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Recent News and Articles on the Keywords: breast development + household chemical + breast  Related to the article below (Last Update: 5/13/2008)

Uganda: Uganda Network on Toxic Free Malaria Control (UNETMAC ...
AllAfrica.com, Washington - May 5, 2008
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KLEW
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State chemists Hooper and Myrto Petreas and their teams had found that women in Northern California had some of the world's highest PBDE levels in breast ...
BITS AND PIECES
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A few issues back, we reported that trees are able to vary the chemical composition of their leaves to defend themselves against insect attacks. ...
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Chemical contaminants in breast milk and their impacts on children?s health: an overview -
PJ Landrigan, B Sonawane, D Mattison, M McCally, A … - Environ Health Perspect, 2002 - JSTOR
... water, and occupational and household environments. ... conference, "Chemical Contaminants
in Breast Milk: Impacts ... Child Health and Human Development, the National ...

Pesticides and Breast Cancer Risk: A Review of DDT, DDE, and Dieldrin -
SM Snedeker - Environmental Health Perspectives, 2001 - pubmedcentral.nih.gov
... Contribution of household dust to the human exposure to pesticides ... concentrations
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Age at Menarche and Tanner Stage in Girls Exposed In Utero and Postnatally to Polybrominated … -
HM Blanck, M Marcus, PE Tolbert, C Rubin, AK … - Epidemiology, 2000 - epidem.com
... of Tanner stage schematic drawings of both breast and pubic hair development. ...
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The Effect of Environment on Breast Cancer Risk -
YM Coyle - Breast Cancer Research and Treatment, 2004 - Springer
... toxins were identified and measured in household dust and ... that are not causally
associated with breast cancer in ... to enhance or inhibit tumor growth in rodents ...

… of insulin-like growth factor (IGF)-II in human prostate, breast, bladder, and paraganglioma tumors -
SL Li, H Goko, ZD Xu, G Kimura, Y Sun, MH Kawachi, … - Cell and Tissue Research, 1998 - Springer
... buffer for 20 min by using a household Black and ... ME, Rosen N (1990) Insulin-like
growth factor receptor expression and function in human breast cancer ...

ENVIRONMENTAL RISK FACTORS AND FEMALE BREAST CANCER -
F Laden, DJ Hunter - Annual Reviews in Public Health, 1998 - Annual Reviews
... suggested that vitamin D inhibits growth of breast ... including pesticide levels in
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… (PCNA) immunohistochemistry with histopathological parameters and prognosis in primary breast … -
T Haerslev, GK Jacobsen, K Zedeler - Breast Cancer Research and Treatment, 1996 - Springer
... twice for 5 minutes in a household microwave oven ... In breast carcino- mas PCNA
immunoreactivity correlates with flow ... lower values than Ki-67 growth fraction or ...

Risk Factors for Breast Cancer in Jordanian Women -
W Petro-Nustas, ME Norton, I Al-Masarweh - Journal of Nursing Scholarship, 2002 - Blackwell Synergy
... Four experts in research instrument development from the ... The risk of developing breast
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Organochlorine exposure and breast cancer survival -
AP H?yer, T J?rgensen, JW Brock, P Grandjean - Journal of Clinical Epidemiology, 2000 - Elsevier
... menopausal status, alcohol consumption, smoking, and household income ... be a consequence
of tumor growth promotion ... Organochlorine exposure and risk of breast cancer ...

Anthropometric variables in relation to risk of breast cancer in middle-aged women -
CI Li, JL Stanford, JR Daling - International Journal of Epidemiology, 2000 - IEA
... 25 Harlow BL, Davis S. Two one-step methods for household screening and ... McCormack,
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Source: Google Scholar

Breast Development May Be Affected By Household Chemical
A chemical found in household fittings has been found to affect the development of the mammary gland in rats and further studies will be required to determine if the presence of this chemical could lead to breast cancer. New research published in the online open access journal BMC Genomics is the first to show that this chemical can affect the breasts' genomic profile.

Jose Russo and coworkers from the Fox Chase Cancer Center in Philadelphia, along with colleagues from the University of Alabama in Birmingham, US, fed lactating rats with butyl benzyl phthalate (BBP), which their offspring then absorbed via breast milk. The offspring ingested levels of chemical estimated to be nearly equivalent to the Environmental Protection Agency's safe dose limit of BBP for humans.

The researchers found that BBP had a transitory effect on certain characteristics of the female offspring of the rats, such as the ratio of uterine weight to body weight and the genetic profile of the mammary gland. Dr Russo stated: "We are the first to report that neonatal/prepubertal exposure to BBP induced modifications in the gene expression of the mammary tissue."
Although these effects wore off once exposure to BBP was removed, the subtle changes in the mammary gland may have an effect later in life.

BBP is widely used as a plasticizer, an additive used to soften polymers, and is found in household fittings such as pipes, vinyl floor tiles and carpet backing. This type of chemical is known to be an endocrine disruptor, which mimics the effect of hormones. Endocrine disruptors are known to damage wildlife and they have also been implicated in reduced sperm counts and neurological problems in humans.

Article:
The plasticizer butyl benzyl phthalate induces genomic changes in rat mammary gland after neonatal/prepubertal exposure
Raquel Moral, Richard Wang, Irma H Russo, Daniel A Mailo, Gabriela Balogh, Coral A Lamartiniere, Jose Russo
BMC Genomics(in press)

BMC Genomics is an open access journal publishing original peer-reviewed research articles in all aspects of gene mapping, sequencing and analysis, functional genomics, and proteomics. BMC Genomics (ISSN 1471-2164) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, Scopus, EMBASE, Zoological Record, Thomson Scientific (ISI) and Google Scholar.

BioMed Central (http://www.biomedcentral.com)/) is an independent online publishing house committed to providing open access to peer-reviewed biological and medical research. This commitment is based on the view that immediate free access to research and the ability to freely archive and reuse published information is essential to the rapid and efficient communication of science.

BioMed Central currently publishes over 180 journals across biology and medicine. In addition to open-access original research, BioMed Central also publishes reviews, commentaries and other non-original-research content. Depending on the policies of the individual journal, this content may be open access or provided only to subscribers.

Source: Charlotte Webber
BioMed Central
 
 
 
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