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Recent News and Articles on the Keywords: johns hopkins + researchers have + researchers  Related to the article below (Last Update: 5/5/2008)

Ethnicity Plays Role in Parents' Treatment of Childhood Fever
Washington Post, United States - 11 minutes ago
MONDAY, May 5 (HealthDay News) -- Most parents have some misconceptions about their children's fever and overtreat mild cases, a Johns Hopkins Children's ...
The plight of the older sibling
MSNBC -
?The folklore is that parents punish the older child more than the younger ones,? says Lingxin Hao, a sociology professor at Johns Hopkins University and an ...
Gwyneth legs it to good health
The Sun, UK -
Tall women, and men with a long reach are less likely to develop Alzheimer?s, researchers at Johns Hopkins University in the US have discovered. ...
You Are What You Eat? Maybe Not the Case for Ancient Man
Johns Hopkins Gazette, MD -
By Audrey Huang Careful analysis of microscopic abrasions on the teeth of early human "cousins" by researchers at Johns Hopkins, University of Arkansas, ...

Johns Hopkins Gazette
Urban Health Institute Hosts Baltimore Research Day
Johns Hopkins Gazette, MD -
Participants will include policy-makers and students and researchers from a number of universities and community groups, including Johns Hopkins, ...
Two From JHU Elected to National Academy of Sciences Johns Hopkins Gazette
all 2 news articles »

National Post
Lanky people may avoid Alzheimer's
The Press Association - 48 minutes ago
Leggy women and lanky men not only have a height advantage, they are less likely to develop Alzheimer's. Researchers found a link between short limbs and a ...
Short Arms And Legs Linked To Risk Of Dementia, Study Shows Science Daily (press release)
all 34 news articles »
Cryoablation Promising for Renal Tumors
Renal and Urology News, NY -
Using this technique, researchers have found it produces good short-term follow-up results with no major complications. ?This interventional radiology ...
Heart Failure Patients May Suffer Similarly To Advanced Cancer ...
Science Daily (press release) - May 2, 2008
ScienceDaily (May 2, 2008) ? Researchers compared 60 heart failure outpatients to 30 outpatients with advanced cancer being treated at Johns Hopkins ...
Commonly Used Medications Associated With Impaired Physical ...
Science Daily (press release) -
Co-researchers were James Lovato, MS, Jeff Williamson, MD, Hal Atkinson, MD, and David Goff, MD, all with Wake Forest, Michelle Carlson, Ph.D., with Johns ...
Are parents stricter with older kids?
Times of India, India - May 3, 2008
... Duke University and The Johns Hopkins University, used economic game theory to predict levels of parental discipline. The researchers predicted that ...
Source: Google News

[CITATION] XV. Recent Advances in Research on the Ecology of Human Development
U BRONFENBRENNER - Development As Action in Context: Problem Behavior and …, 1986 - Springer-Verlag

School/family/community Partnerships: Caring for the Children We Share. -
JL Epstein - Phi Delta Kappan, 1995 - questia.com
... Schools have choices. ... Researchers and staff members at Johns Hopkins will disseminate
information and guidelines, send out newsletters, and hold ...

Issues and Opinion on Structural Equation Modeling -
WW Chin - Management Information Systems Quarterly, 1998 - misq.org
... have appeared to support researchers interested in ... Issues, Debates, and Strategies,
Johns Hopkins University Press ... Studies of Statistical Power Have an Effect ...

New tumor suppressor may rival p53 -
J Marx - Science, 1994 - sciencemag.org
... Researchers have the first evidence that an intrinsic ... gene expert Bert Vogelstein
of Johns Hopkins University School ... suppressor might also have broad practical ...

[BOOK] Success for All: Research and Reform in Elementary Education -
RE Slavin, NA Madden - 2001 - books.google.com
... Development, research, and dissemination in Britain is ... volume, many other researchers
have been involved ... and Nancy Karweit of Johns Hopkins University; Barbara ...

Debate Surges Over the Origins of Genomic Defects in Cancer -
J Marx - Science, 2002 - sciencemag.org
... in cancer, says Bert Vogelstein of Johns Hopkins University School ... But those
calculations have been questioned by other researchers, including Ian ...

