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Recent News and Articles on the Keywords: uab researchers + university of + uab  Related to the article below (Last Update: 5/5/2008)

UAB health disparities grant to help older blacks in rural areas
The Birmingham News - al.com, AL -
UAB will lead a collaboration with Morehouse School of Medicine, Tuskegee University and the University of Alabama. Its center will focus on blacks living ...
UAB, Glenwood achieve autism research
The Kaleidoscope, AL - Apr 29, 2008
On Wednesday, April 23, the UAB School of Public Health presented the Glenwood Endowed Lecture Series, a joint effort between UAB and Glenwood to heighten ...
Head and shoulders above
Scenta.co.uk, UK - May 1, 2008
Researchers at the University of Birmingham (UAB), USA, have pioneered a new surgical technique for head and neck cancer. Although robotic surgery has been ...
UAB research shows Ph levels of various drinks
The Birmingham News - al.com, AL - Apr 21, 2008
Researchers at the University of Alabama at Birmingham School of Dentistry measured the Ph of a variety of liquids and found energy drinks to be among those ...
First Thermal Nanomotor In The World Has Been Created
Science Daily (press release) - Apr 15, 2008
ScienceDaily (Apr. 15, 2008) ? Researchers from the UAB Research Park have created the first nanomotor that is propelled by changes in temperature. ...

TechJournal South
University of Alabama drug fights cystic fibrosis
TechJournal South, NC - Apr 21, 2008
... effective in treating muscular dystrophy also works for cystic fibrosis, according to researchers at the University of Alabama at Birmingham (UAB). ...
HEART FAILURE, HOSPITALIZATION, UAB, MORTALITY,
Newswise (press release) - Apr 10, 2008
Dr. Ahmed?s co-researchers were Richard M. Allman, MD, and Louis Dell?Italia, MD, from UAB; Gregg Fonarow, MD, from the University of California in Los ...

CNN
Deadly critters that might save your life
CNN - Apr 8, 2008
But it just might cure you: Medical researchers at the University of Alabama at Birmingham (UAB) have discovered a new use for scorpion venom -- cancer ...
Stroke therapy developed at UAB can restore half of arm function ...
al.com, AL - Apr 23, 2008
The most recent findings were largely produced by Lynne Gauthier, a graduate student in Taub's laboratory at UAB. Gauthier used a cutting-edge technique, ...
Based on research partially performed at UAB, new guidelines help ...
The Birmingham News - al.com, AL - Apr 17, 2008
The new guidelines, based on research partially conducted at UAB, greatly expand the number of factors considered in making difficult decisions about ...
Source: Google News

Plagiarism suit wins; experts hope it won't set a trend -
G Taubes - Science, 1995 - sciencemag.org
... against University of Utah burn researcher John Ninnemann ... Berge case encour- ages
disgruntled researchers to shunthe ... could promote chaos." The UAB legal office ...

[BOOK] Handbook of Health Promotion and Disease Prevention -
JM Raczynski, RJ DiClemente - 1999 - books.google.com
... Birmingham, Birmingham, Alabama 35294 Sten H. Vermund, Department of Epidemiology,
School of Public Health, UAB Center for AIDS Research, University of Alabama ...

Subjective symptomatology of asthma in an outpatient population -
CM Brooks - Psychosomatic Medicine, 1989 - Am Psychosomatic Soc
... ingly, the present research studied the ASC in the context of an outpatient pro-
gram developed at the University of Ala- bama at Birmingham (UAB) to promote ...

[BOOK] Appraisal Processes in Emotion: Theory, Methods, Research
KR Scherer, A Schorr, T Johnstone - 2001 - books.google.com
... Part VII: Perspectives for Theory and Research 21 The ... D. Kirby Department of Psychology
University of Alabama at Birmingham UAB Station Birmingham, AL ...

Periodontal infection and preterm birth Results of a prospective study -
MK JEFFCOAT, NC GEURS, MS REDDY, SP CLIVER, RL … - The Journal of the American Dental Association, 2001 - Am Dental Assoc
... Such a prospective study is under way at the University of Alabama at Birmingham,
or UAB, and is being conducted jointly by clinical researchers from the ...

