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Recent News and Articles on the Keywords: powerful tool + genetics + inflammation  Related to the article below (Last Update: 5/13/2008)

MRI Emerges as Breast Cancer Tool
CancerWise - May 8, 2008
?However, our message is that breast MRI is a powerful tool if used judiciously.? Yang says breast MRI should not be regarded as a first-line tool for all ...
Events & Announcements
Nova Scotia Business Journal, Canada - May 9, 2008
Women's leadership workshop on May 30: This is a workshop for women packed with a powerful combination of practical tips and leadership inspiration. ...
Genostar Expands Deal with Biopharma Merial To Help Hunt ...
bio1nf0rm (subscription), NY - May 9, 2008
One gene-prediction tool within the software has been developed specifically for prokaryotic genomes. The method, called Prokov and found in the software?s ...
DNA analysis holds some answers, but not every claim is credible
NewsOK.com (subscription), OK - May 5, 2008
DNA analysis is a powerful tool, Brandt Cassidy said. But to say it can do all these things is stretching the technology and the credibility of the science ...
Charting The Epigenome: Zooming In On Genome-wide DNA At Single ...
Science Daily (press release) - Apr 17, 2008
Discoveries in recent years made it increasingly clear that there is far more to genetics than the sequence of building blocks that make up our genes. ...

WTN News
CIO touts integration of genetic data with electronic health records
WTN News, WI - Apr 30, 2008
?I don't think there is any doubt that it is a phenomenally powerful tool that can help an organization,? he said. ?I don't think very many people say, ?Oh, ...
The Don Monti Foundation Awards $500000 Grant to Cold Spring ...
Media Newswire (press release), NY - Apr 28, 2008
Without the support from the Monti Foundation, Lowe says, "there was no way" the team could have acquired this powerful tool. In 1972, Joseph and Tita Monti ...LOW
UMS to stay competitive via Internet 2
Bangor Daily News, ME - Apr 24, 2008
"This fiber-optic based research and education network is a powerful tool that solidifies Maine?s appeal and potential as a high-tech center of research, ...
HudsonAlpha associate firms
The Huntsville Times - al.com, AL - Apr 20, 2008
Expression Genetics (EGEN) is a privately-held, specialty biopharmaceutical company developing polymeric delivery systems for nucleic acids. ...
Scientists Find Human Ageing Gene In Flies
RedOrbit, TX -
... as a model for the genetics behind mechanisms that underlie normal functioning of the human body and it is great news that this powerful research tool ...
Source: Google News

Lessons from genetic models of inflammatory bowel disease.
DK Podolsky - Acta Gastroenterol Belg, 1997 - ncbi.nlm.nih.gov
... In still other models, inflammation may not occur ... Further, they offer powerful tools
for exploring the interaction between genetic and environmental ...

Recombinant Congenic Strains Derived from A/J and C57BL/6J: A Tool for Genetic Dissection of Complex … -
A Fortin, E Diez, D Rochefort, L Laroche, D Malo, … - Genomics, 2001 - Elsevier
... The AcB/BcA set should prove a useful tool with which ... 7 Murine AIDS 21 LPS-induced
inflammation 31 ... markers were purchased from Research Genetics (Huntsville, AL ...

A systems approach to dissecting immunity and inflammation -
A Aderem, KD Smith - Seminars in Immunology, 2004 - Elsevier
... in different species provides powerful tools for identifying ... technologies for dissecting
immunity and inflammation. ... by global analyses of genetic variation and ...

Experimental Models to Study Molecular Mechanisms Underlying Intestinal Inflammation -
CO ELSON, Y CONG, S BRANDWEIN, CT WEAVER, RP … - Annals of the New York Academy of Sciences, 1998 - Blackwell Synergy
... Inbred strains of mice represent a powerful genetic tool. ... susceptible to colitis
independent of the mutation or chemical used to induce colon inflammation. ...

