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Recent News and Articles on the Keywords: brain surgery + severe ocd + brain  Related to the article below (Last Update: 5/5/2008)

Deep Brain Stimulation Shows Promise in Severe, Refractory Depression
Medscape (subscription) - Apr 30, 2008
"We noticed in our OCD patients, many of whom also had depression, that their mood substantially improved with deep brain stimulation. ...
Deep Brain Stimulation May Offer Hope for Select Patients with ...
Newswise (press release) - Apr 28, 2008
Results of the OCD study, Deep Brain Stimulation of the Ventral Internal Capsule/Ventral Striatum for Obsessive-Compulsive Disorder (OCD): World-Wide ...

Business Wire (press release)
Clinical Data on the Use of Medtronic?s Deep Brain Stimulation ...
Business Wire (press release), CA - Apr 28, 2008
MINNEAPOLIS--(BUSINESS WIRE)--Medtronic, Inc. (NYSE:MDT) today announced that data on the use of its deep brain stimulation (DBS) system for severe, ...MDT - CLDA
Treatment-Resistant Depression Responds to Deep-Brain Stimulation ...
DG News - May 1, 2008
[Presentation title: Deep Brain Stimulation (DBS) for the Treatment of Intractable Major Depression: Long-Term Outcomes From a Prospective Multi-Center ...
Medtronic brain device strikes positive note
Pioneer Press, MN - Apr 28, 2008
Because implanting a device involves brain surgery, doctors are testing deep brain stimulation only on patients who have the most severe cases and have not ...MDT
Source: Google News

Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: psychopathological … -
L Gabriels, P Cosyns, B Nuttin, H Demeulemeester, … - Acta Psychiatrica Scandinavica, 2003 - Blackwell Synergy
... Compared with capsulotomy, brain tissue destruction is substantially ... up to 10 years
after surgery (38, 39). ... role in the treatment of severe, longstanding and ...

Deep brain stimulation for refractory obsessive-compulsive disorder -
JL Abelson, GC Curtis, O Sagher, RC Albucher, M … - Biological Psychiatry, 2005 - Elsevier
... In severe, refractory cases, stereotaxically applied neurosurgical lesions ... Studies
of deep brain stimulation (DBS) in ... on the day of surgery, targeting visually ...

Neurosurgical treatment of severe obsessive-compulsive disorder associated with Tourette's syndrome -
R Kurlan, J Kersun, HT Ballantine, ED Caine - Movement Disorders, 1990 - doi.wiley.com
... Recent brain im- aging studies using positron emission ... TS appears responsive to ablative
surgery involving cingulate ... with TS complicated by severe OCD that has ...

The nucleus accumbens: a target for deep brain stimulation in obsessive?compulsive-and anxiety- … -
V Sturm, D Lenartz, A Koulousakis, H Treuer, K … - Journal of Chemical Neuroanatomy, 2003 - Elsevier
... Electrical deep brain stimulation (DBS) at high-frequencies ... 3. Implications for
psychiatric surgery. ... anterior capsulotomy as treatment for severe OCD and anxiety ...

Case Study: Obsessive-Compulsive Disorder after Severe Traumatic Brain Injury in an Adolescent. -
JE MAX, MBB CH, WL SMITH JR, SD LINDGREN, DA ROBIN … - Journal of the American Academy of Child & Adolescent …, 1995 - jaacap.com
... the evolution and resolution of OCD in a pubertal adolescent after severe TBI ... we
are not aware of such an effect after surgery not involving brain tissue or ...

Deep Brain Stimulation of the Anterior Internal Capsule for the Treatment of Tourette Syndrome: … -
AW Flaherty, ZM Williams, R Amirnovin, E Kasper, … - Neurosurgery, 2005 - neurosurgery-online.com
... DBS surgery is being increasingly applied for indications ... but associated pathological
condition, severe OCD (1), in ... JM, Kennedy SH: Deep brain stimulation for ...

