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Recent News and Articles on the Keywords: fat tissue + bone growth + bone  Related to the article below (Last Update: 5/13/2008)

Protein Summit 2007: Exploring the Impact of High-Quality Protein ...
Am J Clin Nutr (subscription), CA - May 9, 2008
Another factor influenced by protein is insulin-like growth factor (IGF-1), which plays a key role in bone metabolism. Higher levels of IGF-1 are ...
Protein Summit 2007: Exploring the Impact of High-Quality Protein ... Am J Clin Nutr (subscription)
all 8 news articles »

New York Times Blogs
Protecting Knees of Young Athletes
New York Times Blogs, NY -
... who have not finished growing because it involves drilling into a growth plate, an area of still-developing tissue at the end of the leg bone. ...

Natural News.com
Transform Yourself From the Inside-Out and Look Your Best Naturally
Natural News.com, AZ - May 11, 2008
Arginine is important in the formation of new bone and collagen. Dietary sources of this amino acid are cacao, carob, hemp seeds, celery, coconut, peanuts, ...
Cancer fighting virus
WHOI, IL - Apr 29, 2008
Non-soft tissue sarcomas (sometimes referred to as bone cancers) are those that develop in harder structures, like the bone or cartilage. ...
The art of science
Medill Reports, IL - May 8, 2008
Most of the young woman?s skin was burned off, so Mann drew the face using the woman?s bone structure as a model. Meanwhile, a mother called the police. ...
Consuming questions
Guelph Mercury, Canada - May 8, 2008
The third component is where the long term impact can really be seen: the effect on bone mineral density. Both low energy availability and lack of ...
Creating Beautiful Eyes and Eyebrows
Medscape (subscription) - Apr 30, 2008
Treating the temple area with fat on the bone is another approach. Temporary soft-tissue fillers. NASHAs are especially easy substances to use in cosmetic ...
Camel Cultures' New Use
Bernama, Malaysia - Apr 29, 2008
Camel fat tissue contains undifferentiated cells capable of turning into any of the body's specialised cell types. These cells, because they can branch into ...
Necrotizing Fasciitis of the Shoulder Following Routine Rotator ...
Journal of Bone and Joint Surgery (subscription) - May 1, 2008
Radiographs made at another institution revealed narrowing of the acromiohumeral distance and associated bone-spur formation. ...
Just another WordPress weblog
Judicium (subscription), WA - Apr 24, 2008
These include the increase of calcium retention, as well as that of bone mineralization; the creation of new muscle cells, which results in an increased ...
Source: Google News

Autologous Transplantation of Bone Marrow Cells Improves Damaged Heart Function -
S Tomita, RK Li, RD Weisel, DAG Mickle, EJ Kim, T … - Circulation, 1999 - Am Heart Assoc
... Differentiation of muscle, fat, cartilage, and bone ... Transplantation of fetal myocardial
tissue into the ... Cellular expression of bone-related proteins during in ...

Growth Patterns of Bovine Muscle, Fat and Bone -
RT Berg, RM Butterfield - Journal of Animal Science, 1968 - Am Soc Animal Sci
... relative pro*portions in different parts of the carcass and it is in- fluenced by
tissue distribution. Growth pat- terns of muscle, fat and bone will be ...

Is Leptin the Link Between Fat and Bone Mass? -
T THOMAS, B BURGUERA - Journal of Bone and Mineral Research, 2002 - Am Soc Bone Min Res
... responsible for protective effects of fat on bone ... dual effects depending on bone
tissue, skeletal maturity ... in life, leptin could stimulate bone growth and bone ...

Regional and total body bone mineral content, bone mineral density, and total body tissue composition … -
RA Faulkner, DA Bailey, DT Drinkwater, AA … - Calcified Tissue International, 1993 - Springer
... to muscle mass) to be positively associated with bone density [31 ... growth period the
percent of lean tissue increases and the percent of fat tissue decreases ...

The function of adipocytes in the bone marrow stroma: an update -
JM Gimble, CE Robinson, X Wu, KA Kelly - Bone, 1996 - Elsevier
... by the relationship between marrow fat and bone ... pa- tients, increased bone marrow
adipose tissue correlates with de- creased trabecular bone volume.6s In ...

Platelet-rich plasma: Growth factor enhancement for bone grafts. -
RE Marx, ER Carlson, RM Eichstaedt, SR Schimmele, … - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, …, 1998 - pt.wkhealth.com
... endosteal surface and randomly dispersed between fat cells in the ... growth factors
involved with general connective tissue repair and bone regeneration.5 ...

… in Bone Mineral Density, Body Composition, and Lipid Metabolism during Growth Hormone (GH) Treatment … -
AM Boot, MAMJ Engels, GJM Boerma, EP Krenning, … - Journal of Clinical Endocrinology & Metabolism, 1997 - Endocrine Soc
... childhood onset in adults and GHD in children are associated with reduced bone mineral
density (BMD) and lean tissue mass and increased fat mass (1 ...

