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Recent News and Articles on the Keywords: may help + lung cancer + nicotine  Related to the article below (Last Update: 5/5/2008)

Discovery May Help Explain Smoking-pancreatic Cancer Link
Science Daily (press release) - Apr 14, 2008
ScienceDaily (Apr. 14, 2008) ? If lung cancer and heart disease aren't bad enough, cigarette smokers are also at higher risk for developing, ...
Middle East terrorism: Now fueled by nicotine
WalletPop, VA -
by Bruce Watson May 5th 2008 @ 4:00PM Emphysema, heart disease, lung cancer, necrosis, crib death, bad smells...smoking has been accused of causing an ...
Certain genes raise addiction, lung cancer risk
Gather.com, MA - Apr 15, 2008
If you have been unable to quit smoking, realizing that your nicotine addiction is not a weakness may help you take the necessary steps to stop. ...
Tobacco and health: The smoking gun
Telegraph.co.uk, United Kingdom - Apr 25, 2008
More than 25pc of Swedish men use snus regularly while less than 15pc smoke. Lung cancer rates among Swedish men are claimed to be the lowest in the world. ...
Smokers must be targets of more than a tax grab
The Guardian, Canada - May 3, 2008
She?d become addicted to nicotine as a young teenager. She was now in her mid-60s. Even though her life may have depended on it, she knew giving up ...
7 Questions Adolescents Have About Tobacco
U.S. News & World Report, DC - Apr 25, 2008
?Compiled by Sarah Baldauf faris - Manhattan jr.high - Both of my parents smoke am I at risk of lung cancer? Larry Stanford - That's a very good question. ...
Age Related Macular Degeneration
Senior Times, FL - May 2, 2008
... may also reduce advanced AMD incidence. If you are a smoker with AMD, let your doctor know because beta carotene supplements increase lung cancer risk ...
The rule in sports: Smoke 'em if you got 'em
ESPN - Apr 28, 2008
Cal Ripken Sr.'s jerseys were similarly accessorized (which, unfortunately, might help explain why he died of lung cancer at the age of 63), and a game-worn ...
Splint often relieves pain of carpal tunnel syndrome
SouthCoastToday.com, MA - Apr 16, 2008
Nicotine gum would be a substitute. It can help him gradually withdraw from his addiction. Even the nicotine skin patch would be helpful. Readers may write ...
Program to help smokers butt out
Wellington Times, Australia - Apr 23, 2008
Diseases and health problems such as lung cancer, Chronic Obstructive Pulmonary Disease, emphysema and heart and blood vessel disease to name a few, ...
Source: Google News

Nicotine Metabolism and Intake in Black and White Smokers -
EJ Perez-Stable, B Herrera, P Jacob, NL Benowitz - JAMA, 1998 - Am Med Assoc
... of nicotine is highly correlated to exposure to tar and oxidant gases, the latter
observation may help explain the higher smoking-related risks of lung cancer ...

A Functional Role for Nicotine in Bcl2 Phosphorylation and Suppression of Apoptosis -
H Mai, WS May, F Gao, Z Jin, X Deng - Journal of Biological Chemistry, 2003 - ASBMB
... 8). These findings may help to develop a novel ... Nicotine induces phospholipase C
activation that triggers PKC/ERK1 ... for providing NCI-H82 human lung cancer cells. ...

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human … -
KA West, J Brognard, AS Clark, IR Linnoila, X Yang … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig
... by Airway Bronchial Epithelial Cells Endocrinology, May 1, 2004 ... Home page JD Minna
Nicotine exposure and bronchial ... in the pathogenesis of lung cancer J. Clin. ...

Do Calcium Channel Blockers Increase the Risk of Cancer? -
M Pahor, JM Guralnik, ME Salive, MC Corti, P … - nature.com
... if confirmed by other studies, may help to explain ... 38 and, therefore, the pharmacologic
action may differ among ... suppresses apoptosis in human lung cancer cells ...