[PDF] Mechanisms and the current state of deep brain stimulation in neuropsychiatry -
BD Greenberg, AR Rezai - CNS Spectr, 2003 - cnsspectrums.com
... safety and efficacy of DBS surgery for intractable ... DEEP BRAIN STIMULATION FOR
INTRACTABLE OBSESSIVE-COMPULSIVE ... who also had moderately severe OCD were reported ...
-

Surgery in Tourette syndrome -
Y Temel, V Visser-Vandewalle - Movement Disorders, 2004 - doi.wiley.com
... patient character- istics, medical history, surgery, outcome and ... age of 9 years,
with severe obsessive?compulsive ... could be associated with brain damage from ...

Deep brain stimulation for psychiatric disorders -
B Nuttin, J Gybels, P Cosyns, L Gabriels, B … - Neurosurgery Clinics of North America, 2003 - Elsevier
... in the use of deep brain stimulation (DBS ... effects in patients with severe
obsessive-compulsive disorder (OCD) that is ... 3. Candidates for DBS surgery should ...

Three-Year Outcomes in Deep Brain Stimulation for Highly Resistant Obsessive?Compulsive Disorder -
BD Greenberg, DA Malone, GM Friehs, AR Rezai, CS … - Neuropsychopharmacology, 2006 - nature.com
... Severe, treatment-resistant obsessive?compulsive disorder (OCD ... previously limited
to ablative surgery, such as ... have suggested that deep brain stimulation (DBS ...

Source: Google Scholar

Brain surgery helps with severe OCD, but has risks

NEW YORK (Reuters Health) - Capsulotomy -- a neurosurgical operation that involves severing nerve fibers in the central part of the brain -- can be an effective treatment for the most severe forms of obsessive-compulsive disorder (OCD) and anxiety, but patients often experience a major personality change, including persistent apathy and sexual disinhibition.

The findings, which were discussed this week at the Euroscience Open Forum in Munich, Germany, are based on a study of 51 patients who were treated at the Karolinska Institute in Sweden. Roughly two patients a year have undergone capsulotomy for OCD/anxiety at the Institute since the procedure was developed there in the 1950s.

"The frequency of adverse effects was higher than expected," Dr. Christian Ruck of the Karolinska Institute said in a statement. "Neurosurgery for mental disorders is currently gaining a lot of attention in the professional community with new ongoing trials in several countries and I think our results are another reason for caution", stated Ruck.

After undergoing capsulotomy, patients in the current study were followed for up to 23 years with a variety of measures, including questionnaires, interviews, neuropsychological testing, and brain imaging.

While the operation often led to resolution of the most severe OCD symptoms, over a third of patients developed apathy and had problems planning and executing activities. Other serious side effects included epilepsy, sexual disinhibition, and urinary incontinence.

The frequency of side effects reported in the present study, the largest to date to examine the long-term effects of capsulotomy, differs from what has been reported at other centers, Ruck noted. "The other studies found very few risks with the surgery."

As to the reason for the different outcomes, Ruck said it may relate to the length of follow-up. "There are almost no studies with long-term follow-up. I think it has just been assumed that the procedure is safe, so people have stopped doing proper follow-up."

"Whether capsulotomy is a good treatment for severe OCD and anxiety depends on who you ask," Ruck told Reuters Health. Most doctors "consider the side effects experienced by the patients to be pretty severe." The patients themselves, however, seemed glad to trade their OCD symptoms for the apathy and other side effects experienced, he added.

In light of the current findings, Ruck said his initial "enthusiasm for capsulotomy as a treatment for severe OCD has faded."

The good news is that in recent years some effective psychological methods of treating severe OCD and anxiety have appeared, including intensive cognitive behavioral therapy, he added.

 

Language a Widening Barrier to Health Care

 WEDNESDAY, July 19 (HealthDay News) -- One of the biggest barriers to high-quality health care for millions of U.S. residents has nothing to do with medicine.

