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Recent News and Articles on the Keywords: alcohol consumption + influence alcohol + gene  Related to the article below (Last Update: 5/13/2008)


eFluxMedia
Alcohol linked to increased risk of invasive breast cancer
Food Consumer, IL - Apr 14, 2008
Many epidemiologic studies have linked alcohol consumption to increased risk of breast cancer. Laboratory studies have demonstrated that alcohol increases ...
How What and How Much We Eat (And Drink) Affects Our Risk of Cancer Newswise (press release)
all 194 news articles »  OTC:CTHP
Association between single nucleotide polymorphisms in the mu ...
7thSpace Interactive (press release), NY - Apr 23, 2008
These data further suggest that making conclusions on the role of the mu opioid receptor gene in the development of alcohol dependence may be limited if ...
Systems Biology in the Study of Neurological Disorders: Focus on ...
RedOrbit, TX - Apr 30, 2008
One of the organs most severely affected by excessive alcohol consumption is the brain, and long-term heavy drinking has serious detrimental effects on ...
Alzheimer?s battle of sexes
Irish Independent, Ireland - May 8, 2008
According to the investigators, novel risk factors for impaired cognition were recent anaesthesia, a lower consumption of caffeine, tobacco and alcohol, ...
Alzheimer's disease risks are gender specific
National Post, Canada - May 7, 2008
According to the investigators, novel risk factors for impaired cognition were recent anesthesia, less consumption of caffeine, tobacco and alcohol, ...
Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment ...
RedOrbit, TX - May 3, 2008
Alcohol consumption and risk of lung cancer a pooled analysis of cohort studies. AmJCHn Nutr. 2005; 82(3):657-667. 18. Lee IM. Physical activity and cancer ...
Source: Google News

… Gene Variation and Rearing Condition in Alcohol Preference and Consumption in Female Primates -
CS Barr, TK Newman, S Lindell, C Shannon, M … - Archives of General Psychiatry, 2004 - archpsyc.highwire.org
... wanted to determine whether serotonin transporter gene variation and rearing condition
would influence changes in the patterns of alcohol consumption across a 6 ...
-

Alcohol consumption by orientals in North America is predicted largely by a single gene -
GC Tu, Y Israel - Behavior Genetics, 1995 - Springer
... if protection by this gene deficiency exists ... study we have determined the influence
of ALDH2 ... North American society on alcohol consumption, excessive consumption ...

… between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of … -
K Matsuo, N Hamajima, M Shinoda, S Hatooka, M … - Carcinogenesis, 2001 - Oxford Univ Press
... protective effects of reducing alcohol consumption may be ... and Ishii,H. (1999) Alcohol
and aldehyde dehydrogenase gene polymorphisms influence susceptibility to ...

Alcohol and Aldehyde Dehydrogenase Gene Polymorphisms Influence Susceptibility to Esophageal Cancer … -
A Yokoyama, T Muramatsu, T Omori, S Matsushita, H … - Alcoholism: Clinical and Experimental Research, 1999 - Blackwell Synergy
... Polymorphisms Influence Susceptibility to Esophageal ... for the highest risk gene
combination (ADH2*1 ... subjects, without adjustment for alcohol consumption (Hori et ...

Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and … -
A Yokoyama, T Muramatsu, T Omori, T Yokoyama, S … - Carcinogenesis, 2001 - Oxford Univ Press
... great influence of gene polymorphisms may be related to the study population's
homogeneity with regard to their extremely high alcohol consumption. ...

The DRD4 VNTR polymorphism moderates craving after alcohol consumption -
KE Hutchison, J McGeary, A Smolen, A Bryan, RM … - Health Psychol, 2002 - content.apa.org
... 0278-6133.21.2.139 Keywords alcohol consumption; craving; gene ... Temperance board
registration for alcohol abuse in ... with nicotine: The modifying influence of the ...

The influence of alcohol consumption on worldwide trends in mortality from upper aerodigestive tract … -
GJ Macfarlane, TV Macfarlane, AB Lowenfels - British Medical Journal, 1996 - jech.bmj.com
... The influence of alcohol consumption on worldwide trends in mortality from ... countries,
reversing the trend of increases in consumption of alcohol has the ...