Promoting Self-Management in Adults with Asthma: An Overview of the UAB Program -
WC Bailey, JM Richards Jr, BA Manzella, RA Windsor … - Health Education & Behavior, 1987 - heb.sagepub.com
... This work is supported by research funding from the ... University of Alabama at Birmingham;
Birmingham, AL 35294. ... The UAB program is based on the Health Belief ...

Baseline conditions and subtractive logic in neuroimaging -
SD Newman, DB Twieg, PA Carpenter - Human Brain Mapping, 2001 - doi.wiley.com
... Each gave informed written consent approved by the University of Alabama at ... magnet
and gradients, located at the Center for Nuclear Imaging Research at UAB. ...

How regions converge
F Caselli, W Coleman - Journal of Political Economy, forthcoming - ideas.repec.org
... 447.00, Unitat de Fonaments de l'An?lisi Econ?mica (UAB) and Institut d ... Paper CRENoS
200103, Centre for North South Economic Research, University of Cagliari ...
-

Scale for Assessing Functional Impairment in Adults with Asthma -
R Player, JM Richards, CL Kohler, LL Woodby, CM … - Journal of Asthma, 1994 - informaworld.com
... This research describes one such measure, the University ot Alabama at ... The psychometric
properties of the UAB Scale were assessed in two samples. ...

African-American Attitudes Regarding Cancer Clinical Trials and Research Studies: Results from Focus … -
BL Green, PhD, EE Partridge, MD, MN Fouad, MD, MPH … - Ethnicity & Disease, 2000 - apt.allenpress.com
... in clinical cancer research and to stimulate local/regional adaptations of these
strategies. The University of Alabama at Birmingham (UAB), The University of ...

Source: Google Scholar

Researchers Say New Stem Cell Technique Cures Sickle Cell in Mice

 

Researchers at UAB (University of Alabama at Birmingham), along with a team from the Whitehead Institute, report successfully treating sickle cell anemia in mouse models using induced pluripotent stem (iPS) cells, a new stem cell technique that uses skin cells and does not require embryos. The findings, published in Science Express Online on Dec. 6, are the first to actually use the iPS technique to treat disease in an animal model.

The iPS technique received widespread attention in November when two laboratories reported using the process to turn human skin cells into stem cells, cells which can then be induced to form any other type of cell. Scientists believe stem cells have great potential in treating a variety of human diseases.

“The UAB/Whitehead teams took skin cells from mouse models genetically engineered to have sickle cell disease and reprogrammed them into iPS cells by adding four genes to each cell,” said Tim M. Townes, Ph.D., professor and chair of the Department of Biochemistry and Molecular Genetics at UAB and co-senior author of the study. “The new genes remodeled the chromosomes that instruct a skin cell to be a skin cell, so that the cells revert to stem cells.”

The researchers then used a DNA fragment engineered by Townes’ laboratory in 2006 to correct the basic sickle mutation in the cells. The corrected iPS cells were then induced to become blood stem cells (capable of making any type of blood cell) and were transplanted back into the diseased mice.

“The new blood stem cells began to function properly, making normal red blood cells that did not sickle,” Townes said. “The animals showed no symptoms of the disease and did not reject the transplanted cells.”

Previous work with iPS cells showed simply that the process worked and skin cells could be transformed into stem cells. Townes and colleague Rudolf Jaenisch, Ph.D., with the Whitehead Institute and a professor of biology at MIT and co-senior author of the study, say this “proof of principle” is the first example of creating iPS cells derived from a disease model and using these cells to correct a genetic mutation and treat a disease.

“These findings are a major step forward in developing a cure for sickle cell anemia,” Townes said. “We anticipate that this therapy will work in humans as it works in mice. And it cured sickle cell in mice.”

There are obstacles to be overcome. The added genes that transform regular cells into iPS cells are delivered by retroviruses and there are inherent risks in the use of retroviruses. The process also uses a cancer gene to stimulate cell division – sort of like a starter for sourdough bread. That gene has to be regulated, so it does not stimulate uncontrolled cell division, potentially causing a risk for cancer.

Townes says researchers are already at work in resolving these issues, although it may be years before iPS is a viable approach to treat disease in humans.

This research was funded by the National Heart, Lung and Blood Institute, one of the National Institutes of Health (NIH).
 
 
 
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