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Recent News and Articles on the Keywords: combining medication + combine study + medication  Related to the article below (Last Update: 5/13/2008)

Whitewashing Toxic Chemicals
HealthNewsDigest.com, NY - May 4, 2008
The study will be a meta-analysis, combining existing individual studies to, he says, produce more-authoritative conclusions. Some of the earlier studies ...
Science and Recovery in Schizophrenia
Psychiatric Services (subscription) - May 1, 2008
In addition, current psychotherapies (154), self-help programs (155), and peer-directed medication management (156) emphasize the process of hope and taking ...
Source: Google News

Comparing and Combining Naltrexone and Acamprosate in Relapse Prevention of Alcoholism A Double- … -
F Kiefer, H Jahn, T Tarnaske, H Helwig, P Briken, … - Archives of General Psychiatry, 2003 - Am Med Assoc
... controlled study comparing and combining both compounds. ... The combined medication
was most effective with significantly ... The results of this study support the ...

… and Behavioral Interventions for Alcohol Dependence The COMBINE Study: A Randomized Controlled … -
RF Anton, SS O'Malley, DA Ciraulo, RA Cisler, D … - JAMA, 2006 - Am Med Assoc
... by the US Food and Drug Administration, naltrexone ... study has evaluated whether combined
pharmacotherapy with ... it is unclear 16 whether combining naltrexone (an ...

… Using One-week Triple Therapies Combining Omeprazole with Two Antimicrobials: The MACH I Study -
T Lind, SV Zanten, P Unge, R Spiller, E … - Helicobacter, 1996 - Blackwell Synergy
... The two most effective therapies were those combining omeprazole, 20 mg ... ing, compliance
was assessed by counting returned study medication, and laboratory ...

Patient compliance with inhaled medication: does combining beta-agonists with corticosteroids … -
CM Bosley, DT Parry, GM Cochrane - European Respiratory Journal, 1994 - Eur Respiratory Soc
... Patient compliance with inhaled medication: Does combining beta-agonists ... compliance
with an inhaled corticosteroid may be greater if it is combined with a ...

[CITATION] Combining Methylphenidate and Clonidine: A CLINICALLY SOUND MEDICATION OPTION. -
TE WILENS, TJ SPENCER - Journal of the American Academy of Child & Adolescent …, 1999
... the widespread atten- tion to the drug, cases are ... 48:324-328 Popper CW (1995), Combining
methylphenidate and ... treatment with the use of combined clonidine and ...

[PDF] Combining statistical learning with a knowledge-based approach-a case study in intensive care … -
K Morik, P Brockhausen, T Joachims - Proceedings of the Sixteenth International Conference on …, 1999 - www-ai.informatik.uni-dortmund.de
Combining statistical learning with a knowledgebased approach | A case ... The paper
describes a case study in combin- ing ... how to change the dose of which drug. ...
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Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-analysis of Prospective Studies -
J Lazarou, BH Pomeranz, PN Corey - JAMA: The Journal of the American Medical Association, 1998 - jama.waldenu.edu
... Combining these values, overall 2216000 (95% CI, 1721000-2711000 ... well as ADRAd,
(2) we combined ADRAd and ... study on ADRs, which excludes medication errors, had a ...
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COMBINED MEDICATION AND PSYCHOTHERAPY IN THE TREATMENT OF CHRONIC MOOD DISORDERS -
IW Miller, GI Keitner - Psychiatric Clinics of North America, 1996 - Elsevier
... combined treatment? refers to combining two or ... is congruent with a combined,
biopsychosocial treatment ... reviewed the literature on medication and individual ...

[PDF] Medication and psychotherapy in the treatment of bulimia nervosa -
BT Walsh, GT Wilson, KL Loeb, MJ Devlin, KM Pike, … - Am J Psychiatry, 1997 - hawaii.edu
... Medication Only (N=28) Combined (N=120) Mean SD ... The clinical characteristics of the
patients treated in this study are presented in tables 2 and 3. On average ...
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Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a … -
JC Nelson, CM Mazure, PI Jatlow, MB Bowers, LH … - Biological Psychiatry, 2004 - Elsevier
... proof of the concept that combining norepinephrine and ... of treatment resistance or
by drug plasma concentrations ... nor meaningfully greater with combined treatment ...

Source: Google Scholar

Combination therapy including antibiotics may be beneficial for multiple sclerosis

 

A preliminary study suggests that combining a medication currently used to treat multiple sclerosis with an antibiotic may slow the progress of the disease, according to an article posted online today that will appear in the February 2008 print issue of Archives of Neurology, one of the JAMA/Archives journals.

“Multiple sclerosis (MS) is an immune-mediated disorder that affects genetically susceptible individuals after exposure to certain, as yet unidentified environmental antigens,” or disease-causing agents, the authors write as background information in the article. The development of MS involves inflammation that destroys parts of the brain along with progressive degeneration of brain tissue. The most common type is relapsing-remitting MS, in which patients experience attacks of symptoms such as muscle weakness and spasms followed by periods of symptom-free remission. Many patients with relapsing-remitting MS who take interferon, a medication that boosts the immune system and fights viruses, still experience relapses and may continue to develop new areas of damaged brain tissue (lesions) visible on magnetic resonance imaging (MRI).

Alireza Minagar, M.D., of Louisiana State University Health Sciences Center, Shreveport, and colleagues conducted a single-center trial involving 15 patients (average age 44.5) with relapsing-remitting MS who had been taking interferon for at least six months and were experiencing symptoms and developing new brain lesions. For four months, participants took 100 milligrams daily of the antibiotic doxycycline in addition to continuing interferon therapy. They underwent monthly neurological examinations, MRI to detect brain lesions and blood work to monitor safety.

After four months, the combination treatment resulted in fewer lesions visible on MRI—60 percent of the patients had more than a one-fourth reduction in the number of lesions from the beginning of the study. The patients also had reduced average scores on a scale designed to assess disability levels. Only one patient relapsed; adverse effects were mild and included only known effects of the two drugs individually rather than new effects associated with combining the medications.

Antibiotics in the tetracycline family, including doxycycline, may be effective against MS and other inflammatory diseases by inhibiting the action of enzymes that destroy certain nervous system cells, protecting the brain and increasing the effectiveness of the immune system, the authors note.

“There is growing interest in combination therapy in patients with MS to stabilize the clinical course, reduce the rate of clinical relapses and decelerate the progressive course of the underlying pathologic mechanism,” they write. “Overall, data from this cohort suggest that the treatment combination of oral doxycycline and interferon beta-1a may be safe and effective in some patients with MS; however, further controlled clinical trials are warranted to demonstrate safety and efficacy in a larger patient population.”

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(Arch Neurol.2008;65(2):(doi:10.1001/archneurol.2007.41). Available pre-embargo to the media at www.jamamedia.org.)

Editor’s Note: Authors Dr. Minagar and Dr. Alexander have received independent medical grants from Bayer Pharmaceuticals and EMD Serono. This work was supported by an independent medical grant from Biogen Idec Inc. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

 
 
 
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