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Recent News and Articles on the Keywords: cancer institute + research discovery + chronic  Related to the article below (Last Update: 5/5/2008)

Should you take Aspirin to prevent cancer?
CTV.ca, Canada -
A new National Cancer Institute study of over 125000 women between the ages of 51 and 72 has found that taking Aspirin appears to lower the risk of ...
Array BioPharma Reports Financial Results for the Third Quarter of ...
Genetic Engineering News (press release), NY - 59 minutes ago
Continued research with Celgene Corporation on four drug discovery programs in cancer or inflammation. -- Continued research with Genentech on three drug ...ARRY
Delays in starting radiotherapy can increase risk of cancer recurrence
Lifegen.de (Abonnement), Germany -
In head and neck cancer, tackling chronic waiting lists could deliver an absolute increase in local control of between 5 and 10 % simply by reducing ...

Johns Hopkins Gazette
Two From JHU Elected to National Academy of Sciences
Johns Hopkins Gazette, MD -
He currently is studying the role of HIF-1 in cancer, ischemia and chronic lung disease, the most common causes of mortality in the US population. ...
Primary Driver Of Stomach Cancer Development Identified
Science Daily (press release) - Apr 22, 2008
ScienceDaily (Apr. 22, 2008) ? In a discovery that could lead to the development of new treatments for gastric cancer, scientists at the Melbourne Branch of ...
HLA-Omics and Cancer Biomarkers: Emerging Tools and Technologies ...
RedOrbit, TX - May 1, 2008
National Cancer Institute surveillance epidemiology and end results. National Cancer Institute. http://seer.cancer.gov. Accessed January 2, 2008. 4. ...OTC:CTHP
Discovery Offers New Avenues To Understanding An Aggressive Form ...
Science Daily (press release) - Apr 15, 2008
The researchers also found that loss of the same gene accompanied the transformation of chronic myelogenous leukemias (CMLs) to a life-threatening acute ...
PNNL hunts key to cancer detection
Mid Columbia Tri City Herald, WA - Apr 23, 2008
Smith wants to develop technology to find blood proteins that reveal early signs of chronic liver disease. The goal is to be able to diagnose a condition ...
UCSD, TargeGen team-up on blood disease treatment
San Diego Union Tribune, United States - Apr 7, 2008
In the research documented in the Cancer Cell article, her team put human stem cells engineered to have the mutant gene into mice models to see if the ...
In Lab Study, Researchers Find Molecule That Disrupts Ewing's ...
Science Daily (press release) - Apr 14, 2008
Using a library of small molecules loaned to Georgetown from the National Cancer Institute, the team of investigators tested 3000 compounds to see if any ...
Source: Google News

Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic … -
A Rosenwald, AA Alizadeh, G Widhopf, R Simon, RE … - Journal of Experimental Medicine, 2001 - Rockefeller Univ Press
... In this gene discovery phase, we assigned the minimally mutated CLL ... Research at Stanford
was supported by grants from the National Cancer Institute to D ...

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive … -
N Immunology, N Conferences, D Discovery - Nature Medicine, 1997 - palgrave-journals.com
... should be addressed to JED Department of Genetics, Research Institute, Hospital
for ... Cancer Inst. ... and peripheral blood from CML patients in chronic phase while ...

Mouse model of X?linked chronic granulomatous disease, an inherited defect in phagocyte superoxide … -
JD Pollock, DA Williams, MAC Gifford, LL Li, X Du, … - Nature Genetics, 1995 - nature.com
... B Wells Center for Pediatric Research, Departments of ... 2 Howard Hughes Medical Institute,
Indiana University ... and the Dana Farber Cancer Institute, Department of ...

[PDF] Rules of evidencefor cancer molecular-marker discovery and validation -
DF Ransohoff - NATURE REVIEWS| CANCER, 2004 - cap.org
... MODELS , such as those that are used in discovery-based research, show apparent
discrimination (for example, between persons with and without cancer,or with ...
-

[PDF] Bias as a threat to the validity of cancer molecular-marker research -
DF Ransohoff - Nat Rev Cancer, 2005 - dmrocke.ucdavis.edu
... serum proteomics can diagnose ovarian cancer (or any cancer), but, more importantly,
about the process through which discovery-based research is designed ...