Aiding reduction of smoking with nicotine replacement medications: hope for the recalcitrant smoker? -
KO Fagerstrom, R Tejding, A Westin, E Lunell - British Medical Journal, 1997 - tobaccocontrol.bmj.com
... suggesting that subjects were titrating nicotine to their ... A smoking reduction procedure
may help the very ... Effect of Smoking Reduction on Lung Cancer Risk JAMA ...

Nicotine stimulates a serotonergic autocrine loop in human small-cell lung carcinoma -
MG Cattaneo - Cancer Research, 1993 - AACR
... WKK Wu, JC Luo, and CH Cho Nicotine Promoted Colon ... Sci., May 13, 1998; 841(1): 606 -
624 ... abrogates the tumorigenicity of human small cell lung cancer cell lines ...

Exposure to secondhand smoke and excess lung cancer mortality risk among workers in the" 5 B's": … -
M Siegel, M Skeer - British Medical Journal, 2003 - tobaccocontrol.bmj.com
... in the 5 B?s may help promote not ... levels (and consequently, in the lung cancer mortality
risk ... to the lowest and highest mean nicotine concentrations reported ...

… of Gastrin-Releasing Peptide Receptor: Relationship to Smoking History and Risk of Lung Cancer -
SP Shriver, HA Bourdeau, CT Gubish, DL Tirpak, ALG … - jnci, 2000 - jnci.oxfordjournals.org
... pattern in PBLs, which are also exposed to nicotine from cigarette ... in the detection
of airway cells predisposed to lung cancer and may help to identify ...

Effectiveness of smoking cessation self-help materials in a lung cancer screening population -
MM Clark, LS Cox, JR Jett, CA Patten, DR Schroeder … - Lung Cancer, 2004 - Elsevier
... Alternately, there may be a potential for current or ... of standard written self-help
materials for ... smoking abstinence rates in a lung cancer screening population ...

Tobacco Smoke Carcinogens and Lung Cancer -
SS Hecht - jnci, 1999 - jnci.oxfordjournals.org
... which suggests that poor detoxification potential may be one ... incidence and mortality
rates of lung cancer in blacks ... to result from higher nicotine intake per ...

Source: Google Scholar

Nicotine May Help Spur Lung Cancer

  FRIDAY, July 21 (HealthDay News) -- While the nicotine in tobacco and in nicotine-replacement patches and gums doesn't cause lung cancer, it may help it along, a new study finds.

"Nicotine can promote the growth of new blood vessels and new cells -- two things that are correlated with the progression of cancer -- and our study shows how this actually happens," said study co-author Srikumar P. Chellappan, an associate professor in the Drug Discovery Program with the H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, in Tampa.

The finding raises questions about the use by lung cancer patients of nicotine-containing interventions aimed at helping smokers quit, such as popular patches and gums.

Chellappan's team identified a key binding process taking place between nicotine and receptors found on cells lining the lung's air passages, and in lung cancer cells themselves. The bond between nicotine and these receptors provokes further lung cancer cell proliferation, the researchers report in the August issue of the Journal of Clinical Investigation.

The Florida group conducted their lab work on cancer cells taken from patients afflicted with non-small cell lung cancer (NSCLS).

According to the American Cancer Society, lung cancer accounts for 13 percent of all new cancers and is the leading cancer killer of American men and women. Non-small cell cancers comprise 85 percent of the nearly 175,000 new cases of lung cancer diagnosed in the United States each year.

But while tobacco smoke is the direct cause of eight out of 10 lung malignancies, nicotine -- the addictive chemical in tobacco -- does not have cancer-causing properties. The role, if any, of nicotine in lung cancer has long been the subject of debate.

In previous work, Chellapan found that nicotine exposure among lung cancer patients did appear to undermine chemotherapy's effectiveness in killing off cancer cells. Because so many patients use nicotine patches or gums to help them quit, this raise the troubling notion that these interventions might actually help encourage the disease.In this study, Chellappan's focused on NSCLS cells and adjacent cells from the lung's air passages also known as bronchial cells. They exposed both cell types to nicotine in the test tube. The amount of nicotine used was the equivalent to what would typically be present in the bloodstream of a patient who smokes one pack of cigarettes a day.

