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Recent News and Articles on the Keywords: kidney cancer + breaking developments + cancer  Related to the article below (Last Update: 5/5/2008)

Major League Baseball Hall of Famer Don Sutton Helps Kidney Cancer ...
FOXBusiness -
Stay In The Game is an educational program that empowers people affected by kidney cancer to seek support, resources and information that can help them ...ONXX - OTC:CMTX
Tailored drug therapy for kidney cancer
Toronto Star,  Canada - May 1, 2008
HIS RESEARCH: Patients with kidney cancer all get the same drugs, but not everyone responds the same. Finelli and his colleagues want to understand why ...

Daily Mail
Little friend of a lifetime - the extroadinary and poignant bond ...
Daily Mail, UK -
She was diagnosed with Wilms' tumours - a kidney cancer found mainly in under-fives. The cancer was very advanced and had already spread from Molly's right ...
Better system could cut cancer deaths
ic Wales, United Kingdom -
Cancer was found in one kidney and, shortly after, one kidney was successfully removed. Soon after this my father complained of a lump on his left side. ...
Grandad's plea: Ignoring telltale signs can be lethal
Blackpool Gazette, UK -
By Emma Harris A FYLDE coast grandfather is urging others to be aware and not be shy to see their doctor after he was diagnosed with kidney cancer. ...
Targeted Combination Therapy Triggers Cell Death in Mouse Models ...
Science Daily (press release) - Apr 29, 2008
The combination also prolonged overall survival in mice with kidney cancer. Bortezomib blocks the activity of the proteasome, an enzyme complex which ...

BBC News
Man fights for kidney cancer drug
BBC News, UK - Apr 23, 2008
A kidney cancer patient has called for an expensive drug to be made available on the NHS in Norfolk. David Blackett, 65, of Bunwell, is using his retirement ...
Kidney cancer may be linked to multiple myeloma
Reuters - Apr 21, 2008
... the H. Lee Moffitt Cancer and Research Institute in Tampa, Florida, noted in comments to Reuters Health. Renal cell carcinoma begins in the kidney cells ...
Once Again, Holding Out Hope For A Kidney
WCCO, MN -
The Epstein Barr virus that lay dormant in the transplanted kidney resurfaced, causing cancer. Sean Yang's parents were faced with an unimaginable decision ...
Charge $50k for transplants, specialist says
ABC Online, Australia -
They are probably also more likely to suffer from lifestyle diseases later in life and may end up needing a kidney transplant themselves at some stage in ...
Source: Google News

Progress in the development of immunotherapy for the treatment of patients with cancer -
SA Rosenberg - Journal of Internal Medicine, 2001 - Blackwell Synergy
... of the melanoma resulted in the breaking of tolerance ... of 104 patients with metastatic
kidney cancer who received ... vitiligo compared with the development of this ...

THE ROLE OF THE FHIT/FRA3B LOCUS IN CANCER -
K Huebner, PN Garrison, LD Barnes, CM Croce - Annual Reviews in Genetics, 1998 - Annual Reviews
... The position of FRA3B is indistinguishable from a familial kidney cancer-associated
3p14.2 translocation break, t(3;8)(p14.2;q24) (10, 24). ...

Tolerance and Cancer: Mechanisms of Tumor Evasion and Strategies for Breaking Tolerance -
MY Mapara, M Sykes - Journal of Clinical Oncology, 2004 - jcojournal.org
... in a new window], Fig 2. Strategies for breaking tolerance. ... a variety of solid tumors
(colon cancer, prostate cancer, melanoma, renal cell carcinoma [RCC ...

Genetic susceptibility to non-polyposis colorectal cancer -
HT Lynch, A de la Chapelle - British Medical Journal, 1999 - jmg.bmj.com
... to keep abreast of these fast breaking events ... ovarian, gastric biliary tract,
uroepithelial, kidney, and central ... The cumulative cancer incidences by the age of ...

NormalFHIT transcripts in renal cell cancer- and lung cancer-derived cell lines, including a cell … -
A van den Berg, TG Draaijers, K Kok, T Timmer, AY … - Genes Chromosomes and Cancer, 1997 - doi.wiley.com
... border at about 75 kb?100 kb distal to the break- point of the constitutive
t(3;8) occurring in a family with hereditary renal cell cancer (Cohen et ...