It has to do with language.

"We're looking at 50 million people in the U.S., 19 percent of the population, who speak a language other than English at home and 22 million who have limited English proficiency, so that's a lot of people," said Dr. Glenn Flores, director of the Center for the Advancement of Underserved Children, and a professor of pediatrics, epidemiology and health policy at the Medical College of Wisconsin in Milwaukee.

And the number is growing, added Flores, who is author of a perspective article in the July 20 issue of the New England Journal of Medicine that outlines the issues and possible solutions.

Between 1990 and 2000, the number of Americans speaking a language other than English at home grew by 15.1 million (a 47 percent increase) and the number with limited English proficiency grew by 7.3 million (a 53 percent increase).

Patients who face language barriers have difficulty accessing care, receive fewer preventive services, and are less likely to follow medication directions. For example, asthmatic children with language barriers are more likely to end up intubated in intensive care.

"Patients who do not have the opportunity to have a culturally and linguistically competent physician often don't get as good care," confirmed Dr. Robert Schwartz, chairman of family medicine and community health at the University of Miami Miller School of Medicine. "It's a critical issue to be able to speak to a patient."

Schwartz's department serves a predominantly Hispanic part of Miami. And in Miami, according to the journal article, 75 percent of residents speak a language other than English at home.

Examples cited by Flores range from the near-comic to the tragic.

There was, for instance, the interpreter who mistranslated a nurse practitioner's instructions and told a mother to put oral antibiotics into her 7-year-old daughter's ear.

In another example, the mistranslation of a single word resulted in preventable quadriplegia. The patient, an 18-year-old male, said in Spanish that he felt nauseated before collapsing. A non-Spanish speaking paramedic mistook the word to mean "intoxicated," and the patient spent more than 36 hours being worked up for a drug overdose. The delay resulted in the rupture of a brain aneurysm. The case was settled for $71 million.

And one Spanish-speaking woman told a hospital resident that her 2-year-old daughter had "hit herself" falling off her tricycle. The resident misinterpreted the statement to mean abuse and contacted the appropriate authorities, who had the mother sign over custody of both her children.

The language issues are most pronounced in the emergency room and in psychiatric settings. One study found that no interpreter was used in 46 percent of emergency-room cases involving patients with limited English proficiency.

Psychiatric patients who have language barriers are more likely to receive a diagnosis of severe psychopathology, and are also more likely to leave the hospital against doctors' orders.

What can be done?

"We need to keep making the case based on the evidence, which is that you see a lot of adverse consequences," Flores said. "There's a long laundry list we've accumulated and all of this is adding up to suboptimal quality of care, excessive costs, lower patient satisfaction, medical errors, and even morbidity and death. We can do a better job."

Currently, only 13 states provide third-party reimbursement for interpreter services. Unfortunately, most of the states containing the largest numbers of patients with limited English proficiency have not followed suit, sometimes citing concerns about costs.

There is legislation in the works, including a bill in California that would prohibit state-funded organizations from using children younger than 15 years of age as medical interpreters. But more needs to be done, Flores said. One government report estimated that it would only cost, on average, $4.04 more per physician visit to provide all U.S. patients who need them with language services.

In the meantime, individual institutions do what they can. Maimonides Medical Center in New York City, for example, has about 80 languages spoken there, including Gujarati, spoken on the west coast of India, and Zapotec, a native Mexican-Indian dialect.

"About five years ago, we put up our patient bill of rights in 10 different languages and that barely scratches the surface," said CEO and President Pamela Brier.

The center relies on a network of interpreters from the existing staff and volunteers, including people who were doctors in their own country and are hoping to get into a residency program. About four years ago, the hospital hired enough people to have round-the-clock coverage in Mandarin, Cantonese and Russian.

"For all we do, we have not nailed it," Brier said. "It's going to be a life's work."

More information

Some recommendations for setting up interpreter programs in hospitals can be found at Universal Health Care.

 
 
 
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