In addition to binding with what are known as nicotinic acetylcholine receptors, the nicotine appeared to help create signaling pathways that promoted the cancer cell growth cycle. This growth activated and recruited other cell machinery known to stimulate tumor growth.

The researchers concluded that, in the test-tube setting, nicotine appears to go beyond simply protecting cancer cells as had been previously observed. Instead, it appears to promote cancer-cell proliferation and tumor progression.

"We found that a normal amount of nicotine that is typically present in the blood of smokers can really induce a proliferation of cancer cells, and we have identified some proteins in the cell that facilitate this proliferation," said Chellappan.

"So, smokers should be staying away from all products that contain nicotine," he cautioned. "Not just cigarettes -- anything. I can not say that this is just about smoking. This is about exposure to any nicotine. Even a patch to help quit smoking may not be the best idea."

Nevertheless, one expert is still on the fence when it comes to the risks and benefits for lung cancer patients in using nicotine-replacement therapies.

"You can't necessarily say whether nicotine-replacement therapy is a good or bad idea," said Dr. Norman H. Edelman, chief medical officer with the American Lung Association.

"My guess is that it's a good idea to engage in smoking cessation," he said. "Smoking cessation is a much healthier way to go rather than avoiding the nicotine in smoking-cessation therapies based on the theoretical risk shown in test tubes that nicotine can promote tumors."

Edelman emphasized, however, that the current study is "an important biologic finding" that will need to be followed up with research in animals and ultimately humans.

Two other major groups agreed. The U.S. National Cancer Institute's Web site states that "any potential risks of short-term use of nicotine-replacement therapy to stop smoking are far outweighed by the significant and known benefits that accrue to patients who stop smoking."

And the American Cancer Society's Web site notes that "numerous studies have shown that these products are safe and effective in helping smokers quit." Society experts also point out that the use of nicotine-replacement products, alongside in-person and phone counseling, can double a smoker's chances of successfully quitting.

Health Highlights: July 21, 2006

  Here are some of the latest health and medical news developments, compiled by the editors of HealthDay:

HHS Chief's Foundation Got Tax Breaks, Gave Little to Charity: Report

A charitable foundation set up by U.S. Health and Human Services Secretary Mike Leavitt and his relatives enabled them to claim millions of dollars in tax deductions while providing little to charity, The Washington Post reported Friday.

The foundation was set up in 2000 with almost $9 million from Leavitt family assets. Much of that money went into investments or loans to the family's business interests and real estate holdings.

Less than 1 percent of the Leavitt Foundation's assets were donated to charity in 2002, 2003 and 2004, the Post reported. And since 2000, Mike Leavitt alone has claimed about $1.2 million in tax write-offs.

"They're basically sitting on all this money, getting a charitable write-off and doing nothing with it," said Rick Cohen, executive director of the National Committee for Responsive Philanthropy.

The Post had asked Cohen to review the Leavitt Foundation's records and tax returns.

Christina Pearson, an HHS spokeswoman, said the foundation's activities are 'totally legal and proper.'

-----

Senators Peck at U.S. Bird Flu Testing Program

The voluntary nature of the U.S. Agriculture Department's bird flu testing program threatens the U.S. poultry industry, a group of U.S. Senators (five Democrats and one Republican) wrote in a letter to Agriculture Secretary Mike Johanns.

The letter cited a federal audit that found that the U.S. government does not have a comprehensive plan for bird flu testing and monitoring in the commercial poultry industry, the Associated Press reported. A plan will be in place by October, says the Agriculture Department.

"It is surprising that USDA does not have a program that monitors and collects data on what testing is taking place," the senators wrote in the letter. "We are deeply concerned that the agency has waited until this year to begin to develop a comprehensive surveillance plan for avian influenza, which will not be complete until October."

They contend that USDA is relying too heavily on states and noted that many states don't have enough staff help to coordinate a bird flu surveillance program, the AP reported.