PPAR ? insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors -
T Akune, S Ohba, S Kamekura, M Yamaguchi, U Chung, … - Journal of Clinical Investigation, 2004 - pubmedcentral.nih.gov
... Age-related variations of fat tissue fraction in normal human bone ... J. Bone Miner. ...
PPAR?: a nuclear regulator of metabolism, differentiation, and cell growth. ...

… of total body and regional bone mineral density in normal postmenopausal women--a key role for fat … -
IR Reid - Journal of Clinical Endocrinology & Metabolism, 1992 - Endocrine Soc
... in terms of either estrone production in fat tissue or the dependence of skeletal
load-bearing on fat mass ... important question to be addressed in bone biology ...

Leptin Inhibits Bone Formation through a Hypothalamic Relay A Central Control of Bone Mass -
P Ducy, M Amling, S Takeda, M Priemel, AF … - Cell, 2000 - Elsevier
... wt, ob/ob, or db/db mice and growth factors known ... and A-ZIP/F-1 transgenic mice that
have no fat tissue. Both bone volume (B) and bone formation rate (C) are ...

Source: Google Scholar

Fat tissue stimulates bone growth in children

Similar to what has been shown in young adults, fat tissue appears to stimulate bone growth in children who have yet to enter puberty, British researchers report. After puberty, this effect is weakened.

In a study reported in The Journal of Clinical Endocrinology and Metabolism, the fat mass in children was an independent predictor of bone mass and size as well as increases in these parameters over the next 2 years. There were some reasons to believe that fat tissue in children would have just the opposite effect to what was seen in adults, senior author Dr. J. H. Tobias, from the University of Bristol in the UK, and colleagues note. In young age groups, fat tissue has been shown to express enzymes that generate estrogen, a known inhibitor of bone growth. In addition, fat tissue may mediate reduced bone growth through increased levels of leptin, a hormone made by fat cells.

In studies involving more than 3,000 children with an average age of 9.9 years, Tobias and colleagues found that, even after accounting for height and lean body mass, total body fat mass showed a strong, direct association with bone mass and area.

As noted, the fat mass was also predictive of increases in bone mass and area over the next 2 years.

However, this positive correlation was confined to prepubertal boys and girls. In girls in the throes of puberty, either no association was seen or a negative correlation was noted. A significant interaction between puberty and fat mass was observed.

"Taken together, these observations provide strong evidence that adipose tissue acts to stimulate bone growth in prepubertal children," the authors conclude, whereas the onset of puberty leads to attenuation of the tendency for fat mass to stimulate bone growth.

 

Diabetic Kids Face Higher Risks Later

CHICAGO (AP) -- Children who get obesity-related diabetes face a much higher risk of kidney failure and death by middle age than people who develop diabetes as adults, a study suggests.

The study offers some of the first strong evidence of the consequences of the nation's growing epidemic of type 2 diabetes in children, said Dr. William Knowler, a co-author and researcher with the National Institute of Diabetes and Digestive and Kidney Diseases.

The research also lends support to warnings that diabetes and other obesity-related ills are on the verge of shortening average life span in the United States.

The study involved Pima Indians in Arizona, who have disproportionately high rates of diabetes and obesity. They may be "the tip of the iceberg, letting us know what's in the future for the rest of America if we don't do something about the childhood obesity epidemic," said Dr. David Ludwig, director of Children's Hospital Boston's obesity program. He was not involved in the research.

 

The study appears in Wednesday's Journal of the American Medical Association.

It involved a group of Indians whom National Institutes of Health researchers have been tracking since 1965. Of the 1,865 participants with Type 2 diabetes, 96 developed it in childhood. The average age of youth-onset diabetes was about 17 years, although the disease was diagnosed in children as young as 3 1/2.

During at least 15 years of follow-up, 15, or 16 percent, of those with childhood-onset type 2 diabetes developed end-stage kidney failure or died from diabetic kidney disease by age 55. That compared with 133, or 8 percent, of those who developed diabetes after age 20.

Most of the 20 million Americans with diabetes are adults with type 2. While a generation ago, type 2 diabetes was almost unheard of in children, the incidence has increased substantially in the past decade, largely because of obesity and lack of exercise.

Diabetes impairs the body's ability to regulate blood sugar levels. That can lead to damage to the kidneys and blood vessels throughout the body.

When type 2 diabetes develops earlier in life, it has many more years to cause damage and can lead to premature complications and death, the researchers said.

The American Diabetes' Association's Dr. Larry Deeb said that may not be the only explanation. During adolescence, kidneys are still maturing and may be particularly vulnerable to diabetes' effects, said Deeb, a pediatrics professor at the University of Florida.

While Pima Indians are among ethnic groups believed to have a genetic predisposition toward diabetes and obesity, the researchers said the results probably apply to others as well.

And even in people with a genetic predisposition, weight control and physical activity can help delay the onset of type 2 diabetes.

A recent study by pharmacy benefits manager Express Scripts Inc. found that prescriptions for type 2 diabetes drugs doubled among U.S. children ages 5 to 19 from 2002 to 2005.
 
 
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