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Recent News and Articles on the Keywords: neuropathic pain + protein found + pain  Related to the article below (Last Update: 5/13/2008)

Cone Snails And Plants Used To Develop Oral Drug For Pain
Science Daily (press release) - Apr 16, 2008
Studies on the molecule they have developed have shown that it is effective in relieving neuropathic pain in animals. "Neuropathic pain is one of the most ...
Biovitrum Presents Detailed Results From Clinical Neuropathic Pain ...
ABN Newswire (press release), Australia - Apr 29, 2008
One study involved the treatment of glaucoma (5-HT2A receptor antagonist) and the other neuropathic pain in diabetes patients (pH selective A2A receptor ...STO:BVT
How snails can help treat chronic pain
Thaindian.com, Thailand - Apr 16, 2008
Studies have shown that these molecules are effective in relieving neuropathic pain in animals, a very severe form of chronic pain and very difficult to ...
Biovitrum Presents Detailed Results
Ad-Hoc-News (Pressemitteilung), Germany - Apr 29, 2008
One study involved the treatment of glaucoma (5-HT2Areceptor antagonist) and the other neuropathic pain in diabetespatients (pH selective A2A receptor ...STO:BVT
Source: Google News

… microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain -
SX Jin, ZY Zhuang, CJ Woolf, RR Ji - J Neurosci, 2003 - Soc Neuroscience
... Similar articles found in: J. Neurosci ... BRIEF COMMUNICATION p38 Mitogen-Activated
Protein Kinase Is ... Neurons and Contributes to the Generation of Neuropathic Pain. ...

Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKC {gamma} -
AB Malmberg, C Chen, S Tonegawa, AI Basbaum - Science, 1997 - sciencemag.org
... A selective deficit is found in the development of ... I regulatory subunit (RI ) of
protein kinase A ... showed no change in the neuropathic pain behavior produced by ...

[PDF] Neuropathic pain: aetiology, symptoms, mechanisms, and management -
CJ Woolf, RJ Mannion - Lancet, 1999 - anat.ucl.ac.uk
... that are insensitive to tetrodotoxin are found only on ... The effect of gabapentin on
neuropathic pain. ... Protein kinase C reduces Mg2+ block of NMDA- receptor ...
-

Pathobiology of neuropathic pain -
M Zimmermann - European Journal of Pharmacology, 2001 - Elsevier
... many functions including growth-related proteins. ... 2+ channels have been found to
contribute ... or intra-/extracellular calcium concentration in neuropathic pain. ...

Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2 -
C Abbadie, JA Lindia, AM Cumiskey, LB Peterson, JS … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences
... inflamed, and neuropathic groups or samples from neuropathic groups at ... 1. CCR2 mRNA
in various tissues during chronic pain states. CCR2 Protein Distribution. ...

… of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain. -
S Hao, M Mata, W Goins, JC Glorioso, DJ Fink - Pain, 2003 - ncbi.nlm.nih.gov
... of herpes simplex virus (HSV) vector-mediated expression of proenkephalin in the
dorsal root ganglion in a rodent model of neuropathic pain. We found that: (i ...

… of p 38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain … -
M Tsuda, A Mizokoshi, Y Shigemoto-Mogami, S … - Glia, 2004 - doi.wiley.com
... ABSTRACT Neuropathic pain is an expression of pathological ... and is characterized by
pain hypersen- sitivity to ... of p38 mito- gen-activated protein kinase (p38MAPK ...

… tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain -
S Sweitzer, D Martin, JA DeLeo - Neuroscience, 2001 - Elsevier
... in the modulation of a persistent neuropathic pain state ... therapy was found to return
IL-6 protein levels in ... IL-6 is potentially important in pain etiologies as ...

GABAPENTIN USE IN NEUROPATHIC PAIN SYNDROMES -
B Nicholson - JPNS, 2000 - Blackwell Synergy
... FOR THE RELIEF OF HIV-ASSOCIATED NEUROPATHIC PAIN Paice JA ... in studies of non-
pharmacologic therapies for pain. ... mutation of peripheral myelin protein 22 (PMP22 ...

Neuropathic pain and spinal microglia: a big problem from molecules in ?small?glia -
M Tsuda, K Inoue, MW Salter - Trends in Neurosciences, 2005 - Elsevier
... 4 receptor [38] and p38 mitogen-activated protein kinase (MAPK ... that appears to be
required for neuropathic pain [38 ... It was found that the cells expressing P2X 4 ...

Source: Google Scholar

Protein Found That May Provide Relief from Neuropathic Pain

A New Protein Found in the Blood May Provide Relief from Neuropathic Pain
Neuropathic pain is caused by injury to the peripheral nerves in diseases such as HIV/AIDS, shingles, and cancer or in repetitive motion disorders and trauma, and does not respond well to conventional pain-relieving drugs.

Research in rodents by scientists from the University of California, San Diego (UCSD) School of Medicine has provided evidence that a protein called LRP1 may help to ease neuropathic pain by blocking the response of glial cells that support and protect sensory neurons in the peripheral nervous system. Their findings, which could represent a novel target for neuropathic pain therapy, are published in the December 3 issue of the Journal of Clinical Investigation.

“Neuropathic pain differs from ordinary pain in that it is usually perceived as ongoing burning or as ‘pins and needles’ electric-shock type of sensation,” said Wendy Campana, Ph.D., associate professor in UCSD’s Department of Anesthesiology, who led the study. “It is caused by nerve damage that can be associated with chronic inflammation or direct nerve injury.”

The UCSD studies show that a form of LRP1 that is present in body fluids such as blood counteracts the activity of inflammatory cytokines, proteins which are involved in developing and sustaining chronic pain states. Cytokines act as messengers to either stimulate or inhibit the immune response, are produced by many cell types including white blood cells present during infection and inflammation

“We think that the anti-inflammatory activity of LRP1 can be harnessed to decrease chronic pain,” said Campana. “By decreasing the presence of cytokines in the area of nerve damage, LRP1 calms the pain signals that are sent to the spinal cord.”
In-vitro analysis confirmed that LRP1 works to modify the response of glial cells that results in neuropathic pain, according to Campana, who added that interactions of neurons and glial cells are very important in determining pain.

Campana worked with post-doctoral scholar Alban Gaultier, Ph.D., and Steven L. Gonias, M.D., chair of UCSD’s Department of Pathology, who are exploring other aspects of LRP1 function. The UCSD scientists observed that injured peripheral nerves in both mice and rats release LRP1 into the surrounding tissue.

Administration of LRP1 into the rodents’ sciatic nerves prior to injury provided a protective effect, decreasing the level and activity of injury-induced proinflammatory cytokines, such as TNF-alpha, in the local environment and inhibiting spontaneous pain.

In addition to decreasing inflammatory cytokines locally, treatment with LRP1 also decreased inflammatory cytokines in a region called the spinal dorsal horn, where central pain processing occurs.

“TNF-alpha has some positive properties in infection, so you may not want to block its activity entirely,” said Campana. “It appears that LRP1 limits, but doesn’t completely block, the increase in proinflammatory cytokines produced by glial cells after nerve injury. We think this research opens up a number of new research directions for understanding and treating chronic neuropathic pain.”

Additional contributors to this study include Sanja Arandjelovic and Nikola Dragojiovic, UCSD Department of Pathology; Robert R. Myers, UCSD Departments of Pathology and Anesthesiology; and Xiaoqing Li, Julie Janes, George P. Zhou and Jenny Dolkas, UCSD Department of Anesthesiology. The research was supported in part by grants from the National Institutes of Health.
 
 
 
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