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Recent News and Articles on the Keywords: dopamine neurons + the birth + models  Related to the article below (Last Update: 5/13/2008)

Brain maturation may be defense in teen's murder trial
Ventura County Star, CA - May 4, 2008
People are born with more brain neurons that share information with each other than they need. As the brain matures, it weeds out connections that aren't ...
Source: Google News

[PDF] EXPERIMENTAL MODELS OF PARKINSON'S DISEASE -
MF Beal - Nature Reviews Neuroscience, 2001 - nature.com
... neurons at birth with selective and gradual loss of dopamine neurons commencing
in ... Second, the model should have easily detectable motor deficits ...
-

Selective vulnerability of late-generated dopaminergic neurons of the substantia nigra in weaver … -
SA Bayer, KV Wills, LC Triarhou, T Verina, JD … - Proceedings of the National Academy of Sciences of the …, 1995 - JSTOR
... the only naturally occurring animal model of genetically ... controls (+/+) we determined
that at birth wv/wv ... have normal numbers of dopaminergic neurons in their ...

THE GDNF FAMILY: SIGNALLING, BIOLOGICAL FUNCTIONS AND THERAPEUTIC VALUE -
MS Airaksinen, M Saarma - Nature Reviews Neuroscience, 2002 - cns.nyu.edu
... Because GDNF protects dopamine neurons in animal models of ... can therefore be used
to identify responsive neurons. ... Gross phenotype Lethal at birth 32 Lethal at ...

[PDF] … the bacteriotoxin lipopolysaccharide leads to long-term losses of dopamine neurons in offspring: a … -
PM Carvey, Q Chang, JW Lipton, Z Ling - Front Biosci, 2003 - bioscience.org
... window in rats, leads to the birth of animals with fewer than normal dopamine (DA)
neurons ... The DA neuron loss is accompanied by reductions in striatal DA ...

A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b -
MP Smidt, CHJ Asbreuk, JJ Cox, H Chen, RL Johnson, … - Nature Neuroscience, 2000 - nature.com
... were gradually lost before birth 13 . ... higly restricted brain expression in mesencephalic
dopaminergic neurons. ... Dopamine neuron agenesis in Nurr1-deficient mice ...

Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons -
P van den Munckhof, KC Luk, L Ste-Marie, J … - Development, 2003 - dev.biologists.org
... Most sensitive are the vSNc neurons that are severely depleted by birth in ak ... Striatal
dopamine deficiency SN dopaminergic neurons project primarily to the ...

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's … -
MS Goldberg, PT Lansbury Jr - Nature Cell Biology, 2000 - nature.com
... is that the substantia nigra dopaminergic neurons containing Lewy ... and biochemical
criteria, than neighbouring neurons 28, 29 ... at the time of birth, a transgenic ...

… Neural Stem Cells Regulate the Function of Nigral Dopaminergic Neurons and Prevent Their … -
P ?kerud, PC Holm, G Castelo-Branco, K Sousa, FJ … - Molecular and Cellular Neuroscience, 2002 - Elsevier
... developmental stages, for ex- ample after birth in the ... by 68% of the loss of
dopaminergic neurons and by ... behavioral abnormalities in a rodent model of Parkinson ...

… of Cell Cycle Markers in Models of Induced Programmed Cell Death in Dopamine Neurons of the Rat … -
BF El-Khodor, T Frances Oo, N Kholodilov, RE Burke - Experimental Neurology, 2003 - Elsevier
... vivo demonstration that neuronal apoptosis in dopamine neurons of the ... Animal Models
Timed pregnant Sprague-Dawley rats (14 ... day, and the day of birth was defined ...

Birth insult interacts with stress at adulthood to alter dopaminergic function in animal models: … -
P Boksa, BF El-Khodor - Neuroscience and Biobehavioral Reviews, 2003 - Elsevier
... a trophic factor for dopaminergic neurons, may be ... increased in the corresponding
dopaminergic terminal region ... as distinct animal models of birth hypoxia; gender ...

Source: Google Scholar

The birth and death of dopamine neurons: A new model for neurodegeneration

The gradual loss of dopamine neurons is a hallmark of many neurodegenerative diseases - Parkinson’s Disease chief among them. Stem cell biology and regenerative medicine offer novel therapies for the restoration of dopamine neurons. This week in the online open-access journal PLoS Biology Dr. Raja Kittappa, Dr. Wendy Chang, Dr. Rajeshwar Awatramani, and Dr. Ronald McKay show that the transcription factor FOXA2 plays a central role in the birth and death of dopamine neurons in the midbrain. By defining precursors of dopamine neurons in the ventral midbrain, Kittappa et. al. have discovered that dopamine neurons are derived from organizer cells in the floor plate (the ventral cells of the neural tube and the embryonic foundation of the central nervous system). They also show that FOXA2 specifies the floor plate and actually induces the birth of dopamine neurons. Mice with only a single copy of the foxa2 gene acquire motor deficits and a late-onset degeneration of dopamine neurons. This spontaneous cell death preferentially affects neurons associated with Parkinson disease. This work provides new strategies to generate neurons in the laboratory and to block their death in old age.

Citation: Kittappa R, Chang WW, Awatramani RB, McKay RDG (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol 5(12): e325. doi:10.1371/journal.pbio.0050325

Ronald D.G. McKay
National Institutes of Health
National Institute of Neurological Disorders and Stroke
Bethesda, MD 20892
+1-301-451-8857
mckayr@ninds.nih.gov

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All works published in PLoS Biology are open access. Everything is immediately available—to read, download, redistribute, include in databases, and otherwise use—without cost to anyone, anywhere, subject only to the condition that the original authorship and source are properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commons Attribution License.

 
 
 
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