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Recent News and Articles on the Keywords: cancer institute + cancer mutation + cancer  Related to the article below (Last Update: 5/13/2008)

RI gets first nanotechnology center
Jakarta Post, Indonesia -
Joe B. Harford, a cancer researcher for the National Cancer Institute of the US Department of Health and Human Services, said cancer killed more people ...
Foundation grant to help Pitt study cancer-related gene
Pittsburgh Post Gazette, PA - May 11, 2008
Women with either mutation have a 50 percent to 80 percent lifetime risk of developing breast cancer, according to UPMC. The disease also progresses more ...
Previously Unseen Switch Regulates Breast Cancer Response To Estrogen
Science Daily (press release) - May 8, 2008
Women who inherit a mutation in the gene that encodes BRCA1 have up to an 80 percent lifetime risk of developing breast cancer, several times the risk of ...
What the passage of GINA means for the public
Boston Globe, United States - May 11, 2008
An example: Testing for the BRCA gene in breast cancer. It has been shown that if a woman with a high-risk of mutation chooses to have her ovaries and ...
Book Review: Masha Gessen's 'Blood Matters'
International Herald Tribune, France - May 9, 2008
(Of the women who carry a BRCA1 mutation, as many as 85 percent will eventually develop breast cancer, and as many as 50 percent will develop ovarian cancer ...
Interacting Proteins Key To Melanoma Development And Treatment ...
Science Daily (press release) - May 6, 2008
Melanoma is the most deadly form of skin cancer because it metastasizes or moves around the body so quickly. In general, people with advanced-stage disease ...

WSLS.com
BRCA Mutations Don't Spot All High-Risk Women
Washington Post, United States - May 5, 2008
By Serena Gordon MONDAY, May 5 (HealthDay News) -- In women who have been diagnosed with breast cancer, having a known mutation in the BRCA 1 or 2 genes ...
Defying their genes Richmond Times Dispatch
all 14 news articles »
Mechanism Of Action Of Antibiotic Able To Reduce Neuronal Cell ...
Science Daily (press release) - May 9, 2008
"This work not only has implications for the field of neurodegeneration and neurobiology, but may also help us more clearly understand brain cancer, ...
A mother's legacy
Lower Hudson Journal news, NY - May 10, 2008
According to the National Cancer Institute, about 13 percent of all women will develop breast cancer in their lifetime, compared with estimates of 36 to 85 ...
Pitt Cancer Institute announces new research program
Pittsburgh Tribune-Review, PA - May 5, 2008
By The Tribune-Review The University of Pittsburgh Cancer Institute today announced a multimillion-dollar research program to study two genes that, ...
Source: Google News

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy -
JG Paez, PA Janne, JC Lee, S Tracy, H Greulich, S … - Science, 2004 - sciencemag.org
... To investigate whether EGFR mutations might be a determinant of gefitinib sensitivity ...
than 125 patients treated at the Dana-Farber Cancer Institute either on an ...

Gene-expression profiles in hereditary breast cancer -
I Hedenfalk, D Duggan, Y Chen, M Radmacher, M … - New England Journal of Medicine, 2001 - content.nejm.org
... Our results suggest that a heritable mutation influences the gene ... BW), National Human
Genome Research Institute, and the Division of Cancer Treatment and ...

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial … -
CR Boland - Cancer Research, 1998 - AACR
... In December 1997, the National Cancer Institute sponsored "The ... and RER Phenotypes
in Cancer Detection and ... ie, have insertion/deletion mutations), and low ...

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer … -
D Liaw, DJ Marsh, J Li, PLM Dahia, SI Wang, Z … - Nature Genetics, 1997 - nature.com
... Germline mutations of the PTEN gene in Cowden disease, an inherited breast and ... 4
Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, D920C ...

The risk of cancer associated with specific mutations of BRCA 1 and BRCA 2 among Ashkenazi Jews -
JP Struewing, P Hartge, S Wacholder, SM Baker, M … - New England Journal of Medicine, 1997 - content.nejm.org
The Risk of Cancer Associated with Specific Mutations of BRCA1 and BRCA2 ... the Division
of Cancer Epidemiology and Genetics, National Cancer Institute (JPS, PH ...

… Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting Highlights … -
MA Rodriguez-Bigas, CR Boland, SR Hamilton, DE … - COMMENTARY, 1997 - jnci.oxfordjournals.org
... of the HNPCC syndrome with germ- line mismatch repair gene mutations (MMR ... and 12,
1996, the Early Detection Branch of the National Cancer Institute convened an ...

