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Recent News and Articles on the Keywords: aristolochia clematis + wheat fields + plant  Related to the article below (Last Update: 5/5/2008)

The View from Sunnybank: Don't panic
Traverse City Record Eagle, MI - Apr 13, 2008
It mingles with CLEMatis terniflora, a vine that blooms in September. (Bulletin: Bugs ignore both.) Got a computer? Go to "Google." Type in "Aristolochia ...
Source: Google News

Observations on the poisonous plants of Michigan
EF Woodcock - American Journal of Botany, 1925 - JSTOR
... 35. Aristolochia sipho L'Her. ... Wheat screenings which contain a large amount of cockle
are poison- ous to stock. ... 52. Clematis virginiana L. Virgin's Bower. ...

Balkan endemic nephropathy: a need for novel aetiological approaches -
V Stefanovic - QJM, 1998 - Oxford Univ Press
... power field. ... aristolochic acid in flour obtained from wheat con- ... taminated with seeds
of Aristolochia clematis in of BEN were found among the population of the ...

Ecology of Chondrilla juncea L. in south-eastern Australia
DN McVean - Journal of Ecology, 1966 - JSTOR
... tenuifolia, Amaranthus silvester and Aristolochia clematis in central ... transpire less
than potted wheat plants and are ... of considerable importance in the field. ...

Fate of plant-derived secondary metabolites in three moth species (Syntomis mogadorensis, Syntomeida … -
M Wink, D Schneider - Journal of Comparative Physiology B: Biochemical, Systemic, …, 1990 - Springer
... above for Syntomis, mainly with young wheat leaves (5 ... limited survival chances under
harsh field conditions ... 100 Alyssum saxatile GL 0 Aristolochia clematis AA 0 ...

Alien vascular plants in Massachusetts
BA Sorrie - Rhodora, 2005 - bioone.org
... species had become established away from gardens and crop fields. ... Woody Aristolochia
species in western Massachusetts. ... Recent plant collections-Massachusetts. ...

[BOOK] Gleason's Plants of Michigan: A Field Guide
RK Rabeler - 2007 - books.google.com
... during seven different summers at the Station, offering one or more of the following
courses; systematic botany, field and forest botany, plant ecology, or ...

List of Vascular Plants of the Northern Triassic Area of Virginia
HA Allard, EC Leonard - Castanea, 1962 - JSTOR
... ARISTOLOCHIA SERPENTARIA L. In dry soil off route 681, one mile SE of ... CLEMATIS
OCHROLEUCA Ait. In woods, thickets and border of fields and thickets, on various ...

Weed allelopathy, its ecological impacts and future prospects: a review -
JR Qasem, CL Foy - J. Crop Prod, 2001 - haworthpress.com
... facing researchers in the field of allelopathy ... Argemone mexicana Living plants Bajra,
mustard, radish ... and Nathawat, 1987 wheat Aristolochia clematitis Extract ...

[PDF] VEGETATION
AF CHECKLIST - tpwd.state.tx.us
... brochures available at the Management Area office include field checklists for ... Woody
Plants Trees ? Boxelder Acer negundo ? Maple, Red Acer rubrum Buckeye ...

[BOOK] Flowers of the Field
CA Johns - 1853 - Society for Promoting Christian Knowledge

Source: Google Scholar

Birthwort Plant’s Dark Side: Contaminated Grain Linked To Kidney Disease and Cancer In Balkan Countries

 

Seeds from birthwort (Aristolochia clematis), a plant which grows in wheat fields in the Balkan region and which has been used throughout Europe and Asia as an herbal remedy for 2000 years, is contaminating the wheat grain, leading to a devastating kidney disease affecting rural residents in that region, a study led by Dr. Arthur Grollman of Stony Brook University and published in Proceedings of the National Academy of Sciences (July 17) suggests. Endemic (Balkan) nephropathy (EN), a kidney disease found in farming villages in Bosnia, Bulgaria, Croatia, Romania and Serbia, progresses rapidly to chronic renal failure and is strongly associated with upper urinary tract cancer.

To investigate the environmental source of this disease, Dr. Arthur Grollman, Distinguished Professor of Pharmacological Sciences at Stony Brook University Medical Center, and his colleagues in the US, in collaboration with researchers in Croatia, analyzed DNA samples obtained from renal tissues of patients affected by the disease. The researchers detected DNA damage caused by a chemical called aristolochic acid in patients with EN but not in patients with other forms of chronic kidney disease. They also discovered the mutational fingerprint of aristolochic acid in a gene associated with EN-related urinary tract cancer.

Because this toxin is produced by the Aristolochia clematitis, or birthwort, plant, which is native to the region, Dr. Grollman and his colleagues postulate that contamination of grain with seeds of this plant, leading to chronic dietary poisoning, is the cause of endemic nephropathy.

This finding has significant implications for strategies to eliminate EN from the Balkan peninsula and for dealing with kidney disease in other areas where the plant is used in traditional herbal remedies. Additionally, by bringing to bear genomics, pathology, environmental sciences, biochemistry, and clinical medicine, Dr. Grollman has created an important approach for research in other environmental diseases.

Journal Article:
Aristolochic acid and the etiology of endemic (Balkan) nephropathy, by Arthur P. Grollman, Shinya Shibutani, Masaaki Moriya, Fredrick Miller, Lin Wu, Ute Moll, Naomi Suzuki, Andrea Fernandes, Thomas Rosenquist, Zvonimir Medverec, Krunoslav Jakovina, Branko Brdar, Neda Slade, Robert J. Turesky, Angela K. Goodenough, Robert Rieger, Mato Vukelic, and Bojan Jelakovic.
 
 
 
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