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Recent News and Articles on the Keywords: us study + u.s. study + mice  Related to the article below (Last Update: 5/5/2008)

Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical ...
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The objective of this dose-ranging study is to support dose selection for Phase 3, and to inform the ongoing development of a convenient delivery system for ...AMLN
Study Gives Whole New Meaning To 'Computer Virus'
Consumer Affairs -
A study by a British microbiologist suggests computer keyboards and mice can collect lots of germs and transmit them to everyone who uses them. ...
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One multi-center study, which involved more than 3800 elderly persons, found significantly greater antibody responses a month after vaccination among those ...
Covering ground
Centre Daily Times, PA - May 4, 2008
A statewide study on fisher disease and food habits will conclude this summer, and another population study is about to begin in the Allegheny National ...
A rising star
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There are also Fulbright post-doctoral fellowships in all fields of study for Israelis who are about to begin a program of research in the US. ...
Criticism mounts over ingredient in plastics
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A 2003-04 study by the US Centers for Disease Control and Prevention found detectable levels of BPA in 93 percent of 2517 urine samples from people aged 6 ...
Curcumin may offer diabetes benefits: study
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In the US, there are over 20 million people with diabetes, equal to seven per cent of the population. The total costs are thought to be as much as $132 ...

AFP
Human protein could help AIDS fight: study
AFP - Apr 28, 2008
... against HIV/AIDS by offering scientists a way to attack the virus and avoid problems with drug resistance, according to a US study released Monday. ...
Mice Can Sense Oxygen Through Their Skin
Science Daily (press release) - Apr 17, 2008
The mutants we used in our study have high EPO levels and high red blood cell counts. But they don't have inflammation. The next step for us is going to be ...
Exercise Worsened Prostate Cancer in Mice, Researchers Find
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The study was funded by the US Department of Defense, the Prostate Cancer Foundation and the American Urological Association Foundation. ...
Source: Google News

… -induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study. -
JC Lotz, OK Colliou, JR Chin, NA Duncan, E … - Spine, 1998 - ncbi.nlm.nih.gov
... Surgery, University of California, San Francisco, California, USA. ... finite element
model used in this study predicts loss ... Types: Research Support, Non-US Gov't. ...

Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. -
JR Sanes, JL Rubenstein, JF Nicolas - The EMBO Journal, 1986 - pubmedcentral.nih.gov
... Proc Natl Acad Sci US A. 1972 Jan;69(1):258?263 ... A phase and electron microscopic
study of vasculogenesis and erythropoiesis in the yolk sac of the mouse. ...

Non-Melanoma Skin Cancer Occurring in Patients Treated With PUVA Five to Ten Years After First … -
… , R Lange, M Photochemotherapy Follow-up Study - Journal of Investigative Dermatology, 1988 - nature.com
... Harvard School of Public Health, Boston, Massachusetts, USA. ... Incidence of nonmelanoma
skin cancer in the United States. 1983 US Department of Health and Human ...

A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the … -
FS vom Saal, PS Cooke, DL Buchanan, P Palanza, KA … - Toxicol Ind Health, 1998 - ncbi.nlm.nih.gov
... physiologically based approach to the study of bisphenol ... Biological Sciences, University
of Missouri, Columbia 65211, USA. ... in male offspring of mice fed these ...

Safety and antitumor activity of recombinant soluble Apo2 ligand -
A Ashkenazi, RC Pai, S Fong, S Leung, DA Lawrence, … - Journal of Clinical Investigation, 1999 - pubmedcentral.nih.gov
... Cancer cell lines developed at the US National Cancer ... cells were obtained from Clonetics,
San Diego, California, USA. Study of Apo2L safety in nonhuman primates ...

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated … -
DC Angus, WT Linde-Zwirble, J Lidicker, G Clermont … - Critical Care Medicine, 2001 - ccmjournal.com
... cost, and outcome of severe sepsis in the United States. Design: Observational cohort
study. Setting: All nonfederal hospitals (n = 847) in seven US states. ...

study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women -
S Liu, WC Willett, MJ Stampfer, FB Hu, M Franz, L … - American Journal of Clinical Nutrition, 2000 - Am Soc Nutrition
... and risk of coronary heart disease in US women 1 ... and Insulin Resistance: The Inter99
study Diabetes Care ... of Obesity in Agouti Transgenic Mice Obesity, January 1 ...

… in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive … -
Y Berthois, JA Katzenellenbogen, BS … - Proc Natl Acad Sci US A, 1986 - pubmedcentral.nih.gov
... a weak estrogen: implications concerning the study of estrogen ... Proc Natl Acad Sci
US A. 1983 Jun;80 ... National Academy of Sciences of the United States of America ...

… to 10 Oral Antimicrobial Agents Based on Pharmacodynamic Parameters: 1997 US Surveillance Study -
MR Jacobs, S Bajaksouzian, A Zilles, G Lin, GA … - Antimicrobial Agents and Chemotherapy, 1999 - aac.highwire.org
... of bacterial respiratory pathogens from US medical centers ... from outpatients in the
United States during the ... a 1992-93 Western Europe and USA collaborative study ...

Neocortical histogenesis in normal and reeler mice: a developmental study based upon [3H] thymidine …
VS Caviness Jr - Brain Res, 1982 - ncbi.nlm.nih.gov
... normal and reeler mice: a developmental study based upon ... neocortex are inverted in
the reeler mutant mouse. ... Publication Types: Research Support, US Gov't, PHS. ...

Source: Google Scholar

Protein turns up metabolism in mice - U.S. study

Last Updated: 2007-12-05 13:01:04 -0400 (Reuters Health)

CHICAGO - Tricking muscle tissue to burn rather than store fat has succeeded in increasing the average life span of mice and staved off some age-related diseases, U.S. researchers said on Tuesday.

Mice bred to make too much of a protein known as uncoupling protein 1 released food energy as heat instead of storing it as fat.

"What we're uncoupling is the process of burning energy from storing energy," said Dr. Clay Semenkovich of Washington University School of Medicine in St. Louis, Missouri whose research appears in the journal Cell Metabolism.

"Normally when you metabolize food, you take the energy that comes from that food and you store it. In essence, you are coupling the energy in the food into a stored form," Semenkovich said in a telephone interview.

Mice that overproduced this uncoupling protein in their muscle tissue weighed less and had less fat tissue, even though they ate the same amount as normal mice in the study.

"They lived about three months longer on average, which translates into six or seven years in human life, which is pretty good," Semenkovich said.

The protein did not extend the maximum life span of the mice, but it did increase their average life span, perhaps because they were less prone to age-related diseases, Semenkovich said.

Mice in the study had a lower incidence of vascular disease, hypertension and lymphoma, a type of cancer.

Semenkovich said these same uncoupling proteins occur in humans, and genetic variations in the proteins have been linked with people weighing more or less.

"It may be possible to accelerate metabolism and find an alternative way of treating diseases," he said.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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