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Recent News and Articles on the Keywords: combat asthma + asthma + off  Related to the article below (Last Update: 5/5/2008)

14 Allergy Strategies That Bring Fast Relief
RedOrbit, TX - May 2, 2008
"They are effective for a number of years, and they can even prevent the development of other allergies as well as asthma."
In war against dust mites, there?s no winning
MSNBC - Apr 17, 2008
Ever since doctors diagnosed her husband and, later, her oldest daughter, with allergic asthma triggered by dust mites, she has waged war against the ...
Cystic Fibrosis pledge walk scheduled for May 17
Bemidji Pioneer, MN - May 4, 2008
It is also a disease often misdiagnosed as asthma or some other condition that causes difficulty in breathing, Micki said. Like one in 30 Americans, ...

eMilitary.org
The Military Family Network
eMilitary.org - May 2, 2008
As a child, he suffered from asthma attacks and coughing fits that routinely landed him in the hospital, Bush said. But the asthmatic child resolved to wean ...
Ah-Choo! What'll Sufferers Do?
Tampa Tribune, FL - Apr 23, 2008
That's because 83 percent of you say you'll never get rid of your pet, according to the American Academy of Allergy, Asthma and Immunology. ...
Report: Leon county second-worst in state for air quality
Tallahassee Democrat, FL - Apr 30, 2008
The tiny particles can cause serious health problems, said Dr. Ronald Saff, a Tallahassee allergy and asthma specialist. "The scary thing is that people are ...
Do sandstorms make you cry?
Kuwait Times, Kuwait - Apr 10, 2008
According to quack doctors, pill number 1 (generic name: grilled lizard) is the best medicine to combat asthma. But the symptoms may persist even after you ...
The War Within: Post-traumatic stress disorder
Belleville News Democrat,  USA - Apr 27, 2008
He compared the treatment to treatments for asthma. In both cases, he said, patients work to make "the symptoms to go away and to prevent them from coming ...
Leave Bedroom Allergens High and Dry This Spring!
CNNMoney.com (press release) - Apr 10, 2008
The Asthma and Allergy Foundation of America is the leading nonprofit consumer and patient organization fighting asthma and allergic diseases. ...
Dave Albee: Hall of Fame induction a meaningful honor for swimmer
Marin Independent-Journal, CA - Apr 19, 2008
DeMont, a chronic asthma sufferer, had been prescribed Marax tablets (which contained a sedative, according to his mother) two years earlier to combat ...
Source: Google News

The size of the problem of managing asthma -
PJ Barnes - Respiratory Medicine, 2004 - Elsevier
... of highly effective medication to combat asthma symptoms and ... 7% reported overnight
hospitalisation due to asthma and 17% reported taking time off work due to ...

Enhancing care for people with asthma: the role of communication, education, training and self- … -
MR Partridge, SR Hill - European Respiratory Journal, 2000 - Blackwell Synergy
... Implementation Plan. This is a 4 yr plan to sustain the progress made so far
and accelerate current efforts to combat asthma. The focus ...

Combining Community-Based Research and Local Knowledge to Confront Asthma and Subsistence-Fishing … -
J Corburn - Environmental Health Perspectives, 2002 - JSTOR
... health surveys and related action to combat asthma (23 ... El Puente's work appears to
be paying off; not only ... of community members in their asthma mastery program ...

No Symptoms, No Asthma* The Acute Episodic Disease Belief Is Associated With Poor Self-Management … -
EA Halm, P Mora, H Leventhal - Chest, 2006 - Am Coll Chest Phys
... a day, whether you are feeling good or bad, to help cool off the inflammation in ...
Conference proceedings: working together to combat urban asthma 1998 New ...

Asthma and pregnancy -
JGW BURDON, G GOSS - Internal Medicine Journal, 1994 - Blackwell Synergy
... curve are found in the foetal physiology to combat these potentially ... 29% of patients
experience an improvement in their asthma, 22% are worse off and 49 ...

Influence of Asthma or Allergies on the Utilization of Health Care Resources and Quality of Life of … -
LM Jolicoeur, D Pharm, JG Boyer, CE Reeder, J … - Journal of Asthma, 1994 - informaworld.com
... were developed and im- plemented to combat further increases ... were women and 56 (73%)
reported living off campus ... reporting a diag- nosis of ?asthma only? was ...

Sudden Deaths from Asthma Physiopathological Mechanisms; Report of a Case -
D LEIGH - Psychosomatic Medicine, 1955 - Am Psychosomatic Soc
... She was rushed off to the hospital ... acute emotional disturbance and an attack of asthma
is often ... anxiety ex- perienced by flying personnel during combat missions ...