-----

More U.S. Doctors Using Electronic Medical Records

In 2005, 23.9 percent of office-based American doctors were using partial or full electronic medical records (EMRs), an increase of 31 percent from the number of doctors using them in 2001, according to a U.S. Centers for Disease Control and Prevention report released Friday.

The survey of about 1,900 doctors found that those in the Midwest (26.9 percent) and West (33.4 percent) were more likely to use EMRs than those in the Northeast (14.4 percent).

Doctors in metropolitan areas (24.8 percent) were more likely to use EMRs than those in non-metropolitan areas (16.9 percent).

Solo practitioners -- who account for a third of doctors but for two-thirds of medical practices -- were least likely to used EMRs.

Despite increased use, the report noted that only 9.3 percent of doctors used EMRs with all four of the basic functions considered necessary for a complete EMR system. The four functions are: computerized orders for prescriptions, computerized orders for tests, reporting of test results, and physician notes).

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Study Finds High Lead Levels in Paints

Some paints used in China, India and Malaysia have lead levels that are much higher than the legal limit in the United States and pose a serious health hazard to children, says a University of Cincinnati study in the September issue of the journal Environmental Research.

These dangerously-high lead levels pose a threat to children around the world because the paints may be used on products that are shipped to other countries. Lead can cause brain damage and other health problems in children.

The researchers sampled 80 paints in four countries. They found that about 50 percent of paint sold in China, India and Malaysia had lead levels 30 times greater than the U.S. limit of 600 parts per million, and some of the paints had levels as much as 300 times the U.S. limit, Agence France Presse reported.

About 10 percent of paint sold in Singapore had lead levels higher than the U.S. limit.

Previous research found high lead levels in paint sold in Indonesia, Peru and the Seychelles.

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FDA Scientists Cite Agency Shortcomings in Poll

The U.S. Food and Drug Administration seems to care more about speeding new drugs to market than ensuring medication safety, more than one-third (37 percent) of the agency's scientists said in a new survey.

The poll, conducted by the Union of Concerned Scientists, also found that 39 percent of the 997 FDA scientists surveyed said the agency wasn't "acting effectively to protect public health," the Baltimore Sun reported Friday. Another 32 percent said the FDA didn't always release complete and accurate information to the public, the newspaper reported.

An FDA spokeswoman called the survey unscientific and "a counterproductive exercise based on leading questions and innuendo."

Senate Finance Committee Chairman Charles Grassley (R-Iowa) issued a statement saying the FDA was in need of "a major overhaul and a culture change at the highest levels," the Sun reported.

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U.S. Warns of Unapproved Lyme Disease Remedy

Citing at least one death from an unapproved remedy for Lyme disease, the U.S. Food and Drug Administration warned doctors and consumers Friday against use of the product, called "bismacine," and also known as chromacine.

The agency issued a statement saying the injected product is not FDA-approved to treat any condition whatsoever. The product contains high amounts of bismuth, a heavy metal used in some pill remedies to treat bacteria that cause stomach ulcers. But the agency said the substance is not approved to be injected.

Poisoning from bismuth can lead to cardiovascular collapse and kidney failure, the FDA warned.

In April, one person died after using the product, and at least one other person has been hospitalized after receiving bismacine, the agency said. The product isn't considered a pharmaceutical and has been dispensed by individual druggists, alternative health practitioners, or by people claiming to be medical doctors, the FDA added.

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Drugmakers Given OK to Color Pills

Drugmakers have been granted U.S. Food and Drug Administration approval to begin using pigments to color pills, tablets, and liquids to brighten their appeal, the Associated Press reported.

The pearlescent pigments, similar to those that give cosmetics a pearly sheen, can produce metallic, satiny, and shimmery finishes, the wire service said. The FDA approved their use some eight years after a New Jersey firm first petitioned the agency, the AP added.

Similar pigments are used in lipsticks, eye shadows, nail polishes and automobile paints, the wire service said. Four years ago, the FDA approved their use in coloring contact lenses.

The new rule specifies that the pigments cannot comprise more than 3 percent of the drug's weight, the AP noted.

 
 
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