Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California
blank

 

Recent News and Articles on the Keywords: liver cirrhosis + safe drug + drug  Related to the article below (Last Update: 5/13/2008)

Grapefruit Flavonoid Inhibits Hepatitis C Study Findings Suggest ...
EndoNurse, AZ - May 6, 2008
About three percent of the world?s population is infected with Hepatitis C virus, which can lead to cirrhosis and liver cancer. The current standard therapy ...
Gilead Initiates Letairis ? (ambrisentan) Phase IV Program
Business Wire (press release), CA - May 1, 2008
Letairis can cause elevation of liver aminotransferases (ALT and AST) to at least three times the upper limit of normal (ULN). ...GILD
Celera Reports Third Quarter Fiscal 2008 Results
Web Services Journal, NJ - Apr 24, 2008
Within the alliance with Abbott, the Chlamydia and Gonorrhea assays that run on the m2000 system were submitted during the quarter to the US Food and Drug ...CRA - HEL:ATRAV
NYC Residents Urged To Pass Hepatitis C Testing
eMaxHealth.com, NC - May 2, 2008
Some people can live with Hep C without ever suffering symptoms, but 15 percent of infected people develop cirrhosis ? a scarring of the liver that can lead ...
Source: Google News

… pharmacokinetic and pharmacodynamic considerations in patients with liver disease. An update. -
DJ Morgan, AJ McLean - Clin Pharmacokinet, 1995 - ncbi.nlm.nih.gov
... However, if cirrhosis is present, 'safe' drug use requires an awareness of the
possibility of ... In chronic liver disease with cirrhosis, dosage reduction ...

Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol …
T Livraghi, A Giorgio, G Marin, A Salmi, I de Sio, … - Radiology, 1995 - ncbi.nlm.nih.gov
... In patients with Child A cirrhosis, it was 36 ... CONCLUSION: PEI proved safe, effective,
and repeatable and had ... and absence of early mortality and liver damage of ...

Drug-induced hepatic injury. -
GC FARRELL - Journal of Gastroenterology & Hepatology, 1997 - pt.wkhealth.com
... of contemporary hepatology because: (i) many apparently safe drugs can rarely ... or
ultrastructure to fatal hepatic necrosis, cirrhosis and liver cancer; and ...

DRUG-INDUCED LIVER DISEASE -
HJ Zimmerman - Clinics in Liver Disease, 2000 - Elsevier
... disease (PSALD) is a drug-induced injury that ... hyaline, neutrophilic inflammation,
variable steatosis, and cirrhosis. ... the presence of chronic liver disease with ...

… -5-mononitrate in patients with cirrhosis. Effects on splanchnic and systemic hemodynamics and liver …
M Navasa, J Chesta, J Bosch, J Rodes - Gastroenterology, 1989 - ncbi.nlm.nih.gov
... portal hypertension in 23 patients with cirrhosis are reported ... in these quantitative
parameters of liver function ... could be a potentially useful and safe agent in ...

Grapefruit juice-drug interactions -
DG Bailey, J Malcolm, O Arnold, J David Spence - Br J Clin Pharmacol, 1998 - Blackwell Synergy
... juice consumption, at amounts considered safe for administration with ... Drug Metab
Dispos 1993; 21: 403? 409 ... in a case of liver cirrhosis and hepatocellular ...

In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease -
E Tanaka, DD Breimer - Journal of Clinical Pharmacy and Therapeutics, 1997 - Blackwell Synergy
... Erythromycin Safe Complex Many Easy ... F, Vedovelli A. (1981) The relationship between
aminopyrine breath test and severity of liver disease in cirrhosis. ...

… MANAGEMENT STRATEGY OF STEROID-FREE IMMUNOSUPPRESSION AFTER LIVER TRANSPLANTATION: EFFICACY AND … -
B Ringe, F Braun, E Sch?tz, L F?zesi, T Lorf, R … - Transplantation, 2001 - transplantjournal.com
... after liver transplantation is feasible and safe. ... because of their underlying liver
disease or ... in autoimmune hepatitis, primary biliary cirrhosis, or primary ...

Morbidity and mortality in cirrhotic patients undergoing anesthesia and surgery. -
A Ziser, DJ Plevak - Current Opinion in Anaesthesiology, 2001 - co-anesthesiology.com
... Drugs 1979; 17:198-212. ... Postoperative mortality in patients with liver cirrhosis
undergoing transurethral ... herniorrhaphy in cirrhotic patients: a safe approach. ...

Drug-induced hepatotoxicity -
WM LEE - Alimentary Pharmacology & Therapeutics, 1993 - Blackwell Synergy
... micronodular cirrhosis in as little as a few months time ... Liver biopsy at the time
of hospital discharge was ... profiles may change when apparently safe agents are ...

Source: Google Scholar

Anti-alcohol drug safe in cases of liver cirrhosis

Last Updated: 2007-12-07 10:01:31 -0400 (Reuters Health)

By Anthony J. Brown, MD

NEW YORK (Reuters Health) - The muscle-relaxing drug baclofen safely and effectively keeps alcoholics with alcohol-damaged livers away from alcohol, according to a study published in the current issue of The Lancet.

"This is the first study which tested a drug with the aim to reduce craving for alcohol and to increase alcohol abstinence in alcoholic patients affected by liver cirrhosis," lead author Dr. Giovanni Addolorato told Reuters Health.

"Although these patients need to maintain alcohol abstinence, usually they are excluded from trials with anticraving drugs because of concerns that these medications might worsen liver disease."

He explained that his group decided to test baclofen in this population because it is metabolized mostly by the kidneys, not the liver. Moreover, in previous studies of alcoholics without cirrhosis, the drug was effective and not associated with liver side effects.

The study involved 84 patients who were randomized to receive baclofen pills or placebo for 12 weeks. Patients treated with baclofen were much more likely to achieve and maintain abstinence (71 percent) than were controls (29 percent), Addolorato, from the Catholic University of Rome, and colleagues report.

Patients taking baclofen also abstained from alcohol for more than twice as long as patients given placebo (62.8 days versus 30.8 days).

Baclofen therapy was well tolerated and no liver-related side effects.

Alcohol remains the chief cause of liver cirrhosis in developed countries, the investigators note in their report. Persistent alcohol intake in people with alcoholic cirrhosis often leads to death. Individuals with alcoholic liver disease need to achieve total alcohol abstinence, since medical and surgical treatments for alcoholic liver diseases have limited success when drinking continues, they further note.

"Our results suggest that baclofen, because of its anticraving action and safety, could have an important role for treatment of alcohol-dependent patients with advanced liver disease," the investigators conclude.

SOURCE: Lancet, December 8, 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
Google
Web www.iconocast.com

Search inside Iconocast for the keyword you have in mind.

Iconocast has collected more than 50,000 articles and press releases on health and science.

These are current and most up to date press releases on the subject you are searching.

We collect current health and science press releases daily from more than 5000 research and health institutes. Here is an example : The elderberry way to perfect skin

We believe if you do search inside Iconocast, you will get better results than searching the web alone.

 
 
Continue News With: News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services.

 

Iconocast Home Page

Contact Iconocast

© 2003-07. ICONOCAST is a trademark of iconocast.com.