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Recent News and Articles on the Keywords: new antidepressants + risks, us + new  Related to the article below (Last Update: 5/5/2008)

New Data on SEROQUEL XR(TM) in Treatment of Both Major Depressive ...
RedOrbit, TX - 9 minutes ago
(11) "New MDD therapy options are clearly needed. Studies have shown that at least one-third of MDD patients who are treated with antidepressants fail to ...
Aspect Medical Systems Presents Positive Results of BRITE Major ...
Business Wire (press release), CA -
Abstracts highlighting these preliminary economic analyses will be presented at the ISPOR meeting this week as well as at the New Clinical Drug Evaluation ...ASPM
Rulings limit patients' ability to sue device firms, drugmakers
American Medical News (subscription) -
Allowing such lawsuits disrupts the system that the FDA uses to weigh the risks and benefits of new devices when evaluating their safety and effectiveness, ...
Ecstasy is the key to treating PTSD
Times Online, UK - May 3, 2008
Word, and supplies, of the new ?love drug? got out, and in the early 1980s it became popular in the fashionable clubs of Dallas, LA and London, ...
Duration of antidepressant use during pregnancy and risk of major ...
British Journal of Psychiatry (subscription), UK - Apr 30, 2008
Of all co-exposures during the first trimester (SSRIs plus new antidepressants; SSRIs plus tricyclics; tricyclics plus new antidepressants), the SSRI plus ...
Sanofi-aventis: Encouraging First-Quarter 2008 Results Further ...
Earthtimes (press release), UK - Apr 30, 2008
As expected by its new MoA, saredutant lacks side effects frequently observed with current antidepressants. This was confirmed in the INDIGO elderly study. ...SNY
Second-Generation Antipsychotics: Cost-Effectiveness, Policy ...
Psychiatric Services (subscription) - May 1, 2008
New York, Norton, 2001 Scully JH, Wilk JE: Selected characteristics and data of psychiatrists in the US, 2001?2002. Academic Psychiatry 27:247?251 ...
Federal regulators warn that an array of drugs could play a role ...
Los Angeles Times, CA - Apr 14, 2008
But a spate of recent announcements from federal health officials suggests a surprising new interpretation of suicidal fantasies and the depression they are ...

Common Ground.ca
Not getting enough sleep? It could be hazardous to your health
Common Ground.ca, Canada - Apr 28, 2008
During the tech stock boom in 1999, the Wall Street Journal ran an article entitled ?Sleep, the New Status Symbol.? The newest perk among CEOs, ...
New Abbott Kaletra(R) (lopinavir/ritonavir) Lower-Strength Tablet ...
PR Newswire UK (press release), UK - Apr 6, 2008
The US Department of Health and Human Service recommends lopinavir/ritonavir for the initial treatment of children with HIV. The new tablet formulation will ...ABT
Source: Google News

[PDF] The emperor?s new drugs: An analysis of antidepressant medication data submitted to the US Food and … -
I Kirsch, TJ Moore, A Scoboria, SS Nicholls - Prevention & Treatment, 2002 - astimhelp.net
... The Emperor's New Drugs: An Analysis of ... assumption is warranted, then current
antidepressants may be ... to determine the effectiveness of antidepressant medication ...

Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical … -
A Khan, SR Khan, RM Leventhal, WA Brown - The International Journal of Neuropsychopharmacology, 2001 - Cambridge Univ Press
... over the use of placebo in antidepressant clinical trials. ... Two new antidepressants
have been introduced to the USA ... FDA) database for these two antidepressants. ...

Placebo-Controlled Trials and Active-Control Trials in the Evaluation of New Treatments. Part 2: … -
SS Ellenberg, R Temple - Annals of Internal Medicine, 2000 - annals.highwire.org
... all controlled trials of all antidepressants approved for ... active-control studies
if acute antidepressant effects were ... typical clinical trial of new agents is ...