Preferential Formation of Benzo [a] pyrene Adducts at Lung Cancer Mutational Hotspots in P53 -
MF Denissenko, A Pao, M Tang, GP Pfeifer - Science, 1996 - sciencemag.org
... BPDE (obtained from the National Cancer Institute repository, Midwest Research
Institute, Kansas City, MO ... for Detection of DNA Damage and Mutations, G. P ...

[PDF] Mutations of the BRAF gene in human cancer -
H Davies, GR Bignell, C Cox, P Stephens, S Edkins, … - Nature, 2002 - sherpa.leeds.ac.uk
... Kong 17 Abramson Family Cancer Research Institute, University of Pennsylvania Cancer
Center, Philadelphia ... owing to the accumulation of mutations in critical ...
-

Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations -
TR Rebbeck, HT Lynch, SL Neuhausen, SA Narod, L … - New England Journal of Medicine, 2002 - content.nejm.org
... cancer and breast cancer in women with BRCA1 or BRCA2 mutations. ... TRR), Cancer Center
(TRR, BLW), and Abramson Family Cancer Institute (BLW), University of ...

Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification -
ME Gorre, M Mohammed, K Ellwood, N Hsu, R Paquette … - Science, 2001 - sciencemag.org
... A fragment containing the C T mutation at ABL nt 944 was made by PCR ... by grants from
the Leukemia and Lymphoma Society, the National Cancer Institute (CLS) and ...

Source: Google Scholar

OHSU Cancer Institute researcher discovers what fuels certain cancer mutation

ATLANTA– An Oregon Health & Science University Cancer Institute researcher has discovered that a particular hormone is responsible for driving a cancer enzyme to cause an often deadly red blood cell cancer.

Researchers working with the cancer mutation in the JAK2 enzyme have found that the enzyme is dependent on the hormone TNF-alpha to grow and cause a red blood cell cancer called polycythemia vera, said principal investigator Thomas Bumm, M.D., Ph.D., OHSU Cancer Institute member.

This research will be presented at the American Society of Hematology annual meeting in Atlanta on Monday, Dec. 10, at 3:30 p.m.

Polycythemia vera is a disease in which there are too many red blood cells in the bone marrow and blood, causing the blood to thicken. There is no cure.

Mice with normal TNF-alpha production and the JAK2 mutation developed the red blood cell disease very quickly – within two to three weeks. The blood became very thick, and they developed severe bone marrow fibrosis, excessive fibers in the bone marrow with a decrease in healthy cells. In contrast, mice without the hormone but carrying the JAK2 mutation had normal red blood cell levels and normal bone marrow.

The hormone, TNF-alpha is known as a highly potent hormone, but until now its role in cancer has not been well understood.

“If these specific hormones are understood, then there is hope to find a new way to fight these cancer cells by attacking the specific hormones triggering the cancer cells,” said Bumm, a fellow in hematology/ medical oncology, OHSU School of Medicine.

There are already drugs developed that target TNF-alpha used for patients with auto immune and inflammatory diseases such as rheumatoid arthritis. But the drugs have not been used for cancer patients. Bumm said one of the next steps will be to conduct studies on a larger mouse study and also testing these different drugs’ effect on this JAK2-induced cancer.

“Maybe one of these drugs will work on the mice and is safe so that we could begin testing the drugs on patients. At this point, there is no specific treatment for polycythemia vera cancer patients. Maybe we opened a new door to understand leukemia better and to fight it at a crucial root,” Bumm said.

Polycythemia vera is rare, about five in every 1 million people have it. Without treatment, about half the people who have polycythemia vera with symptoms die in less than two years.

Often, people with polycythemia vera have no symptoms for years. The earliest symptoms usually are weakness, fatigue, headache, light-headedness, shortness of breath and night sweats. Vision may be distorted, and a person may have blind spots or may see flashes of light. Bleeding from the gums and more bleeding than would be expected from small cuts are common. The skin, especially the face, may look red. A person may itch all over, particularly after bathing or showering.

###

This research is abstract #675.

The OHSU Cancer Institute is the only National Cancer Institute-designated center between Sacramento and Seattle. It comprises some 120 clinical researchers, basic scientists and population scientists who work together to translate scientific discoveries into longer and better lives for Oregon's cancer patients. In the lab, basic scientists examine cancer cells and normal cells to uncover molecular abnormalities that cause the disease. This basic science informs more than 200 clinical trials conducted at the OHSU Cancer Institute.

 
 
 
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