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Recent News and Articles on the Keywords: prostate cancer + growth factor + progression  Related to the article below (Last Update: 5/13/2008)

Eating less fat may prevent prostate cancer, study shows
Media Newswire (press release), NY - Apr 21, 2008
Aronson believes that lowering dietary fat and increasing levels of the binding protein slows prostate cancer development by cutting off the growth factor ...
Early Postoperative Plasma Transforming Growth Factor-beta1 Is A ...
Medical News Today (press release), UK - Apr 19, 2008
... all which are associated with aggressive prostate cancer (CaP) with occult metastases present at primary treatment with eventual disease progression. ...

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EGFR protects cancer cells from starvation via a kinase ...
EurekAlert (press release), DC - May 5, 2008
Scientists have uncovered a previously unrealized mechanism by which the epidermal growth factor receptor (EGFR), a tyrosine kinase, promotes survival of ...
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Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J CHn Oncol. 2003; 21(14):2787-2799. ...
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Overexpression of the androgen receptor is believed to contribute to the progression of castration-resistant prostate cancer. The declines were consistent ...
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Continued progress has been made towards the completion of Phase 1 clinical trials of IMC-18F1, ImClone?s anti-vascular endothelial growth factor receptor-1 ...IMCL
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Source: Google News

Growth factor involvement in progression of prostate cancer -
PJ Russell, S Bennett, P Stricker - Clinical Chemistry, 1998 - Am Assoc Clin Chem
... Review. Growth factor involvement in progression of prostate cancer. Pamela
J. Russell 1 ,a , Suzanne Bennett 1 , and Phillip Stricker 2 ...

Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone … -
M Gleave - Cancer Research, 1991 - AACR
... Home page, Clin Chem Home page PJ Russell, S. Bennett, and P. Stricker Growth
factor involvement in progression of prostate cancer Clin. ...

… Correlates with Disease Relapse and Progression to Androgen-independence in Human Prostate Cancer -
G Di Lorenzo, G Tortora, FP D'Armiento, G De Rosa, … - Clinical Cancer Research, 2002 - AACR
... Expression of Epidermal Growth Factor Receptor Correlates with Disease Relapse and
Progression to Androgen-independence in Human Prostate Cancer 1. ...

Activation of Mitogen-Activated Protein Kinase Associated with Prostate Cancer Progression 1 -
D Gioeli, JW Mandell, GR Petroni, HF Frierson, MJ … - Cancer Research, 1999 - AACR
... we propose that the transition from paracrine to autocrine loops of growth factor
production and signaling during prostate cancer progression results in the ...

… Contributes to Prostate Cancer Progression by Dramatically Accelerating Prostate Tumor Growth and … -
JR Graff, BW Konicek, AM McNulty, Z Wang, K Houck, … - Journal of Biological Chemistry, 2000 - ASBMB
... cyclin D1 (24) as well as other translationally controlled growth factors and growth
regulatory proteins implicated in human prostate cancer progression (Refs. ...

Transforming growth factor-beta 1 overproduction in prostate cancer: effects on growth in vivo and … -
MS Steiner - Molecular Endocrinology, 1992 - Endocrine Soc
... [Abstract] [Full Text], Home page, Clin Chem Home page PJ Russell, S. Bennett, and
P. Stricker Growth factor involvement in progression of prostate cancer Clin. ...

Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID … -
KA Klein, RE Reiter, J Redula, H Moradi, XL Zhu, … - Nature Medicine, 1997 - nature.com
... prostate specific antigen levels in mice bearing human prostate LNCaP tumors are
determined by tumor volume and endocrine and growth factors. Cancer Res ...

… -like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression … -
SE Dunn - Cancer Research, 1997 - AACR
... Insulin-Like Growth Factor-Binding Proteins, and Prostate Cancer Risk: a ... Rohan Role
of the Insulin-Like Growth Factor Family in Cancer Development and ...

Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression -
H Yu, T Rohan - jnci, 2000 - jnci.oxfordjournals.org
... are predisposed to the development of cancer (1). Recently ... of a potent mitogen,
insulin-like growth factor (IGF)-I ... those of the breast (2), prostate (3), lung (4 ...

In Vivo Progression of LAPC-9 and LNCaP Prostate Cancer Models to Androgen Independence Is … -
T Nickerson, F Chang, D Lorimer, SP Smeekens, CL … - Cancer Research, 2001 - AACR
... growth factor binding protein-5 potentiates insulin-like growth factor-I activity
and accelerates progression to androgen independence in prostate cancer models ...

Source: Google Scholar

Growth factor receptor affects prostate cancer progression

Breeding mice with a gene for a cellular receptor that can be turned on and off-at will-not only enabled researchers at Baylor College of Medicine in Houston to show how prostate cancer progresses, but also provides a model for studying when a drug targeting a gene will have an effect on the cancer.

A report on the work by BCM researchers with fibroblast growth factor receptor 1 appears today in the journal Cancer Cell.

“Since we are manipulating the target gene itself, we can ask, what will happen" If we turn it off, what happens" That recapitulates the effect of a specific drug,” said Dr. David Spencer, professor of immunology at BCM. “By turning the gene on and off at various time points, we can define a ‘susceptibility window’ for that drug, a time in the progression of the disease when the gene would be an appropriate target.”

That therapeutic “window” defines the time when shutting off the gene would also shut down progression of the cancer. Previous studies show that fibroblast growth factor receptor 1 may have a role in initiating prostate cancer, he said. As a result, some companies have developed drugs designed to block the receptor. Spencer’s work looks at what would happen if the receptor is blocked.

In his mouse, he used a synthetic drug that turned the re-engineered fibroblast growth factor receptor on. As the gene product was activated, the prostate gland began dramatic, synchronized changes characteristic of cancer. However, when he withdrew the drug that turned the receptor on, the changes reversed over several weeks until the prostate gland appeared normal.

However, at a certain point, changes in the tissue reach a point of no-return and transform in to a kind of cancer called adenocarcinoma that does not appear to be reversible, although withdrawing the drug can slow the cancer, too.

During this study, Spencer, his graduate student, Victor Acevedo and their colleagues also studied the changes prostate cells undergo while they spread outside the gland and into surrounding tissue. Understanding the events that take place in cells during the transition from normal to cancer can provide important clues about cancer and potential treatments.

From this study, he has identified some of the genes involved in the transition from normal prostate cells within a secretory gland to more migratory, malignant cells outside the gland. Using special gene chips called tumor microarrays, they have also discovered the up regulation or increase in cellular levels of Fzd4, a gene that might prove to be a new marker for human prostate cancer.

“Victor started out looking for a role of fibroblast growth factor receptor 1 in prostate cancer progression and ended up with a new cancer marker and a model for epithelial cell plasticity, rounding out his productive thesis,” Spencer added.

###

Others who took part in this work include Rama D. Gangula, Kevin W. Freeman, Rile Li, Gustavo E, Ayala, Leif E. Peterson and Michael Ittmann, all of BCM, and Youngyou Zhang and Fen Wang of Texas A&M University Health Science Center in Houston.

Funding for this research came from the National Institutes of Health.

After the embargo, the article or an abstract can be found at www.cancercell.org
 
 
 
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