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Recent News and Articles on the Keywords: you have + keyword you + search  Related to the article below (Last Update: 5/13/2008)


eFluxMedia
Posted by: Rob Hof on May 12
BusinessWeek -
What you notice immediately when searching on something, whether it?s in the form of a question or the usual keyword combinations, is that Powerset?s engine ...
Powerset Unveils Test Version of Google-killer ABC News
Powerset Launches Showcase For User Search Experience Washington Post
Powerset shows semantic search solution ZDNet Blogs
TechNewsWorld - RedOrbit
all 141 news articles »  GOOG - MSFT

bit-tech.net
Image-based search with TinEye
bit-tech.net, UK - 25 minutes ago
Wouldn't it be handy if you could just upload the closest equivalent image you have and let the power of the web do its magic thing? ...
Relevancy is What Matters in SEM
Promotion World (press release), CA - May 12, 2008
Keywords are just the tip of the search query iceberg: Advertise the keyword ?bicycle? on broad match and you could very well serve for searches on the ...
SEO and Meta Tags
Promotion World (press release), CA -
So, with present algorithms which are really smart and intelligent include only those relevant keywords you want to target and make sure that these are ...
Making the most of being a certified disadvantaged firm
Los Angeles Times, CA - May 12, 2008
Answer: There are professionals who do nothing but "optimize" websites for prominent search engine placement. If you can't afford one, here are some tips ...
SherpaBlog: 5 Ways to Improve Blog Results Today: How to Engage ...
MarketingSherpa.com (subscription), RI - May 11, 2008
While it?s fine to see how many visitors you get, the most useful report is actually the keyword analysis report. There, you?ll find a list of the terms ...
Good Old-Fashioned Link Building
ClickZ News, NY - May 11, 2008
You search for potential linking partners, approach them and ask for a link (and often you provide one in return). I refer to this approach as a "direct" ...

R744.com
? R744.com has evolved...
R744.com, Belgium - 25 minutes ago
Members section: After your FREE registration as an R744.com Member, you have full access to all additional features offered on the website, ...
Search Engine News, An In-Depth Look At Google's Tools & The ...
Search Engine Land, CT - May 9, 2008
This week, there was an update of the Keyword Tool. "You may have noticed that we made a change the traffic estimates data in the Keyword Tool. ...GOOG
SmartFinds Internet Marketing Improves Web Site Results for Top ...
PR Web (press release), WA -
You can learn more about SmartFinds at SmartfindsMarketing.com. Contact: Doug Menzer, PO Box 370, Bloomfield Hills, MI 48303, (866) 501-5758.PINK:IMIZ
Source: Google News

[CITATION] Inc
C Technology

Statistical analysis of cointegration vectors
S Johansen - Journal of Economic Dynamics and Control, 1988 - ideas.repec.org
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this document is restricted, you may want ... y:1988:i:2-3:p:231-254 Keywords: ...

Measuring the efficiency of decision making units -
A Charnes, WW Cooper, E Rhodes - European Journal of Operational Research, 1978 - ideas.repec.org
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this document is restricted, you may want ... v:3:y:1979:i:4:p:339-338 Keywords: ...

The Brazilian Cerrado Vegetation and Threats to its Biodiversity -
JA RATTER, JF RIBEIRO, S BRIDGEWATER - Annals of Botany, 1997 - Annals Botany Co
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The relationship between return and market value of common stocks
RW Banz - Journal of Financial Economics, 1981 - ideas.repec.org
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on the Munich Personal RePEc Archive (MPRA) if you do not have access to an ...

In search of a useful theory of innovation -
RR Nelson, SG Winter - Research Policy, 1977 - ideas.repec.org
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Pulmonary complications of bone marrow transplantation -
AO Soubani, KB Miller, PM Hassoun - Chest - Am Coll Chest Phys
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[PDF] Encyclopaedia Britannica -
E Britannica? - 1967 - 129.66.12.115
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Staggered Prices in a Utility-Maximizing Framework
G Calvo - Journal of Monetary Economics, 1983 - ideas.repec.org
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Management Ownership and Market Valuation: An Empirical Analysis
R Morck, A Shleifer, R Vishny - Journal of Financial Economics, 1988 - ideas.repec.org
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Source: Google Scholar

Keeping At Risk Cells From Developing Cancer

 
Researchers at Johns Hopkins have discovered that cancers arising from epigenetic changes - in this case the inappropriate activation of a normally silent gene - develop by becoming addicted to certain growth factors. Reporting online in next week's Early Edition of the Proceedings of the National Academies of Sciences, the team shows that blocking this "addiction" can greatly prevent cancer growth.

"If this is translatable to people, it could be really exciting," says Andrew Feinberg, M.D., professor of medicine, oncology and molecular biology and genetics and director of the Epigenetics Center at Hopkins. "It means we might be able to do something about at-risk cells before cancer develops, and treat these cells biochemically and specifically, rather than using current drugs that are nonspecific and kill everything in their path."

The gene for growth factor IGF-II (insulin-like growth factor two) is one of several in the human genome that is controlled by imprinting - where one of the two copies of the gene is turned off, depending on which parent it came from. Normally, the IGF-II gene from your father is turned on and the one from your mother is turned off. Loss of this imprinting causes the activation of the maternal copy, leading to activation of both copies of the IGF-II gene, which has been associated with a fivefold increased frequency of intestinal tumors in people.
The Hopkins team tested mouse cells with imprinting intact, which have only one copy of IGF-II activated, and compared them to cells that had lost imprinting and have both copies of IGF-II activated. They found that normally imprinted cells respond to normal doses of growth factor and recover within 90 minutes. However, cells that had lost imprinting were activated by the smallest doses and continued to stay activated for more than 120 minutes.

"It's like they were on a hair trigger, which was totally counterintuitive to what we might have predicted," says Andre Levchenko, Ph.D., an assistant professor of biomedical engineering at Hopkins and co-director of the study. "You would expect in cells that have lost imprinting, and therefore have twice the amount of gene product, that it would take higher doses to activate the cell. In fact, the cell becomes hypersensitized while having too much IGF-II around."

The researchers then wondered if blocking the cells' response to IGF-II could block cancer growth in animals. Mice that develop colon cancer were given a drug that specifically blocks a cell's ability to respond to IGF-II. These mice developed 70 percent fewer precancerous lesions than mice without treatment.

"Finding the molecular mechanism behind cancer development allowed us to use a specific drug to actually take care of these risky cells before the animal developed cancer," says Feinberg. "It's making us think about cancer prevention in a whole new way."

The research was funded by the National Institutes of Health and the Swedish Cancer Research Foundation.

Authors on the paper are Atsushi Kaneda, Chiaochun Wang, Raymond Cheong, Winston Timp, Patrick Onyango, Bo Wen, Christine Iacobuzio-Donahue, Andre Levchenko and Feinberg of Hopkins; Rolf Ohlsson of Uppsala University in Uppsala, Sweden; Rita Andraos and Mark Pearson of Novartis Institute of Biomedical Research in Basel, Switzerland; and Alexei Sharov, Dan Longo and Minoru Ko of the National Institute on Aging in Baltimore, Md.

Johns Hopkins Medicine
901 S. Bond St., Ste 550
Baltimore, MD 21231
United States
http://www.hopkinsmedicine.org
 
 
 
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