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Recent News and Articles on the Keywords: national institute + halt disease + disease  Related to the article below (Last Update: 5/5/2008)

DNA tweak no good for diabetics
Science News - 38 minutes ago
The blood vessels can lead to tears in the eye tissue or detachment of the retina in the most severe form of the disease, known as proliferative diabetic ...
Anti-US Beef Vigils Feared to Escalate
동아일보, South Korea -
The Korea Alliance for Progressive Movement posted a guideline for the ?fight against mad cow disease? on its homepage Sunday. The guideline said, ?Let us ...

Natural News.com
Deadly Animal Virus May Soon Come to US Mainland
Natural News.com, AZ - May 2, 2008
Herds would be quarantined, and controlled slaughter would begin to help halt the spread of the disease. Although the British outbreak indicated that the ...
Scientists claim videos are proof of Alzheimer's breakthrough
Independent, UK - Apr 11, 2008
In 2005 their NHS use was restricted to the moderate stage of the disease ? as opposed to early or late stages ? by the National Institute for Clinical ...
Meningitis crisis grips Meghalaya
Sify, India - Apr 20, 2008
... were unaware of the disease, say health staff in the districts. A central medical team from the National Institute for Communicable Diseases visited the ...
USDA isn't on board with beef industry's downer cow ban
Press-Enterprise, CA - Apr 29, 2008
Downers are considered more likely to have mad cow disease and other illnesses, and therefore pose a greater threat to people who eat them. ...
Stem Cell Research Leads To Potential New Therapy For Rare Blood ...
Science Daily (press release) - Apr 7, 2008
"As a clinician, I asked myself who is going to get this disease, and what can we do to stop its progression, instead of waiting until it evolves into a ...
Declining US life expectancy: a consequence of widening inequality
World Socialist Web Site, MI - Apr 23, 2008
Rates for fatal staphylococcus infections, autism and Alzheimer?s disease also continue to increase, in the face of declining medical research funding and ...
Family fights nervous system disorder
Hamilton Journal News (subscription), OH - Apr 22, 2008
Grandchildren Courtney Johnson, 10, and Noah Johnson, 7, of Georgetown were diagnosed last year with Batten Disease, an inherited disorder of the nervous ...
Appeal on Bisons? Behalf in Montana
New York Times, United States - Apr 10, 2008
Since last fall, 1615 bison seeking food at lower elevations outside the park have been killed or removed, under a state-federal livestock disease ...
Source: Google News

Neuroprotective agents for clinical trials in Parkinson's disease A systematic assessment -
BM Ravina, SC Fagan, RG Hart, CA Hovinga, DD … - Neurology, 2003 - AAN Enterprises
... Interventions that can slow or halt the progression ... the primary aim of slowing disease
progression in ... for testing in upcoming National Institute of Neurologic ...

Fabry Disease, an Under-Recognized Multisystemic Disorder: Expert Recommendations for Diagnosis, … -
RJ Desnick, R Brady, J Barranger, AJ Collins, DP … - Annals of Internal Medicine, 2003 - annals.highwire.org
... goal is to both halt disease progression and ... Lysosomal Storage Disease Network Web
site: http ... National Institute of Neurological Disorders and Stroke National ...

[PDF] … of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease -
JD Harper, SS Wong, CM Lieber, PT Lansbury Jr - Biochemistry, 1999 - doe-mbi.ucla.edu
... too late a stage could accelerate disease by causing ... the pathogenic species to either
halt further aggregation ... CML and PTL from the National Institute on Aging ...
-

NEWS: Is Apoptosis Key in Alzheimer's Disease? -
M Barinaga - Science, 1998 - sciencemag.org
... from Luciano D'Adamio and his colleagues at the National Institute of Allergy ... doubt
that blocking it will slow or halt the progress of the disease. ...

Clinical Features of and Recent Advances in Therapy for Fabry Disease -
RO Brady, R Schiffmann - JAMA, 2000 - Am Med Assoc
... disease is expected to halt the deterioration ... showed promise in patients with Gaucher
disease. ... Metabolic Neurology Branch, National Institute of Neurological ...

Hepatitis C: The clinical spectrum of disease -
JH Hoofnagle - Hepatology, 1997 - doi.wiley.com
... of Digestive Diseases and Nutrition, National Institute of Diabetes ... MD, Bldg 31,
Room 9A23, National Institutes of ... one can halt the progression of stage, or in ...

