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Recent News and Articles on the Keywords: stem cell + of follicular + follicular  Related to the article below (Last Update: 7/1/2008)

Letter: Cancer survivor backs Relay for Life
Billings Gazette,  USA - Jun 23, 2008
I am a follicular-lymphoma survivor due to a stem cell transplant that was done here at home. I was first diagnosed with follicular lymphoma in November ...
Sequential R-CHOP and Ibritumomab Tiuxetan (Zevalin(R)) Regimen ...
FOXBusiness - Jun 9, 2008
Treatment options for patients who are ineligible for autologous stem cell transplant are limited. In this analysis, of the 63 patients enrolled on the ...
Clinic Roundup
TMCnet - Jun 9, 2008
The results suggested that adding galiximab to rituximab may be a promising regimen for patients with follicular lymphoma, a common type of non-Hodgkin ...
Investigational Studies Highlight Potential Utility of Zevalin(R ...
FOXBusiness - Jun 2, 2008
"These two studies add to the increasing body of data suggesting that radioimmunotherapy may be a useful adjunct to stem cell transplantation in late stage ...
Article by HairlossTalk.com
Hairloss Talk Newsletter - Jun 12, 2008
Each follicle, whether in mice, rats or humans, contained about 1500 stem cells, which could migrate and develop into glands, hair or skin, ...
BUYINS.NET: FVRL, GNVC, HYDG, OESX, OSCI, PHHM Have Also Been ...
Trading Markets (press release), CA - Jun 20, 2008
... a following rituxan induction therapy, which is in phase II trial for treating -naive or relapsed or refractory follicular B-cell NHL patients; ...FVRL

Daily Mail
Feeling a bit thin on top? This cloning
Times Online, UK - Jun 2, 2008
The new technique, known as ?follicular cell implantation?, has already shown positive results in continuing clinical trials on human beings. ...
Hair Replacement Sector Looks to Cloning for New Results RedOrbit
all 18 news articles »
Individualizing Cancer Therapies Using "Anatomolecular" Imaging
RedOrbit, TX - Jun 25, 2008
The authors concluded that Zevalin consolidation of first remission in advanced-stage follicular lymphoma is highly effective, resulting in a total response ...
Accentia Reports on Multiple Sclerosis Study: Revimmune? Shows ...
Lifescience-online, Switzerland - Jun 18, 2008
These late-stage products include: BiovaxID?, a novel anti-idiotype cancer vaccine for the treatment of B-cell malignancies including indolent follicular ...ABPI
Clinical Data For REVLIMID(R) And VIDAZA(R) In Important Blood ...
RedOrbit, TX - Jun 18, 2008
According to NHL histology, objective response was 36 percent in mantle cell lymphoma, 22 percent in diffuse large b-cell lymphoma, 33 percent in follicular ...CLDA
Source: Google News

Germline Stem Cells and Follicular Renewal in the Postnatal Mammalian Ovary. -
J Johnson, J Canning, T Kanedo, JK Pru, JL Tilly - Obstetrical & Gynecological Survey, 2004 - obgynsurvey.com
... Germline Stem Cells and Follicular ... unlike males who retain germline stem cells (GSCs)
through ... ovaries have mitotically active germ cells that continuously ...

Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis -
G Taylor, MS Lehrer, PJ Jensen, TT Sun, RM Lavker - Cell, 2000 - Elsevier
... that hair follicular stem cells, located in the bulge region, can give rise to several
cell types of the hair follicle as well as upper follicular cells. ...

?-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin -
J Huelsken, R Vogel, B Erdmann, G Cotsarelis, W … - Cell, 2001 - Elsevier
... Recent findings revealed that these follicular stem cells are bipotent, as they
give rise to both keratinocytes of the hair follicle and the interfollicular ...

… stem cell transplantation in first remission prolongs progression-free survival in follicular …
G LENZ, M DREYLING, E SCHIEGNITZ, R FORSTPOINTNER, … - Blood, 2004 - cat.inist.fr
... de consolidaci?n; R?mission; Remission; Remisi?n; Cellule souche; Stem cell; C?lula
primitiva; Lymphome folliculaire; Follicular lymphoma; Linfoma folicular ...

Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular … -
K van Besien, FR Loberiza Jr, R Bajorunaite, JO … - Blood, 2003 - bloodjournal.hematologylibrary.org
... THERAPEUTIC TRIALS. Comparison of autologous and allogeneic hematopoietic
stem cell transplantation for follicular lymphoma. Koen van ...

… stem-cell transplantation and doxorubicin-based chemotherapy in patients with advanced follicular … -
E Deconinck, C Foussard, N Milpied, P Bertrand, P … - Blood, 2005 - ncbi.nlm.nih.gov
... High-dose chemotherapy with stem-cell support is effective in follicular lymphoma
in relapse but remains controversial as a first-line therapy. ...

