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Recent News and Articles on the Keywords: esophageal cancer + black raspberries + cancer  Related to the article below (Last Update: 5/5/2008)

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… of Esophageal Tumorigenesis by Dietary Administration of Lyophilized Black Raspberries 1 -
LA Kresty, MA Morse, C Morgan, PS Carlton, J Lu, A … - Cancer Research, 2001 - AACR
... including esophageal cancer. We have taken a "food-based" chemopreventive approach
to evaluate the inhibitory potential of lyophilized black raspberries (LBRs ...

… -induced Transactivation of Activated Protein 1 and Nuclear Factor ?B by Black Raspberry Extracts 1 -
C Huang, Y Huang, J Li, W Hu, R Aziz, M Tang, N … - Cancer Research, 2002 - AACR
... shown to inhibit the development of chemically induced esophageal and colon cancer
in rodents.In addition, organic extracts of black raspberries inhibit benzo(a ...

Effects of Lyophilized Black Raspberries on Azoxymethane-Induced Colon Cancer and 8-Hydroxy-2'- … -
GK Harris, A Gupta, RG Nines, LA Kresty, SG Habib, … - Nutrition and Cancer, 2001 - Lawrence Earlbaum
... that lyophilized strawberries inhibit nitrosomethylbenzylamine-induced esophageal
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Inhibition of cellular transformation by berry extracts -
H Xue, RM Aziz, N Sun, JM Cassady, LM Kamendulis, … - Carcinogenesis, 2001 - Oxford Univ Press
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Chemopreventive Properties of Black Raspberries in N-Nitrosomethylbenzylamine-Induced Rat Esophageal … -
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... Thus, black raspberries may be a useful alternative to chemopreventive drugs
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Source: Google Scholar

Black raspberries may prevent cancer of esophagus

Last Updated: 2007-12-06 13:51:52 -0400 (Reuters Health)

By Megan Rauscher

NEW YORK (Reuters Health) - People with chronic irritation of the esophagus caused by the backup of stomach acid - a condition known as Barrett's esophagus -- may benefit from incorporating black raspberries into their diet, suggest research findings reported today during the Sixth Annual International Conference on Frontiers in Cancer Prevention, sponsored by the American Association for Cancer Research.

People with Barrett's esophagus have a 30- to 40-fold increased risk of developing cancer of the esophagus, a deadly cancer with poor survival, Dr. Laura A. Kresty from Ohio State University, Columbia, told the conference members.

It's been shown previously that adding antioxidant-packed black raspberries to the diet of animals inhibits the development of chemically induced cancer of the mouth, esophagus and colon, chiefly by decreasing DNA damage, cancerous cell growth and markers of harmful oxidative stress. Patients with Barrett's esophagus are "under increased oxidative stress," Kresty explained.

Against this backdrop, she and colleagues had 20 men and women with Barrett's esophagus eat 32 or 45 grams (female and male, respectively) of concentrated freeze-dried black raspberries daily for 26 weeks. "This composition of black raspberries is high in antioxidants, as well as vitamins, minerals and fiber," Kresty noted.

After 26 weeks, the patients experienced a statistically significant decline in average levels of 8-Isoprostane in urine - a marker for oxidative stress - as well as in DNA damage - two processes linked to the development of Barrett's esophagus and progression to cancer of the esophagus.

Moreover, in 37 percent of patients, the black raspberry regimen also led to an increase in expression of tissue levels of a key enzyme called GSTpi, which detoxifies cancer-causing compounds. This enzyme is often reduced in irritated Barrett's tissue compared with the levels found in normal healthy tissue.

The findings, Kresty said, show that "patients can do something to modify cancer pathways."

Dr. William G. Nelson, of Johns Hopkins in Baltimore, who moderated a press conference on diet and cancer prevention, agrees. "The diet is one of the great modifiable risk factors" for the development of cancer, he said.

"You eat about a pound and a half of food a day," he said, "and it's an incredibly complicated chemical mixture so, in that sense, it is not surprising that there might be things that you can encounter in the diet that might be harmful and other things that might be helpful and protective and preventive."

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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