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Recent News and Articles on the Keywords: breast cancer + widely used + cancer  Related to the article below (Last Update: 7/1/2008)

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Source: Google News

Dose and Dose Intensity of Adjuvant Chemotherapy for Stage II, Node-Positive Breast Carcinoma -
WC Wood, DR Budman, AH Korzun, MR Cooper, J … - New England Journal of Medicine, 1994 - content.nejm.org
... Background Adjuvant chemotherapy is widely used for breast cancer and is
known to extend survival. Some clinicians seek a greater ...

Outcome of primary breast cancer patients with micrometastases: a long-term follow-up study -
JL Mansi, H Gogas, JM Bliss, JC Gazet, U Berger, … - feedback, 2005 - biomedcentral.com
... Although the widely used tumour-nodes-metastasis (TNM) staging system is generally
regarded as an effective prognostic index for breast cancer, the search ...

Meeting Highlights: International Consensus Panel on the Treatment of Primary Breast Cancer -
A Goldhirsch, JH Glick, RD Gelber, AS Coates, HJ … - Journal of Clinical Oncology, 2001 - jco.ascopubs.org
... paclitaxel, as part of a standard adjuvant therapy for node-positive breast cancer. ...
Despite the fact that tamoxifen has been widely used for almost three ...

Multicenter Phase II Study of Capecitabine in Paclitaxel-Refractory Metastatic Breast Cancer -
JL Blum, SE Jones, AU Buzdar, PM LoRusso, I Kuter, … - Journal of Clinical Oncology, 1999 - jcojournal.org
... locoregional control, and adjuvant therapy, recurrent metastatic breast cancer remains
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… Thromboembolic Morbidity Among Postmenopausal Women With Early Stage Breast Cancer in a Randomized … -
LE Rutqvist - jnci, 1993 - jnci.oxfordjournals.org
... BACKGROUND: Tamoxifen, which binds to estrogen receptors, is widely used as
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… in Postmenopausal Women After Five Years of Tamoxifen Therapy for Early-Stage Breast Cancer. -
PE Goss, JN Ingle, S Martino, NJ Robert, HB Muss, … - Obstetrical & Gynecological Survey, 2004 - obgynsurvey.com
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UK and USA breast cancer deaths down 25% in year 2000 at ages 20?69 years -
R Peto, J Boreham, M Clarke, C Davies, V Beral - The Lancet, 2000 - Elsevier
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Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen -
KB Horwitz - Endocrinology, 1978 - Endocrine Soc
... Estrogen antagonists are widely used in the treatment of breast cancer, and studies
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… Chemotherapy for Invasive Breast Cancer: National Surgical Adjuvant Breast and Bowel Project … -
S Paik, J Bryant, E Tan-Chiu, G Yothers, C Park, … - jnci, 2000 - jnci.oxfordjournals.org
... to provide clinically relevant comparisons relating directly to treatment decisions
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Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer -
Y Wang, JGM Klijn, Y Zhang, AM Sieuwerts, MP Look, … - The Lancet, 2005 - Elsevier
... 60?70% of patients with lymph-node-negative breast cancer are cured by local or
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Source: Google Scholar

Widely used chemical may raise breast cancer risk

Last Updated: 2007-12-06 10:30:21 -0400 (Reuters Health)

By Anthony J. Brown, MD

NEW YORK (Reuters Health) - The results of an animal study suggest that infants exposed to BBP, a chemical additive used in pipes, vinyl floor tiles, carpet-backing, and other household items, may affect mammary gland development and perhaps increase the susceptibility to breast cancer. BBP (n-butyl benzyl phthalate) is a "plasticizer," which is added to substances such as cement, concrete and clay to increase fluidity.

This study is the first "demonstrating that exposure to this compound soon after birth results in alterations in the expression of genes present in the mammary gland," senior author Dr. Jose Russo, from Fox Chase Cancer Center in Philadelphia, told Reuters Health.

"Our findings are unique in the sense that we are studying the lifetime effect of BBP on the mammary gland, long before it starts developing under the influence of the hormones of puberty," he added. Russo's group originally observed genetic changes induced by BBP that occur very early in life, which may "result in significant modifications in the risk of the mammary gland to develop cancer later on in life."

As reported in the online issue of BMC Genomics, the researchers fed BBP to lactating rats, and their offspring absorbed the chemical in breast milk. According to the report, the amount of BBP ingested by the offspring was roughly equivalent to the safe dose limit for humans established by the Environmental Protection Agency.

BBP exposure increased the uterine and body weight ratio in female offspring and decreased the body weight.

Although exposure to the chemical did not affect the appearance of the mammary gland, it did increase the proliferation of cells in lobules and other breast tissue compartments. Genetic analysis revealed that BBP exposure also increased the expression of several genes related to cell proliferation and differentiation, communication, and signal transduction.

Many of these effects seemed to disappear after BBP exposure was removed; however, the subtle genetic changes may have a lasting effect, the report indicates.

"The take-home message is that for preventing breast cancer in adulthood it is necessary to protect both the newborn child and the mother from exposure." BBP has an effect on estrogen and may disrupt hormone production, Russo emphasized.

His group is currently conducting studies to evaluate the influence of these early changes in gene expression induced by BBP and the response of breast tissue to exposure to chemical carcinogens later in life, he added.

SOURCE: BMC Genomics, December 5, 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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