… and autologous hematopoietic stem cell transplantation for relapsed follicular non-Hodgkin lymphoma … -
AK Gopal, TA Gooley, DG Maloney, SH Petersdorf, JF … - Blood, 2003 - bloodjournal.hematologylibrary.org
... High-dose radioimmunotherapy versus conventional high-dose therapy and autologous
hematopoietic stem cell transplantation for relapsed follicular non-Hodgkin ...

… With Relapsed or Refractory Low-Grade, Follicular, or Transformed B-Cell Non-Hodgkin's Lymphoma -
TE Witzig, LI Gordon, F Cabanillas, MS Czuczman, C … - Journal of Clinical Oncology, 2002 - jco.ascopubs.org
... may be combined with high-dose chemotherapy with stem-cell rescue. ... advance in the
treatment of relapsed or refractory low-grade, follicular, or transformed NHL ...

Follicular cells of the thyroid gland require Pax8 gene function -
A Mansouri, K Chowdhury, P Gruss - Nat Genet, 1998 - nature.com
... endoderm primordia into thyroxin-producing follicular cells. ... by homologous recombination
in embryonic stem cells. in Cell Biology: A Laboratory Handbook (ed ...

Is radiotherapy curative for stage I and II low-grade follicular lymphoma? Results of a long-term … -
MP Mac Manus, RT Hoppe - Journal of Clinical Oncology, 1996 - jco.ascopubs.org
... High-dose radioimmunotherapy versus conventional high-dose therapy and autologous
hematopoietic stem cell transplantation for relapsed follicular non-Hodgkin ...

Source: Google Scholar

Gentler chemotherapy before stem cell transplant causes long-term remission of follicular lymphoma

ATLANTA - Treating relapsed follicular lymphoma patients with a milder chemotherapy regimen before they receive a blood stem cell transplant from a donor resulted in long-term complete remission for 45 of 47 patients in a clinical trial, researchers at The University of Texas M. D. Anderson Cancer Center report at the 49th annual meeting of the American Society of Hematology.

The two patients who had relapsed after the treatment regained a complete response after additional therapy.

"Our results show that this approach may actually be curative of follicular lymphoma," says lead author Issa Khouri, M.D., professor in M. D. Anderson's Department of Stem Cell Transplantation. "No other treatments produce this type of response."

The traditional treatment before receiving a matched stem cell donation consists of higher-dose chemotherapy that kills the lymphoma cells and shuts down the patient's own blood-producing stem cells - a process called myeloablation. While waiting for the donor's stem cells to engraft in the bone marrow and to begin producing blood, patients are vulnerable to infection, bleeding, and anemia.

Early research by Khouri and colleagues indicated that using a nonmyeloablative chemotherapy approach could control the lymphoma while sparing patients the side effects of high-dose chemotherapy. The transplanted blood stem cells launch an immune system attack on the lymphoma, a process called graft-vs.-lymphoma immunity.

"Our early results were encouraging. But with follicular lymphoma you need a long follow-up to see if the results hold," Khouri says. "This disease tends to recur later on, sometimes years after chemotherapy."

All patients in the present trial have been followed for at least five years, some for up to nine years. Trial patients had received 2 to 7 different chemotherapy regimens. Eight had received transplants of their own stem cells. At transplantation, 29 were in partial remission and 18 were in complete remission.

All 47 achieved complete remission after receiving matched blood stem cells from donors. One patient relapsed at 18 months. After receiving a donor lymphocyte infusion, the patient began a continuous complete response at 24 months. The other patient relapsed at 20 months and was found to have graft failure. Since treatment with rituximab, this patient has been in complete remission for four years.

Seven patients died during the trial, none from follicular lymphoma, Khouri notes. The 40 remaining patients all remain in remission. Overall survival at six years is 85 percent and current progression-free survival is 83 percent.

Acute graft-vs.-host disease (GVHD) arose in 11 percent of patients. Another 51 percent had chronic graft-vs.-host disease. GVHD was treated with immunosuppressive therapy. Khouri notes that only five patients in the study group remain on immunosuppressive therapy.

Long-term follow-up also allowed researchers to thoroughly gauge side effects, or toxicity, of the non-myeloablative approach. "It reduces toxicity significantly," Khouri says. "Even elderly patients can have this done."

Patients received fludarabine, cyclophosphamide and rituximab for three days before transplantation. Tacrolimus and methotrexate were used to prevent graft-vs.-host disease.

Follicular lymphoma is a Non-Hodgkin lymphoma, with about 12,000 new cases diagnosed annually.

###

Co-authors with Khouri are Rima M. Saliba, Martin Korbling, Chitra Hosing, Luis Fayad, Ming S. Lee, Felipe Samaniego, Barry I. Samuels, Daniel Couriel, Fredrick Hagemeister, Peter McLaughlin and Richard Champlin, all of M. D. Anderson.
 
 
 
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