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Recent News and Articles on the Keywords: protects against + disease + lead  Related to the article below (Last Update: 8/5/2008)

Many herbs make move to medicine cabinet
MLive.com, MI -
They also are implemented to protect against contamination problems due to natural toxins, bacteria, pesticides, glass, lead or other substances. ...

TheMedGuru
Want a long life? Control Cholesterol Levels From Childhood
TheMedGuru, India -
A high level of LDL ?bad? cholesterol can be dangerous as it lead to atherosclerosis (hardened arteries ) and coronary arterydefine disease (CAD) and heart ...
Breast cancer: What you need to know
Food Consumer, IL -
Soy: Soy isoflavones may not raise markers for breast cancer in postmenopausal women and could protect them against the disease, suggests an animal study ...
A Farewell To Arms
Slate -
Most already argue against treating the majority of men in that age group for a disease that usually progresses very slowly, but some experts questioned the ...
Meningitis vaccinations urged
Honolulu Star-Bulletin, HI -
Both vaccines protect against four types of bacteria that account for about two-thirds of meningitis cases among college students, according to the ...
Consumer Reports' Finds Some Lead Test Kits Can Be Good First Step ...
MarketWatch -
The Centers for Disease Control and Prevention defines elevated lead levels as 10 micrograms per deciliter of blood, but Consumers Union, the nonprofit ...
Nastech Pharmaceutical Company Inc. Q2 2008 Earnings Call Transcript
Seeking Alpha, NY -
Our platform technology has matured to a point that we can develop siRNA drug candidates against a variety of human diseases with the hope of beginning to ...MRNA
Ghana's AIDS prevalence drops, but no complacency - Prof. Amoa
Ghana News, Ghana - 28 minutes ago
"Ghana is doing very well... we are gradually winning the war against the disease," he said, adding that Ghana could achieve the control target by ...
Fishy diet may protect against clogged arteries
Reuters - Jul 28, 2008
Over time, they harden and narrow the arteries and can lead to serious problems like heart attacks and stroke. "The death rate from coronary heart disease ...

Oneindia
Statins May Protect Against Memory Loss
Science Daily (press release) - Jul 28, 2008
For instance, people with Type 2 diabetes are up to three times more likely to develop Alzheimer's disease, they found. In this current study, Haan's group ...
Cholesterol lowering drugs may protect against dementia News-Medical.net
Statins Lower Risk of Dementia and Memory Loss eMaxHealth.com
Statins "may cut dementia risk" Xinhua
all 79 news articles »
Source: Google News

Cellular Defenses against Unfolded Proteins A Cell Biologist Thinks about Neurodegenerative Diseases -
MY Sherman, AL Goldberg - Neuron, 2001 - Elsevier
... proteins rapidly and does not lead to nonspecific ... HS proteins and thus helps retard
disease progression and ... the HS response may protect against cellular damage ...

… of Neuronal Nitric Oxide Synthase by 7-Nitroindazole Protects Against MPTP-Induced Neurotoxicity in … -
JB Schulz, RT Matthews, MMK Muqit, SE Browne, MF … - J. Neurochem., 1995 - Blackwell Synergy
... changes analogous to those observed in idiopathic Parkinson's disease. ... et al., 1991),
which may lead to partial ... 7-Nitroindazole Protects Against MPTP-Induced ...

… exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among … -
TJ Coffey, MC Enright, M Daniels, JK Morona, R … - Molecular Microbiology, 1998 - Blackwell Synergy
... some illegitimate or transpositional mechanism, lead to these ... conjugate vaccines
that protect against serotype b ... in controlling invasive disease (Murphy et al ...

… Infection with Leishmania major and Vaccinating Against It Protects Against L. major Infection 1 -
RV Morris, CB Shoemaker, JR David, GC Lanzaro, RG … - The Journal of Immunology, 2001 - Am Assoc Immnol
... Leishmania may protect certain individuals but lead to disease exacerbation in others
(2). Thus, novel approaches toward vaccinating against leishmaniasis need ...

