Google Scholar

Chemical Triggers Breast Cancer in Lab Mice

A chemical found in cleaning materials, textiles, plastics, paper and some personal-care products can trigger breast cancer, at least in lab animals, a new study has found. Since the early 1990s, experts have known that the chemical, called 4-nonylphenol, binds to estrogen receptors, said senior study author William Baldwin, an assistant professor of biological sciences at the University of Texas at El Paso.

In the liver, 4-nonylphenol stimulates an enzyme system that then boosts production of estriol, a hormone associated with breast cancer. The chemical also has an affinity for estrogen receptors in breast tissue that trigger growth, he said. "There have been a couple of studies in animals that showed a proliferation of mammary tissue when exposed to NP-4," Baldwin said. "This is believed to be the first study to show that if we carried out that enhanced proliferation for a longer period of time, it actually does lead to cancer in the lab animals."

Part of the problem is that the chemical, which mimics estrogen, may last longer in the body than natural estrogen, Baldwin theorized, but he added, "I have no evidence of this." The study appears in the July issue of the Journal of Applied Toxicology.

In the study, Baldwin and his team compared the effects of giving differing doses of the chemical and estrogen to mice. When they followed mice genetically engineered to readily develop breast cancer over 32 weeks, many of those given 4-NP developed breast cancer while those given equivalent doses of estrogen did not. Since the chemical is found in so many materials, should consumers be worried?

"I don't know if we can say that," Baldwin said. "The doses we used were much greater than what you would be exposed to, probably 100 to 1,000 times greater. [But] there might be more risk than we think." Much more research is needed, Baldwin said. "In 10 or 15 years, we will figure out if environmental estrogens are a cause or part of the cause for breast cancer," he said.

Baldwin and other experts estimate that established risk factors such as aging, early onset of periods, late menopause, delayed childbearing and genetics explain only about 25 percent to 50 percent of breast cancers, and that environmental exposure plays a big role. Brenda Salgado is program manager for Breast Cancer Action, a San Francisco-based organization that lobbies for environmental reforms, such as seeking legislation to label all carcinogens in cosmetics. She said that, while it's premature to give women advice based on just this study, they "should be conscious of chemicals that have an estrogenic effect and limit exposure to those chemicals."

Previous studies have found that exposure to these estrogen-like chemicals boost the risk of breast cancer, she said. The organization notes on its Web site that 70 percent of women with breast cancer have no known risk factors, suggesting that environmental forces play a major role.

More information

To learn more about breast cancer, visit the American Cancer Society.

 

Health Highlights: July 14, 2005

July 14, 2005 08:40:52 PM PST

Here are some of the latest health and medical news developments, compiled by the editors of HealthDay:

Rehnquist Discharged From Hospital, Denies Retirement Rumors

U.S. Chief Justice William Rehnquist was released from an Arlington, Va., hospital on Thursday after being treated for a high fever, the Associated Press said. Hours later, he issued a statement denying rumors of his pending retirement, the wire service said.

The 80-year-old Rehnquist suffers from thyroid cancer. He was hospitalized Tuesday evening for tests after complaining of a high fever, a court spokeswoman said. Rehnquist was first hospitalized in October for a tracheotomy that allowed him to breathe easier. He subsequently received chemotherapy and radiation.

"I want to put to rest the speculation and unfounded rumors of my imminent retirement," Rehnquist said in Thursday's statement obtained by the AP. "I am not about to announce my retirement. I will continue to perform my duties as chief justice as long as my health permits."

Speculation about his future heightened earlier this month when fellow Supreme Court Justice Sandra Day O'Connor said she was retiring, creating the court's first vacancy in 11 years.

Rehnquist has been on the court for 33 years.

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NIH Cites Ethical Violations Among Scientists

The U.S. National Institutes of Health has cited 44 government scientists who it says violated conflict-of-interest regulations by consulting for pharmaceutical firms, the Associated Press reported Thursday.

The agency investigated whether the scientists had properly listed their work for the drug companies on financial disclosure forms, whether their superiors had approved the work, and if they took personal leave to do private work, the wire service said.

Forty-four of 81 scientists investigated were found to have broken at least one NIH rule, while 37 others were found to be in compliance. The review was requested by the House Energy and Commerce Committee, which had been investigating alleged instances of conflict of interest that may have happened between 1999 and 2004.

NIH has since banned employees from consulting with drug and biotechnology companies. Of the 44 scientists found to be in violation of ethics rules, 36 are still employed at the agency and have been referred for possible disciplinary action, the AP reported.

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Use of Antipsychotic Drugs Rising in Nursing Homes: Report

More than one in four Medicare beneficiaries who live in nursing homes were given antipsychotic drugs in 2000-2001, the highest reported rate in nearly a decade, the Commonwealth Fund said in a report released Thursday.

In 2001, the report found, the government program spent more than $3 billion for antipsychotics, more than it spent on antibiotics, cardiovascular drugs, or antidepressants.

While newer-generation antipsychotics, often referred to as "atypicals," have been shown to be effective in treating schizophrenia, they are increasingly being prescribed in nursing homes for conditions such as memory problems, nonaggressive behaviors, or depression without psychotic symptoms, the researchers said in a statement.

The report cited growing instances of excessive dosing, "duplicative therapy" that resulted from administering antipsychotic and conventional drugs at the same time, and other unspecified uses deemed inappropriate.

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Painkiller Palladone Taken off Market

Citing potentially fatal reactions when the narcotic painkiller Palladone is taken with alcohol, the U.S. Food and Drug Administration on Wednesday ordered a halt to sales of the drug.

Drug maker Purdue Pharma agreed to stop U.S. sales of Palladone while it holds further discussions with the FDA about the risk, the Associated Press reported.

