Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California
blank

 

Recent News and Articles on the Keywords: scientists discover + new role + microrna  Related to the article below (Last Update: 5/13/2008)

Rosetta Genomics Announces Expansion of its MicroRNA Intellectual ...
PR Newswire (press release), NY - Apr 28, 2008
Rockefeller scientists established that DNA is the chemical basis of heredity, discovered blood groups, showed that viruses can cause cancer, ...ROSG
Source: Google News

[PDF] MicroRNA: past and present -
Y Wang, HM Stricker, D Gou, L Liu - Front Biosci, 2007 - bioscience.org
... Using these tools, scientists are able to discover novel functions ... However, a new
area of investigation is concentrating on the role of microRNAs (miRNAs ...

Studies Define Role of microRNA in Cancer -
K Hede - jnci, 2005 - jnci.oxfordjournals.org
... the more than 200 miRNA sequences discovered in the ... University in Hanover, NH, the
first scientist to isolate ... 119K): [in this window] [in a new window], Scott ...

Commercial potential of RNAi -
KK Jain - Molecular BioSystems, 2006 - rsc.org
... gene therapy and open up new markets for ... RNAi reagents and technologies are scientists
in academia ... pharmaceutical companies are using RNAi in drug discovery. ...

microRNA: A Revolution in Gene Expression
AA Discovery, WRG Awry - Sea, 2004 - jyi.org
... or, they could stop mRNA from translating its information into new proteins ... no surprise
that it took nearly 30 years for scientists to discover this unusual ...

God and the New Foodstuffs
T Popp - Science & Spirit, 2006 - Heldref Publications
... widely considered a useless evolutionary leftover until scientists recently discovered
the strands ... ?This paper suggests there is a new mechanism to ...

link to a new window web book: BIOLOGICAL ROLE OF microRNAs (miRNA) IN ANIMAL CELLS, DEVELOPMENT AND …
M MR?Z, M Mr?z - 2007 - muni.cz
... Scientists begin to unterstand the importance of the ... of eukaryotic microRNAs has
to be discovered and identification ... that microRNAs could disclose new ways for ...
-

New tracheobronchial stent system launched by Alveolus, Inc.
A Options, TOC Latest - Expert Review of Molecular Diagnostics, 2007 - ingentaconnect.com
... that miRNAs also play an important role in cancer. ... their findings will help other
scientists discover causes and ... Col- lege commented, ?Our new findings mean ...

Identifying targets for drug discovery using bioinformatics -
YPP Chen, F Chen - Expert Opinion on Therapeutic Targets, 2008 - Expert Opinion
... These tools help scientists to make better experiments and ... New York: Springer; 2005. ...
Discovery of microRNA-mRNA modules via population-based probabilistic ...
-

Identifying targets for drug discovery using bioinformatics -
YP Phoebe Chen, F Chen - Expert Opin. Ther. Targets, 2008 - Expert Opinion
... These tools help scientists to make better experiments and ... New York: Springer; 2005. ...
Discovery of microRNA-mRNA modules via population-based probabilistic ...
-

Tracing microRNA patterns in mice
N Biotechnology, N Methods, N Conferences, D … - Nature Genetics, 2004 - nature.com
... Since the discovery of the let-7 and lin-4 miRNAs in ... Hoxb8 transcript 3, 9 . Although
these observations might bring new players into ... Postdoctoral Scientist. ...
-

Source: Google Scholar

Scientists discover new role for miRNA in leukemia

COLUMBUS, Ohio – Scientists here have found that mini-molecules called micro-RNA may play a critical role in the progression of chronic myeloid leukemia (CML) from its more treatable chronic phase to a life-threatening phase, called blast crisis.

Furthermore, they discovered an entirely new function for these molecules. The researchers show that microRNAs can sometimes directly control a protein’s function – not just whether or not the protein is made by the cell, as has been believed.

The study, using cells from CML patients in blast crisis, suggests that certain progenitor white blood cells are kept from maturing when levels of one microRNA, called miR-328, fall abnormally low. Immature white cells then build up in the blood and bone marrow, a telltale sign that the patient has entered the therapy-resistant blast-crisis phase.

The findings are being presented at the 2007 annual meeting of the American Society of Hematology (ASH), Dec. 8-11 in Atlanta.

“If verified, our study suggests that altering microRNA levels might represent a potentially new therapeutic strategy for CML patients who do not benefit from effective targeted agents such as imatinib (Gleevec) and dasatinib (Sprycel),” says principal investigator Danilo Perrotti, assistant professor of molecular virology, immunology and medical genetics and a researcher with the Ohio State University Comprehensive Cancer Center.

“The findings also reveal a new function for microRNAs, which should further our understanding of their role in cancer development and progression, and in normal cells.”

Researchers have known for some time that microRNAs bind to molecules called messenger RNA, which are part of the cell’s protein-making machinery, and in this way help regulate the types and amount of proteins made by cells.

But this study shows for the first time that the microRNA molecules sometimes bind directly with proteins themselves and affect their function.

In this case, a microRNA called miR-328 binds with a protein that, in blast phase CML, prevents immature blood cells from maturing. “We believe that miR-328 acts as a decoy molecule that normally ties up the protein, which enables the white blood cells to mature as they should,” Perrotti says.

During progression from chronic-phase to blast-crisis CML, however, the level of miR-328 falls, allowing the protein to be extremely active. This keeps the progenitor white blood cells from maturing, thus favoring blast-crisis conditions.

“These findings are important because they help us understand the biology of blast-crisis CML, and they may help unravel novel pathways responsible for the initiation and progression of leukemia generally,” Perrotti says.

###

Funding from the National Cancer Institute, the Department of Defense and the Leukemia and Lymphoma Society supported this research. Perrotti is a Scholar of the Leukemia and Lymphoma Society.
 
 
 
Google
Web www.iconocast.com

Search inside Iconocast for the keyword you have in mind.

Iconocast has collected more than 50,000 articles and press releases on health and science.

These are current and most up to date press releases on the subject you are searching.

We collect current health and science press releases daily from more than 5000 research and health institutes. Here is an example : The elderberry way to perfect skin

We believe if you do search inside Iconocast, you will get better results than searching the web alone.

 
 
Continue News With: News2 ; News3 ; News4 ; News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services.

 

Iconocast Home Page

Contact Iconocast

© 2003-07. ICONOCAST is a trademark of iconocast.com.