Apolipoprotein E-e4 protects against severe liver disease caused by hepatitis C virus -
MA Wozniak, RF Itzhaki, EB Faragher, MW James, SD … - Hepatology, 2002 - doi.wiley.com
Page 1. Apolipoprotein E- 4 Protects Against Severe Liver Disease Caused
by Hepatitis C Virus Matthew A. Wozniak, 1 Ruth F. Itzhaki ...

[PDF] HOW NUCLEOTIDE EXCISION REPAIR PROTECTS AGAINST CANCER -
EC Friedberg - Nature Reviews Cancer, 2001 - nature.com
... in part from our understanding of the phenomenon of DNA repair in normal human
cells,and of a human hereditary disease called xeroderma ... REPAIR PROTECTS AGAINST ...

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal … -
C Grimm, A Wenzel, M Groszer, H Mayser, M Seeliger … - Nature Medicine, 2002 - nature.com
... Epo can directly protect tissues against the deleterious ... against light damage: direct
protection against oxidative stress ... seen in some forms of the disease. ...

Does smoking protect against osteoarthritis? -
DT Felson, JJ Anderson, A Naimark, MT Hannan, WB … - pain - doi.wiley.com
... It appears that smoking or some unidentified factor correlated with smoking modestly
protects against the development of knee OA. ... damage into manifest disease. ...

Interleukin-4 Protects against a Genetically Linked Lupus-like Autoimmune Syndrome -
ML Santiago, L Fossati, C Jacquet, W Muller, S … - Journal of Experimental Medicine, 1997 - Rockefeller Univ Press
... Interleukin-4 Protects against a Genetically Linked Lupus-like ... by IL-4 transgene
expression against this murine SLE ... manifestations of the SLE disease are based ...

Oxygen free radicals linked to many diseases -
JL Marx - Science, 1987 - sciencemag.org
... Linked to Many Diseases ... The therapies now being tested use two enzymes that
normally help to protect cells against superoxide's effects. ...

Source: Google Scholar

Protein protects brain against compound in lead poisoning, liver disease

ANN ARBOR, Mich.---Scientists have discovered that a protein known as PEPT2 protects the brains of mice from a naturally occurring but potentially toxic compound present in lead poisoning and in a class of liver diseases that can cause serious neurological complications.

Scientists at the University of Michigan found that when dosed with the compound called 5-aminolevulinic acid (5-ALA), mice without the PEPT2 protein died sooner, had neuromuscular dysfunction, and had up to 30 times higher concentrations of the toxic compound in their cerebrospinal fluid than did mice with the PEPT2.

PEPT2 is part of a class of membrane proteins called transporter proteins. The research focuses on understanding how these proteins work so that eventually, transporter proteins can be used to deliver different compounds to or from areas of the body in order to help fight diseases such as cancer.

"The findings suggest that the PEPT2 protein could work the same way in humans," said David Smith, U-M professor and chair of pharmaceutical sciences. "If that is the case, then PEPT2 may have relevance as a secondary genetic modifier of conditions such as acute hepatic porphyrias and lead poisoning, and in drug transport at the blood-brain barrier.

"We are looking at how to use the body's own machinery to get the compounds to where we want them to go," Smith said.

Naturally occurring in the body, the acid is involved in forming a substance called heme, which is a component of hemoglobin as well as many important enzymes. If there is an accumulation or an overproduction of 5-ALA in the body, however, it can become toxic. High concentrations of 5-ALA are present in people who have lead poisoning or hepatic porphyrias.

###

Smith's co authors on the paper, which appears in the December issue of the Journal of Neurochemistry, include Yongjun Hu, Hong Shen, pharmaceutical sciences and Upjohn Center for Clinical Pharmacology; and Richard Keep, departments of neurosurgery and molecular and integrative physiology.

For more on Smith, visit: http://sitemaker.umich.edu/pharmaceuticalsciences/pharmsci/david_e._smith

To access the paper, see: http://www.ncbi.nlm.nih.gov/sites/entrez

 
 
 
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