Restoring function in exhausted CD8 T cells during chronic viral infection -
DL Barber, EJ Wherry, D Masopust, B Zhu, JP … - Nature, 2006 - nature.com
... EJW and DM were supported by the Cancer Research Institute. ... JN & Ahmed, R.
Antigen-independent memory CD8 T cells do not develop during chronic viral infection ...

Evolution of Anticancer Drug Discovery and the Role of Cell-Based Screening -
FM Balis - jnci, 2002 - jnci.oxfordjournals.org
... Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute,
Bethesda, MD. ... by exploiting the differences between cancer cells and ...

[PDF] Use of isogenic human cancer cells for high-throughput screening and drug discovery -
CJ Torrance, V Agrawal, B Vogelstein, KW Kinzler - Nat Biotechnol, 2001 - jade.botany.utoronto.ca
... of this approach through the discovery of a novel ... Program at the National Cancer
Institute (NCI) for ... the National Foundation for Cancer Research, and National ...
-

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling -
AA Alizadeh, MB Eisen, RE Davis, C Ma, IS Lossos, … - Nature, 2000 - nature.com
... Bethesda, Maryland 20892, USA; Research Genetics, Huntsville ... Clinical Sciences, National
Cancer Institute, National Institutes ... category, each cancer patient has ...

Methylation of RUNX 3 in various types of human cancers and premalignant stages of gastric carcinoma -
TY Kim, HJ Lee, KS Hwang, M Lee, JW Kim, YJ Bang, … - Laboratory Investigation, 2004 - nature.com
... Epigenetics, Seoul, South Korea; 2 Cancer Research Institute, Seoul, South ... methylation
is not restricted to gastric cancer. ... found in 8.1% of chronic gastritis (n ...

Source: Google Scholar

OHSU Cancer Institute research discovery opens new window to understanding chronic myeloid leukemia

ATLANTA – Oregon Health & Science University Cancer Institute researchers have opened a new window into the roots of chronic myeloid leukemia (CML).

“We are looking under the surface of CML to understand better where the cancer is coming from. We have discovered abnormal cells in the early stem cell population in some CML patients, which don’t belong to the CML clone. These are abnormal cells that are not part of the CML clone,” said Thomas Bumm, M.D., OHSU Cancer Institute member.

This research will be presented at the American Society of Hematology annual meeting in Atlanta on Sunday, Dec. 9, at 4:30 p.m.

Bumm was looking into Philadelphia Chromosome-negative stem cells – which he and others had thought would look like normal, healthy cells, and have normal chromosomes. (It has been known that the driving force of CML is the Philadelphia Chromosome-positive cancer cells.)

“But no, these chromosome negative cells are not normal looking. We are seeing that there are other abnormal cells in the early stem cell population in the bone marrow of some CML patients that are Philadelphia Chromosome-negative. They have abnormalities such as the deletion of chromosome 7 or a duplication of chromosome 8,” explained Bumm, a fellow in hematology/medical oncology, OHSU School of Medicine.

It is not known why patients with CML have these abnormal cells and to what extent. These newly discovered abnormal cells are also seen in other cancers such as myelodysplastic syndrome.

“We are not yet sure about the extent of this problem. We do hope though that our studies into the stem cell compartment of CML patients might help to find new targets for CML therapy to cure this cancer,” Bumm said.

Chronic myelogenous leukemia is a form of blood cancer characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood.

The next step, although costly, will be to analyze more leukemia patients as well as healthy bone marrow samples to continue to look for these new abnormalities.

###

Working with Bumm on this research is Amy E. Hanlon Newell, Ph.D., senior research associate in molecular and medical genetics, OHSU School of Medicine; and Jutta Deininger M.D., senior research assistant, hematology/medical oncology, OHSU School of Medicine and an OHSU Cancer Institute member.

The study was performed in the laboratory of Michael Deininger, M.D., Ph.D., associate professor of medicine, hematology/medical oncology, OHSU School of Medicine.

The research is abstract #36

The OHSU Cancer Institute is the only National Cancer Institute-designated center between Sacramento and Seattle. It comprises some 120 clinical researchers, basic scientists and population scientists who work together to translate scientific discoveries into longer and better lives for Oregon's cancer patients. In the lab, basic scientists examine cancer cells and normal cells to uncover molecular abnormalities that cause the disease. This basic science informs more than 200 clinical trials conducted at the OHSU Cancer Institute.
 
 
 
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