Are placebo controls necessary to test new antidepressants and anxiolytics? -
A Khan, S Khan, WA Brown - The International Journal of Neuropsychopharmacology, 2002 - Cambridge Univ Press
... high likelihood that ineffective anti- depressants and anxiolytics ... 2002 Key words:
Antidepressants, anxiolytics, clinical ... effectiveness of a new method should ...

New antidepressants and the cytochrome P450 system: focus on venlafaxine, nefazodone, and … -
JR Owen, CB Nemeroff - Depress Anxiety, 1998 - ncbi.nlm.nih.gov
Click here to read New antidepressants and the ... the addition of the latest antidepressant
medications, the ... with these novel antidepressants, particularly in ...

Pregnancy Outcome Following Maternal Use of the New Selective Serotonin Reuptake Inhibitors A … -
NA Kulin, A Pastuszak, SR Sage, B Schick-Boschetto … - JAMA, 1998 - Am Med Assoc
... Outcomes of Prenatal Antidepressant Exposure Simon et al. ... Following Exposure to
Tricyclic Antidepressants or Fluoxetine ... Use of New SSRIs in Pregnancy Appears ...

Antidepressants and Suicide Risk in the United States, 1985-1999 -
MF Grunebaum, SP Ellis, S Li, MA Oquendo, JJ Mann - Journal of Clinical Psychiatry, 2004 - excalibur.cpmc.columbia.edu
... 1051 Riverside Dr., Box 42, New York, NY ... The non-tricyclic antidepressants bupropion
and fluox- etine ... and other illnesses for which anti- depressants have been ...

[PDF] Suicide Risk During Antidepressant Treatment -
GE Simon, J Savarino, B Operskalski, PS Wang - American Journal of Psychiatry, 2006 - geographeclinic.com.au
... observed in our sample, a new study comparing ... increase in suicide risk with
antidepressants was the ... in adolescents en- rolled in antidepressant clinical trials ...
-

Assessing the economic value of a new antidepressant. A willingness-to-pay approach.
BJ O'Brien, S Novosel, G Torrance, D Streiner - Pharmacoeconomics, 1995 - ncbi.nlm.nih.gov
... study assesses the value of a new antidepressant, moclobemide, relative to that
of tricyclic antidepressants (TCAs), which ... 7 adverse effects, the risk of which ...

Use of selective serotonin-reuptake inhibitors or tricyclic antidepressants and risk of hip … -
B Liu, G Anderson, N Mittmann, T To, T Axcell, N … - Lancet, 1998 - pt.wkhealth.com
... is not associated with duration of antidepressant therapy, premenopausal ... use, for
all types of antidepressants Table 3 ... fracture was higher for new current users ...

Source: Google Scholar

Antidepressants should list new risks-US FDA

WASHINGTON - Information about risks to newborns and migraine sufferers linked to some of the world's most widely used antidepressants should be added to the drug labels, the U.S. Food and Drug Administration said on Wednesday.

The FDA warned that taking antidepressants known as SSRIs -- including Prozac and Zoloft -- or certain SNRIs in combination with migraine drugs known as triptans could result in a life-threatening condition called serotonin syndrome. It also warned consumers about the risk of a fatal lung condition in newborns whose mothers took SSRIs during pregnancy. The agency added it was seeking more information about persistent pulmonary hypertension in newborns following exposure to these drugs. The agency asked drug makers to list the potential risks on their drug labels.

SSRIs, or selective serotonin reuptake inhibitors, include GlaxoSmithKline Plc's Paxil, Eli Lilly and Co's Prozac, Pfizer Inc's Zoloft and Symbyax, Forest Laboratories Inc's Celexa and Lexapro, and Solvay Pharmaceutical's Luvox, which is also sold generically as fluvoxamine.

The SNRIs, or selective serotonin/norepinephrine reuptake inhibitors, cited by the FDA are Lilly's drug Cymbalta and Wyeth's Effexor.

