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Recent News and Articles on the Keywords: penn researcher + immune + penn  Related to the article below (Last Update: 5/5/2008)

Study could ease worry about preemie immunizations
Pittsburgh Tribune-Review, PA -
The study was conducted at 10 medical facilities, including West Penn and the Children's Home and Lemieux Family Center in Garfield, between September 2000 ...
Scientists plan to engineer HIV-resistant cells
Daily Pennsylvanian, PA - Apr 18, 2008
In a few months, Penn researchers may simultaneously transform HIV treatment and the entire technology of gene therapy. Researchers are submitting a ...
Cracking the mystery of the human body's immunity memory
Bloomington Pantagraph,  USA - Apr 6, 2008
"I got to see the data as they came running out of their lab," recalls Thompson, director of Penn?s Abramson Cancer Center. "It was a series of eureka ...

The Associated Press
Gene therapy experiments improve vision in nearly blind
The Associated Press - Apr 28, 2008
... an experiment for a liver disorder at Penn. And some children treated for an immune disorder called the "bubble boy disease" later developed leukemia. ...
Source: Google News

The nature of selection on the major histocompatibility complex. -
V Apanius, D Penn, PR Slev, LR Ruff, WK Potts - Crit Rev Immunol, 1997 - ncbi.nlm.nih.gov
... Apanius V, Penn D, Slev PR, Ruff LR, Potts WK ... to pathogen evasion of MHC-dependent
immune recognition ... Additional research is needed to discriminate between these ...

CLINICAL TRIALS: Gene Therapy Death Prompts Review of Adenovirus Vector -
E Marshall - Science, 1999 - sciencemag.org
... connected with the University of Pennsylvania's Institute for ... to what happened, the
Penn team discovered ... One researcher publicly challenged the notion that ...

Chemical signals and parasite-mediated sexual selection -
D Penn, WK Potts - Trends in Ecology & Evolution, 1998 - Elsevier
... Dustin Penn 1 and Wayne K. Potts 2 Dept of ... honestly reveal his parasite load[6].
Research on parasite ... compatibility at loci that control immune recognition of ...

The Scent of Genetic Compatibility: Sexual Selection and the Major Histocompatibility Complex -
DJ Penn - Ethology, 2002 - Blackwell Synergy
... conditions, rather than simply examining immune responsiveness or ... genetics (Potts
& Wakeland 1993; Penn & Potts ... Research on MHC and mate choice in humans is ...

… transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune … -
CS Manno, GF Pierce, VR Arruda, B Glader, M Ragni, … - Nat Med, 2006 - palgrave-journals.com
... AAV-Factor IX and limitations imposed by the host immune response. ... Medical Institute,
3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA ... RESEARCH. ...

The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency … -
… Mutton, BA Pearson, R Storer, JM Cameron, CR Penn - Antimicrobial Agents and Chemotherapy, 1992 - pubmedcentral.nih.gov
... Pearson, R Storer, JM Cameron, and CR Penn Department of Virology, Glaxo Group Research
Ltd., Greenford ... patient at risk for acquired immune deficiency syndrome ...

KAPOSI'S SARCOMA IN TRANSPLANT RECIPIENTS. -
I Penn - Transplantation, 1997 - transplantjournal.com
... 1 Address correspondence to: Israel Penn, MD, Department of ... it is not associated
with immune depression apart from ... recipients, studied by the research group of ...

Role of Vector in Activation of T Cell Subsets in Immune Responses against the Secreted Transgene … -
PA Fields, DW Kowalczyk, VR Arruda, E Armstrong, … - Molecular Therapy, 2000 - nature.com
... University of Pennsylvania, Philadelphia, Pennsylvania 19104. ... of Philadelphia, Abramson
Research Center, Room 310 ... Defining immune responses against the secreted ...

Cancer is a complication of severe immunosuppression. -
I Penn - Surg Gynecol Obstet, 1986 - ncbi.nlm.nih.gov
... Penn I. Diverse states of immunodeficiency are complicated by the development of
various types of ... is a high incidence of a neoplasm of the immune system itself ...

Untrained mice discriminate MHC-determined odors. -
D Penn, WK Potts - Physiol Behav, 1998 - ncbi.nlm.nih.gov
... Penn@biology.utah.edu Immune recognition occurs when foreign antigens are presented
to T ... Publication Types: Research Support, US Gov't, Non-PHS. MeSH Terms ...

Source: Google Scholar

Researchers led by Penn vet uncover the delicate protein balance behind the immune system response

PHILADELPHIA -– A team of researchers from the University of Pennsylvania School of Veterinary Medicine has identified the protein interactions involved in the immune system process that fights infection yet, in certain inflammatory diseases, runs amok and attacks friendly tissue.

The Penn team, led by Christopher Hunter, chair of the Department of Pathobiology at Penn Vet, has identified the pathways that lead to the production of the signaling protein, or cytokine, Interleukin 10 (IL-10) which plays an important role in regulating the balance between the protective white blood, or T, cell response and one that is pathological and out of control.

While IL-10 has long been recognized as a major anti-inflammatory factor, the events that lead to its production have been poorly understood. According to the researchers’ findings, messenger proteins Interleukin 27, or a combination of Interleukin 6 and another type of messenger molecule called transforming growth factor beta, induce production of IL-10. These results suggest that modulating these messenger molecules could increase IL-10 concentrations that temper overactive immune responses.

This information sheds new light on the immune-system response and may provide directed means to intervene in severe autoimmune diseases such as colitis, multiple sclerosis and arthritis.

“The deeper we delve into the role of cytokines in the immune system response, the more we realize that they are part of an elaborately balanced system kept in check by the conflicting regulatory functions of the cytokines themselves,” Hunter said. “When combined with the work from our colleagues at Schering Plough, Harvard and Jefferson University, these studies provide new insights into the pathways that can be used to temper autoimmune inflammation.”

Although there are many sources of IL-10 in the body, the details of how it is synthesized were poorly understood. Hunter’s team determined that the process begins with cytokines IL-27 and IL-6 inducing production Th1 , Th2 and Th17 T cells and concludes that cytokines like IL-27 can promote the ability of these cells to produce IL-10. The effect was dependent on the transcription factors STAT1 and STAT3 for IL-27 and on STAT3 for IL-6.

Researchers tested this hypothesis by removing the IL-27 receptor from genetically engineered mice. Once infected with disease, the mice were unable to generate T cells producing IL-10.

In prior studies, Penn researchers learned that Interluekin-27 was involved in the immune-system response by limiting the duration and intensity of white blood activation, an "off switch" to the cascade of messenger proteins that serve to further activate the immune system. Prior to their research, the general assumption among scientists was that IL-27 promoted inflammation.

###

The research was performed by Jason Stumhofer, Jonathan Silver, Tajie Harris and Hunter of the Department of Pathobiology at Penn Vet; Arian Laurence and John O'Shea of the Molecular Immunology and Inflammation Branch of the National Institute of Arthritis and Muskoskeletal and Skin Diseases; Paige Porrett and Laurence Turka of Penn’s School of Medicine; Matthias Ernst of the Ludwig Institute for Cancer Research in Victoria, Australia; and Christiaan Saris of the Department of Inflammation Research in Thousand Oaks, Calif.

The study was supported by the National Institutes of Health, Scholler Foundation, Marie Lowe Cancer Center, Commonwealth of Pennsylvania and National Health and Medical Research Council of Australia.


 
 
 
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