The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption -
R Spanagel, G Pendyala, C Abarca, T Zghoul, C … - Nature Medicine, 2004 - nature.com
... our findings support the results of the studies in Per2 mutant mice and suggest
a role for the PER2 gene in the regulation of alcohol consumption in humans. ...

Alcohol Dehydrogenase Polymorphisms Influence Alcohol-Elimination Rates in a Male Jewish Population. -
YD Neumark, Y Friedlander, R Durst, E Leitersdorf, … - Alcoholism: Clinical and Experimental Research, 2004 - alcoholism-cer.com
... but it is clear that the influence of the ... ADH2*2 allele with reduced ethanol consumption
in Jewish ... of allelic variations in human alcohol dehydrogenase gene ...

Serotonin Transporter Gene Variation is Associated with Alcohol Sensitivity in Rhesus Macaques … -
CS Barr, TK Newman, ML Becker, M Champoux, KP … - Alcoholism: Clinical and Experimental Research, 2003 - alcoholism-cer.com
... Early experience and serotonin transporter gene variation interact to influence
primate CNS ... CN, Schafer GL (1996) Elevated alcohol consumption in null ...

Source: Google Scholar

Scientists identify gene that influences alcohol consumption

A variant of a gene involved in communication among brain cells has a direct influence on alcohol consumption in mice, according to a new study by scientists supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH), and the U.S. Army.

Scientists do not know yet whether a similar gene variant, with a similar effect on alcohol consumption, exists in humans.

Known as Grm7, the gene encodes a receptor subtype that inhibits the release of glutamate and other neurotransmitter molecules that brain cells use to communicate with one another. Researchers identified a gene variant, or polymorphism, that reduces the abundance of Grm7 messenger RNA (mRNA) in brain tissue. mRNA is the molecular intermediate between a gene and its protein product. Mice that possess this gene variant drink more alcohol than do mice with higher brain levels of Grm7 mRNA. A report of the study appears as an online Article in Press in Genomics.

“This is a noteworthy contribution, particularly since identifying genes that predispose to alcohol-related behaviors is such an arduous task,” says NIAAA Director Ting-Kai Li, M.D.

Scientists have long known that genes account for a significant proportion of the risk for alcoholism. However, the fact that there are multiple such genes that interact with each other and with multiple environmental factors to influence drinking behavior has hampered studies aimed at isolating individual genes.

“Controlling for this background noise -- the various gene-gene and gene-environment interactions -- presents considerable methodological challenges,” notes first author Csaba Vadasz, Ph.D., professor of psychiatric research in the department of psychiatry at New York University School of Medicine, and Director of the NeuroBehavioral Genetic Research Program at the Nathan Kline Institute in Orangeburg, N.Y.

To overcome these difficulties, Dr. Vadasz and colleagues applied a variety of genetic and analytic techniques to animals having nearly identical genetic background, but differing in their preference for alcohol, to identify a chromosomal region, and ultimately the Grm7 gene, associated with alcohol preference.

“Our findings support emerging evidence of the critical role that the brain’s glutamate pathways play in addiction,” says Dr. Vadasz. “While dopamine has traditionally been cast as a central actor in the neurochemistry of substance use and abuse, recent studies indicate that glutamate systems play an important role in reinforcement and addiction.”

If further studies show that a similar gene variant is relevant to alcohol problems in humans, the finding by Dr. Vadasz and colleagues may lead to new opportunities for developing drugs to treat alcohol dependence. Dr. Vadasz speculates that such drugs might be designed to control the level of the Grm7 gene product or modulate the activity of the gene product itself.

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The National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health, is the primary U.S. agency for conducting and supporting research on the causes, consequences, prevention, and treatment of alcohol abuse, alcoholism, and alcohol problems and disseminates research findings to general, professional, and academic audiences. Additional alcohol research information and publications are available at www.niaaa.nih.gov.

The National Institutes of Health (NIH) — The Nation's Medical Research Agency — includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary Federal agency for conducting and supporting basic, clinical, and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.
 
 
 
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