Triptan migraine drugs include Glaxo's Imitrex and Amerge, Johnson & Johnson's Axert, Endo Pharmaceutical's Frova, Merck and Co Inc's Maxalt, Pfizer's Relpax and AstraZeneca Plc's Zomig.

The agency advised patients to talk to their doctors about deciding whether to continue taking the drugs.

Vaccination key to controlling bird flu: UK report

LONDON - Britain should opt to vaccinate poultry rather than slaughter flocks in order to tackle the threat of the lethal H5N1 strain of bird flu, according to a report issued on Wednesday by an organic research centre.

"Bio-security measures are an essential element of any strategy but the slaughter element is as outdated as British imperialism," the Elm Farm Research Centre said in a report. "A truly rational government would acknowledge that preventive vaccination is the most effective method of combating avian influenza in the modern world and would now be preparing to vaccinate all outdoor and organic flocks," the report added.

Britain's farm ministry has raised concerns about bird flu vaccines for poultry, arguing they can mask the effects of the disease and make it more difficult to tackle its spread among the poultry population.

The Soil Association, Britain's organic certification body, distanced itself from the report, issuing a statement supporting "strategic" but "not preventative" use of vaccination. It backs vaccination only under limited circumstances, such as if culling fails to control the disease or if the virus becomes endemic in Britain's wild birds. Last week Britain's farm ministry issued a tender for 10 million doses of bird flu vaccine while stating its policy had not changed and it would not vaccinate poultry in advance of a bird flu outbreak. The ministry said the move was part of "sensible contingency planning in the light of uncertainties relating to the future spread and nature of the virus."

Britain currently plans to house all birds for a limited period in areas where the bird flu virus has been found and slaughter affected flocks. If the disease became endemic in an area, flocks could be kept indoors indefinitely.

This is an apparent willingness amongst politicians and officials to ignore animal welfare by permanently housing outdoor birds thereby destroying the free-range and organic markets in an attempt to maintain an outmoded disease free status for the nation," the report said.

The European Union has allowed Europe's two largest poultry producers, France and the Netherlands, to vaccinate hens, ducks and geese against H5N1. Very few producers have, however, taken up the option.

There has been only one confirmed case of the H5N1 strain in Britain in a wild swan, found dead in early April. There have been no cases yet in domestic poultry.

H5N1 has, however, spread rapidly since late 2003 from Asia to Europe and Africa with outbreaks confirmed in more than 48 countries and territories, according to data from the World Organisation of Animal Health.

 

Common bacteria linked to circulatory disease

NEW YORK (Reuters Health) - Infection by Helicobacter pylori, a bacteria associated with peptic ulcers and gastric cancer, also appears to increase the risk of diseases of the circulation, also referred to as "vascular disease," according to an analysis by Italian researchers.

Lead investigator Dr. Vincenzo Pasceri told Reuters Health that "clinical studies on the association between H. pylori and vascular diseases have produced conflicting results. While some studies have shown a significant association, these results have not been confirmed in others.

In the June issue of the American Heart Journal, Pasceri of San Filippo Neri Hospital, Rome, and colleagues report on their review of 17 studies that looked at the role of cytotoxin-associated gene A (CagA)-positive strains of H. pylori in patients with vascular disease of the heart and brain. More than 6,000 patients were included.

Overall, 13 studies found a statistically significant relationship between positive strains of CagA and heart disease. However, this relationship was not seen in CagA-negative strains. In 4 other studies, there was a significant association between brain disease and CagA-positive strains of H. pylori and, again, no association with negative strains.Infection with CagA-positive H. pylori strains is associated with a modest but significant risk of vascular heart disease, continued Dr. Pasceri.

"Even a modest increase in cardiovascular risk may have great clinical importance," he concluded, "since chronic infection by virulent strains of H. pylori may be present in 20 percent to 40 percent of the population in Western countries."

 
 
 
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