POPULATION DISPARITIES IN ASTHMA -
DR Gold, R Wright - Annual Review of Public Health, 2005 - Annual Reviews
... POPULATION DISPARITIES IN ASTHMA. ... Abstract The prevalence of asthma in the United
States is higher than in many other countries in the world. ...

A Pilot Study of the Multidisciplinary Management of Childhood Asthma in a Family Practice -
MA Weingarten, J Goldberg, Y Teperberg, N Harrison … - Journal of Asthma, 1985 - informaworld.com
... She found that a certain game set off an asth- matic attack ... aspect of our approach
is that we tried to combat some of the adverse conse- quences of asthma. ...

8. Occupational asthma and allergies -
EJ Bardana - The Journal of Allergy and Clinical Immunology, 2003 - Elsevier
... workplace. More than 250 chemicals have been incriminated as a cause of occupational
asthma (OA). ... asthma. 11 8. Occupational asthma and allergies ...

Source: Google Scholar

HATS Off To Combat Asthma
Two University of Nottingham studies exploring the causes and treatment of asthma and Chronic Obstructive Pulmonary Disease (COPD) could lead to the development of drugs to battle these debilitating conditions.

The Division of Respiratory Medicine at the University has been awarded a total of £1.24m in grants to study respiratory disease. The Wellcome Trust has awarded Prof Alan Knox and Dr Linhua Pang £700,000 to research transcriptional control of inflammatory gene expression in asthma - allowing the team to examine the part inflammatory mediators play in the way asthma sufferers react to allergens. A second grant of £540,000 from MRC to Prof Knox and his colleagues Prof Peter Fischer and Prof David Heery will explore histone acetyl transferase (HAT) inhibitors in asthma and COPD. This study will investigate a bank of plant extracts at the University of Strathclyde, seeking compounds that could combat the intercellular processes that result in the symptoms of asthma and COPD - inflammation of the airways which can lead to coughing, breathlessness and increased chest infections.

Though they are different diseases, asthma and COPD affect the human body in a similar way. In asthma, allergens irritate the lungs, in COPD, this is done by cigarette smoke. This irritation inflames the sufferer's airways, which the muscles then close, creating a narrowing effect.
Research done at the University over the past 15 years has found that the muscle layer in the airway is more complex than has traditionally been thought. As well as going into spasm during asthma and COPD attacks the muscle layer produces a wide range of mediators and cytokines - proteins that act as chemical signallers when it comes into contact with allergens or cigarette smoke. In asthma and COPD sufferers, these proteins are produced by stimulation of airway muscle cell walls in the lungs, releasing intracellular signalling proteins called 'transcription factors' which alter the DNA of the cell and activate messenger RNA. It is these 'transcription factors' which activate the inflammation by causing release of mediators and cytokines.

The activation status of these transcription factors is determined by the balance between two competing groups of enzymes called histone acetyl transferase (HATs) and histone deacetylases (HDACs). In asthma and COPD sufferers the balance is altered so that the HATs are activated and HDACs suppressed with the result that inflammation is switched on. The investigators at the University think that if the balance could be restored by inactivating HATs then the mediators and cytokines will be switched off and inflammation dampened down.

By exploring plant extracts that may reduce the activation of HATs within airway cells, the researchers may isolate compounds that could be used to suppress inflammation in respiratory disease. Any drug successfully synthesised from such compounds could potentially revolutionise the treatment of respiratory disease. There is also the potential to treat other inflammatory diseases, such as rheumatoid arthritis and Inflammatory Bowel Disease.

Professor Alan Knox, of the Division of Respiratory Medicine at the University, said: "The majority of people with asthma have access to reasonably good anti-inflammatory treatments that can keep their conditions under control. But up to 20 per cent of sufferers don't respond well to the treatments currently available. And when it comes to COPD, anti-inflammatory drugs aren't very effective.

"By tracking the process which triggers the inflammation and then identifying the compounds that inhibit or activate these crucial enzymes, we could put into motion the development of a drug which could have a huge impact on the lives of those suffering from respiratory and other inflammatory diseases."

Notes: The University of Nottingham undertakes world-changing research, provides innovative teaching and a student experience of the highest quality. Ranked by Newsweek in the world's Top 75 universities, its academics have won two Nobel Prizes since 2003. The University is an international institution with campuses in the United Kingdom, Malaysia and China.

More information is available from Professor Alan Knox or Tara de Cozar, Internal Communications Manager in the Communications Office at The University of Nottingham, http://www.nottingham.ac.uk/.

Source:
Alan Knox
University of Nottingham
 
 
 
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