Gene therapy's growing pains -
E Marshall - Science, 1995 - sciencemag.org
... cystic fi- -F): Several CF protocols have ed because ... agent isfer genes, and some
researchers lenovirus-based ... Drew Par- _ doll, a Johns Hopkins University co ...

[BOOK] Neighborhoods and Health -
I Kawachi, LF Berkman - 2003 - books.google.com
... If the chapters that follow inspire researchers and policy ... of populations, then we
will have accomplished our ... on Aging and Health Johns Hopkins Bloomberg School ...

Evidence-Based Education Policies: Transforming Educational Practice and Research -
RE Slavin - Educational Researcher, 2002 - edr.sagepub.com
... the 1890s, William Halsted at Johns Hopkins University in ... 2002) and other educational
researchers (see, for example, Mosteller & Boruch, 2002) have been arguing ...

affy-analysis of Affymetrix GeneChip data at the probe level -
L Gautier, L Cope, BM Bolstad, RA Irizarry - Bioinformatics, 2004 - Oxford Univ Press
... Biostatistics, Johns Hopkins University, 615 N. Wolfe St E3035 ... Several researchers
have developed their own summaries of ... this is an area of continuing research. ...

Source: Google Scholar

Silencing small but mighty cancer inhibitors

 

Researchers from Johns Hopkins and the University of Pennsylvania have uncovered another reason why one of the most commonly activated proteins in cancer is in fact so dangerous. As reported in Nature Genetics this week, the Myc protein can stop the production of at least 13 microRNAs, small pieces of nucleic acid that help control which genes are turned on and off.

What’s more, in several instances, re-introducing repressed miRNAs into Myc-containing cancer cells suppressed tumor growth in mice, raising the possibility that a sort-of gene therapy approach could be effective therapy for treating certain cancers.

A research team led by Joshua Mendell, M.D., Ph.D., assistant professor at the McKusick-Nathans Institute of Genetic Medicine, previously found that Myc could turn on one particular group of growth-promoting miRNAs called the miR-17-92 cluster in lymphoma cells. His team, along with Andrei Thomas-Tikhonenko’s lab at the University of Pennsylvania, now took a broader approach and analyzed more than 300 miRNAs in both human and mouse lymphoma cells.

In those cells that had high amounts of Myc protein, the researchers found significant changes in the quantities of at least 13 miRNAs. “The surprising aspect, considering our miR-17-92 results,” says Tsung-Cheng Chang, lead author on the study, “is that lots of Myc turns everything off, not on.”

When they looked closer at the DNA of the lymphoma cells, the team also found that Myc was directly attaching to the DNA at the miRNA genes. “This was further evidence that the decrease in miRNA levels was directly due to the action of Myc,” says Chang.

“This study expands our understanding of how Myc acts as such a potent cancer-promoting protein,” says Mendell. “We already knew that it can directly regulate thousands of genes. Through its repertoire of miRNAs, Myc likely influences the expression of thousands of additional genes. Activation of Myc therefore profoundly changes the program of genes that are expressed in cancer cells.”

“Still, we needed to determine whether any of these Myc-regulated microRNAs played a direct role in cancer,” adds Thomas-Tikhonenko. His team then individually reintroduced several of the repressed miRNAs into mouse lymphomas that also had high levels of Myc and measured the effect on lymphoma progression in animals. They found that more than five of the miRNAs could stop cancer growth. “While this result was not entirely surprising, we had no idea that cancer suppression by microRNAs could be so powerful,” admits Thomas-Tikhonenko. Mendell also notes that RNA-based therapies have had some success in animal models, and researchers might potentially find a wide range of miRNAs that can stop cancers in their tracks.

###

The research was funded by the National Institutes of Health.

Authors on the paper are Duonan Yu and Andrei Thomas-Tikhonenko of the University of Pennsylvania and Tsung-Cheng Chang, Yun-Sil Lee, Erik Wentzel, Dan Arking, Kristin West, Chi Dang and Joshua Mendell of Hopkins.

On the Web:
www.hopkinsmedicine.org/geneticmedicine/People/Faculty/mendell.html
www.nature.com/ng/index.html
 
 
 
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