Tubulo-interstitial lesions mediate renal damage in adriamycin glomerulopathy -
T Bertani, F Cutillo, C Zoja, M Broggini, G … - Kidney Int, 1986 - nature.com
... which was determined by tubular obstruction and breaking of tubular ... Cancer Res
32:1177?1183, 1972; Giroux L, Smeesters C ... Kidney Int 24:152?159, 1983; Ryan GB ...

Antiangiogenic Therapy: A Universal Chemosensitization Strategy for Cancer? -
RS Kerbel - Science, 2006 - sciencemag.org
... SU11248 or BAY-43-9006 for kidney cancer (Table 1 ... shown success in early-stage breast
cancer as adjuvant ... an antiangiogenic drug during the break periods between ...

Breaking down the barriers to cancer immunotherapy -
E Pur?, JP Allison, RD Schreiber - Nature Immunology, 2005 - nature.com
... Breaking down the barriers to cancer immunotherapy. ... signaling will facilitate the
development of more ... of patients with melanoma and renal cancer treated with ...

Renal cancer: cytogenetic and molecular genetic aspects -
AM Meloni-Ehrig - American Journal of Medical Genetics (Semin. Med. Genet.), 2002 - doi.wiley.com
... Decker et al., 1988], the hereditary renal cancer associated 1 ... adjacent to the
3p14.2 break- point [Boldog ... predispos- ing factors in the development of about 75 ...

Dendritic-cell-based therapeutic vaccination against cancer -
FO Nestle, A Farkas, C Conrad - Current Opinion in Immunology, 2005 - Elsevier
... aspects for the further development of DC ... and J. Allison, Cancer immunotherapy: breaking
the barriers ... responses in metastatic renal cancer patients vaccinated ...

Source: Google Scholar

Late Breaking Developments In Transitional Kidney Cancer
UroToday.com - Two late breaking development papers were presented in the field of renal cancer.

"Surgical morbidity associated with administration of targeted molecular therapies prior to cytoreductive nephrectomy for metastatic renal cell carcinoma"

Dr. Vitaly Marguilis presented the concept of cytoreductive nephrectomy (CRN) as defined with INF-alpha to CRN prior to targeted therapies. One benefit is that patients who are benefiting from targeted therapy go on to surgery and those who are not would likely not benefit from surgery. Patients studied underwent CRN prior to treatment with bevacizumab, sorafenib, or sunitinib on clinical trials. These patients were compared to traditional CRN patients receiving neoadjuvant systemic therapy. Surgical parameters and complication rates were the same. In summary, bevacizumab stopped 30 days prior to surgery and TKI inhibitors stopped 1 day prior to surgery did not lead to increased complications.

"Metastatic renal cell carcinoma with venous extension undergoing radical nephrectomy and thrombectomy: prognostic implications"
Dr. Juan Martinez-Salamanca analyzed the impact of presence of metastasis at the time of diagnosis in a group of patients treated by surgery. They were stratified by sites of metastasis and evaluated for survival. A total of 671 patients from 8 international institutions were studied. Clinical and pathologic variables were included. The median followup was 43.5 months. There were 510 stage M0 patients and 141 stage M1 patients of whom 60 had lung metastases only and the remaining 81 had numerous sites of metastasis. The 5 year M0 survival was 52% compared to 18% for several mets and 23% for lung-only mets. There was no difference between the lung-only mets and several mets groups. The conclusion is that the decision for surgery should be based upon the presence of mets, not the number of locations. However, the nodal staging was not included in the analysis and could significantly influence the outcome. Also, the selection criteria for surgery were not defined.

Presented at the 8th Annual Meeting of the Society of Urologic Oncology (SUO) - November 29 - December 1, 2007. Natcher Conference Center, National Institutes of Health - Bethesda, Maryland.

Reported by UroToday.com Contributing Editor Christopher P. Evans, MD

UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice.

To access the latest urology news releases from UroToday, go to: www.urotoday.com

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Copyright © 2007 - UroToday
Reproduced for Medical News Today with permission of UroToday.
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