Assessment of inflammation and nutrition in patients with end-stage renal disease -
BR Don, GA Kaysen - J Nephrol, 2000 - sin-italy.org
... and BIA) may prove to be powerful tools to identify ... recently been identified as a
powerful predictors of ... inflammation, oxidative stress and genetic components. ...
-

Interleukin-6 Gene-174G> C and-572G> C Promoter Polymorphisms Are Strong Predictors of Plasma … -
DJ Brull, HE Montgomery, J Sanders, S Dhamrait, L … - Arteriosclerosis, Thrombosis, and Vascular Biology, 2001 - Am Heart Assoc
... transcriptional regulation in vitro, making them potential powerful tools worthy
of ... evidence for the use of these genetic markers as tools in just such ...

Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial … -
SR Hustinx, D Cao, A Maitra, N Sato, ST Martin, D … - Cancer Biol Ther, 2004 - ncbi.nlm.nih.gov
... 1), differentiation (DMBT1 and Neugrin), immune response (CD74), inflammation (CXCL2),
cell ... TAGmapper should prove to be a powerful tool for the discovery of ...

… trait loci modulate neutrophil infiltration in the liver during LPS-induced inflammation -
LE MATESIC, EL NIEMITZ, M DE? - The FASEB Journal, 2000 - FASEB
... important component in the regulation of inflammation. ... mouse system provides a powerful
tool for unraveling ... limits the sources of genetic variation, providing ...

Genetic Differences in Endothelial Cells May Determine Atherosclerosis Susceptibility -
JL Breslow - Circulation, 2000 - Am Heart Assoc
... The article demonstrates that the induction of an inflammation-related phenotype ...
step in the process of using the powerful tools of mouse genetics to help ...

Genetic and pharmacological analysis of prostanoid receptor function -
S Narumiya, GA FitzGerald - Journal of Clinical Investigation, 2001 - pubmedcentral.nih.gov
... Indeed, prostanoids formed during inflammation are not ... agonists and antagonists provide
powerful tools for studying the ... on a pure genetic background become ...

Source: Google Scholar

Powerful Tool to Study the Genetics of Inflammation Developed

Scientists have known which genes are linked to inflammation, but now researchers at Wake Forest University Baptist Medical Center have organized this information to develop a powerful tool to aid investigators in studying the genetics of inflammatory diseases.

Using complex web-based software called Ingenuity Pathway Analysis®, the researchers were able to systematically map out pathways, or chains of genes, and subpathways that contribute to various aspects of inflammation.

“We basically organized the inflammation-associated genes in a systematic way,” said Matthew Loza, Ph.D., of the Center for Human Genomics at Wake Forest University School of Medicine, and lead author of the study. “Before, a random list of genes involved in inflammation was all you had. We started with that same list, but then built these networks to bring all these different genes together.”

The study, which was recently published by the Public Library of Science in its online journal PLoS One, has also led to the development of two customized panels for analyzing genetic variations in the inflammation pathways -- one for European and one for African descent populations. In a laboratory, these panels are analyzed using special laboratory equipment and computer systems. Researchers can obtain the custom inflammation panel through Affymetrix Corporation.

“This is so significant because inflammation is a very hot topic, and many research groups want to study it,” said Bao-Li Chang, Ph.D., assistant professor of pediatrics at Wake Forest and senior author for the study. “We have provided researchers with the tool to effectively and efficiently accomplish their goals.”

Inflammation is the immune system’s response to pathogens and tissue damage. Chronic inflammation is linked to numerous diseases, including rheumatoid arthritis, cardiovascular disease, and many cancers.

This study is part of a larger study through the Women’s Health Initiative that explores the role of inflammation in colon, breast and lung cancer. It’s sponsored by the National Heart, Lung and Blood Institute of the National Institutes of Health.

Co-researchers were Charles McCall, M.D., and Jianfeng Xu, Dr. P.H., of Wake Forest, Liwu Li, Ph.D., of the Virginia Polytechnic Institute and State University, and William Isaacs, Ph.D., of Johns Hopkins University Medical Institutions.

Wake Forest University Baptist Medical Center is an academic health system comprised of North Carolina Baptist Hospital and Wake Forest University Health Sciences, which operates the university’s School of Medicine. The system comprises 1,238 acute care, psychiatric, rehabilitation and long-term care beds and is consistently ranked as one of “America’s Best Hospitals” by U.S. News & World Report.
 
 
 
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