Last September, the FDA approved Palladone for sale in the United States. However, data from a new study by Purdue Pharma indicates that taking the drug together with alcohol affects the drug capsule's slow-release function. This results in rapid movement of the drug into the bloodstream, which can lead to a potentially fatal overdose.

Labeling on Palladone does warn people not to drink alcohol when they're taking the painkiller, and there have not been any reports of serious reactions among users of Palladone, the FDA said.

About 11,500 patients have taken the drug, said Purdue Pharma, which has asked wholesalers and drug stores to return unsold Palladone capsules.

The company, which also makes the controversial long-acting painkiller Oxycontin, had limited initial Palladone sales to doctors experienced in prescribing opioid painkillers. The drug is for moderate to severe pain, caused by cancer or other conditions, in patients who need round-the-clock relief.

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Experts Pan U.S. Web Site for Parents, Teens

A U.S. government Web site for parents and teenagers contains inaccurate and misleading information about condoms, sexual orientation, the dangers of oral sex and single-parent households, say a team of medical experts who reviewed the site.

The team of three physicians and a child psychologist concluded that the incorrect information on the Bush administration's 4Parents.gov Web site may prompt riskier teen behavior or alienate some families, the Washington Post reported.

The Web site analysis was solicited by Rep. Henry A. Waxman (D-Calif.) who sent a to Health and Human Services Secretary Mike Leavitt saying: "A federally funded website should present the facts as they are, not as you might wish them to be. It is wrong -- and ultimately self-defeating -- to sacrifice scientific accuracy in an effort to frighten teens and their parents."

One of the experts, Temple University child psychologist Laurence Steinberg, told the Post he was disturbed by the site's negative messages about single parents and gays and concerned that the site had virtually no information on the dangers of teen alcohol consumption.

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Groups Fight Over Children's Food Advertising

Food manufacturers and consumer activists are battling over whether voluntary industry standards or government regulation is the best way to deal with concerns about food advertising targeted at children.

The two sides traded barbs the day before a two-day workshop examining the effectiveness of self-regulation efforts by the television industry. The workshop is sponsored by the U.S. Department of Health and Human Services and the Federal Trade Commission, the Washington Post reported.

The consumer group The Center for Science in the Public Interest asked the Food and Drug Administration to require health warnings on soft drinks, the biggest source of calories in the diet of Americans, the group said.

However, large food manufacturers countered that it's up to their industry to tighten voluntary advertising standards in order to address health concerns associated with food marketing to children.

The Grocery Manufacturers Association said companies shouldn't be permitted to pay to have their products displayed in children's television shows, the Post reported.

Cancer Doesn't Have to Cost You Your Fertility

Cancer treatment advances are giving younger patients the chance to preserve their fertility, enabling them to start families at a future date, a new review states.

According to a report in the July/August issue of CA: A Cancer Journal for Clinicians, physicians can offer an enhanced chance of protecting fertility without negatively affecting the outcome of cancer treatment or survival.

"This is very good news because it shows that the number of people who are being treated with cancer and living, and are able to be concerned about fertility, is increasing," said Dr. Jay Brooks, chairman of hematology/oncology at the Ochsner Clinic Foundation in Baton Rouge, La. "We didn't have this problem years ago because people didn't live."

According to the review, the last two decades have seen enormous progress in the five-year survival rates for most cancers.

Simultaneous with this progress has been an improved ability to preserve fertility without affecting the success of the treatment.

Both radiation and chemotherapy, staples of cancer treatment, can affect men's and women's ability to have children. In addition, surgery for testicular or ovarian cancer can diminish or eliminate the possibility of producing a baby.

For this review, the authors looked at the most common cancers affecting young adults as well as some less common cancers that directly affect the reproductive organs. The cancers included breast, cervical, endometrial, ovarian, and testicular tumors, as well as leukemia and lymphoma.

"The outlook is much more hopeful because technologies have improved and we have begun to understand cancer better so we can offer more conservative therapies," said Dr. Carolyn Runowicz, one of the review's authors. She is president-elect of the American Cancer Society and director of the Neag Comprehensive Cancer Center at the University of Connecticut Health Center in Farmington.

Today, a young woman with ovarian cancer may be able to keep her uterus and to retain one ovary -- or at least tissue from one ovary.

Older strategies of keeping ovaries in a quiescent phase or freezing oocytes (eggs) have had only limited success. Newer, more promising strategies include freezing strips of ovarian tissue, then reimplanting them after the cancer treatment is completed.

In June, a 28-year-old Israeli woman whose ovaries had been destroyed by high-dose chemotherapy gave birth to a healthy baby girl after doctors transplanted some of her own frozen ovarian tissue. This was the first time such a technique was successful.

"To me, this is very exciting," Runowicz said. "It's still obviously investigational but it shows a light at the end of the tunnel."

Cryopreservation (freezing) of semen is recommended for men with testicular cancer who wish to have children in the future. Although the procedure and technology are relatively simple, few men take advantage of this option, the review noted.

"Many times people who are diagnosed with cancer want to get treated yesterday," Brooks said. "The cancer is so pressing they don't think about the fertility issues."

Later, however, when the cancer treatment is over, many men (and women) regain past priorities. By that time, it can be too late.

"Cryopreservation of sperm has been available for a while but when people hear the word cancer, saving sperm seems like an unnecessary delay," Runowicz said. "Then, all of sudden when you're better, they say, 'Gee whiz, I should have done that.'"

"One message for men is cancer doesn't happen like an emergency and is not an emergency in most cases," Runowicz continued. "They have time to explore and bring up that subject [sperm preservation] if the treating physician does not."

More information

To learn more about infertility, visit the American Society for Reproductive Medicine.

 
 
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