[BOOK] The Atlas of Heart Disease and Stroke -
J Mackay, GA Mensah - 2004 - books.google.com
... Thanks to our colleagues at the National Center for ... Smoking and Health, Centers for
Disease Control and ... for Community Medicine, All India Institute of Medical ...

[PDF] MRI of the hippocampus in Alzheimer?s disease: sensitivity, specificity, and analysis of the … -
MP Laakso, H Soininen, K Partanen, M Lehtovirta, M … - Neurobiol Aging, 1998 - uku.fi
... When novel pharmaceuticals to halt the progression of AD ... very earliest stages of
the disease (5,24 ... 38), 43 subjects fulfilling the National Institute of Mental ...
-

… of disease severity on outcome of antiviral therapy for chronic hepatitis C: lessons from the HALT- … -
GT Everson, JC Hoefs, LB Seeff, HL Bonkovsky, D … - Hepatology, 2006 - doi.wiley.com
... Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and
Kidney Diseases, National Institutes of ... The HALT-C Trial is being conducted ...

Peginterferon Alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior … -
ML Shiffman, AM Di Bisceglie, KL Lindsay, C … - Gastroenterology, 2004 - Elsevier
... Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney
Diseases, National Institutes of ... Treatment against Cirrhosis (HALT-C) Trial was ...

Source: Google Scholar

National Institutes of Health Award to Help Halt Disease Spread by Ticks

Roman Ganta, a professor of diagnostic medicine and pathobiology at Kansas State University, has been awarded a grant of $1,825,000 by the National Institutes of Health to figure out how to stop the tick-borne bacteria, Ehrlichia chaffeensis, from making animals and people sick.

This is the second grant of roughly the same size Ganta has received for this research.

Ehrlichia chaffeensis affects people and animals primarily in the southeastern and south central regions of the U.S. It is transmitted by the lone star tick. The resulting sickness, termed Ehrlichiosis, is hard to diagnose because its symptoms' similarities with other, more minor infections. Symptoms include headache, fever, malaise and muscle aches. For those with compromised immune systems, the bacterial infection could be fatal.

Though very few cases are reported -- around 1,500 since the Centers for Disease Control deemed it a disease of concern in the late 1980s -- Ganta estimates that as many as 50,000 people have actually contracted ehrlichia chaffeensis. Though relative to the nation's population that doesn't seem significant, the ensuing infection and symptoms can be serious, especially if untreated. As many as half of the patients diagnosed with ehrlichiosis require hospitalization.

This particular tick-borne pathogen is also unique because it circumvents the initial defenses of the immune system of the animal or human the tick bites, according to Ganta.

When bacteria enters the mammalian body the response is typically the same: the bacteria multiply and the immune system gears up, sending out its own organisms -- cells derived from white blood cells called macrophages -- to seek out and destroy the offender.

The average, healthy immune system can clear the body of most bacterial infections. But ehrlichia chaffeensis gets past that first line of defense, making the infection persist and the subsequent illness difficult to get rid of.

"It's like the enemy entering into a battlefield and knowing exactly where the landmines are and diffusing them all," Ganta said.

Over the last five years, Ganta's research team has been working under a prior federal grant, also from the National Institutes of Health, to uncover exactly how the bacteria works. They recreated the bacteria using cells from mice and from ticks. The current study revealed that the tick cells are what made the difference, and that the tick's ecology changes the bacteria by adding proteins, enabling bacteria to slip by the immune system.

"Understanding the molecular basis for persistence by these bacteria has been critical in developing effective methods to control this and other tick-borne pathogens," Ganta said. "Our research is focused on understanding the pathogen evasion mechanisms, and then using those to defeat it."

The trick now is to learn how to turn those proteins off, leaving the bacteria vulnerable, Ganta said. That's the research his new grant will fund.

Ganta said that tick-borne pathogens like ehrlichia chaffeensis have long been recognized as a persistent concern for the health of several companion animals and livestock. The number of cases in humans has also risen in recent years, increasing the threat to public health.

The hope is that once Ganta comes up with a way to fight off the bacteria, that will pave the way for solutions to other forms of ehrlichia, some of which are devastating for cattle and other food animals.

The $1,825,000 grant is for five years of study at $365,000 a year.
 
 
 
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