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Recent News and Articles on the Keywords: stem cell + stem cells + aging  Related to the article below (Last Update: 5/12/2008)


KCBS
Bay Area bids for stem cell bonanza
San Francisco Chronicle,  USA - May 6, 2008
... of stem cell science, investigating how cells derived from human embryos might be coaxed to regenerate tissues damaged by trauma, disease or aging. ...
Buck gets $20.5 million for stem cell research lab Marin Independent-Journal
Buck Institute in Novato to get $20.5 million for stem cell lab Santa Rosa Press Democrat
BUCK CENTER PLANS TO GROW Novato Advance
all 162 news articles »
Embryonic Stem Cells Turned Into Three Types of Heart Cells
Washington Post, United States - Apr 23, 2008
"Now we have our hands on a cell that doesn't have the same developmental potential as embryonic stem cells but can still make three of the major types of ...
Skincare Research Revolution: Amatokin Skin Care Research Goes to ...
PR Web (press release), WA - May 7, 2008
Polypeptide #153 takes advantage of underutilized adult stem cells and stimulates them to create new skin cells. So, it uses the body's stem cell reservoirs ...
National Stem Cell exploits anti-aging qualities of stem cells
CosmeticsDesign.com, France - Apr 24, 2008
National Stem Cell's subsidiary Decouverte Cosmetique is producing anti-aging products that incorporate tropelastin secreted from human embryonic stem cells ...OTC:NHGI

Inventorspot
Aging Skin? A New Stem Cell Rejuvenation Cream In The Pipeline
Inventorspot - Apr 30, 2008
RNL Bio says that its new cream, derived from stem cells of human placentas, will encourage faster regeneration of skin cells than its predecessors. ...
Fazlur Rahman: Stem cell research is key piece of global science
Dallas Morning News, TX - Apr 21, 2008
Blood and bone marrow stem cell therapy is a lifesaver for patients with hematologic cancers. Experimental treatments with these cells also ameliorate ...

Los Angeles Times
Scientists weigh in on skin creams and their claims of harnessing ...
Los Angeles Times, CA - Apr 18, 2008
MARKETING: Some skin creams describe their products as stem -cell technology; others try to stimulate skin rejuvenation. Skin creams tout stem cells' ...
Inflammation Triggers Cell Fusions That Could Protect Neurons ...
Science Daily (press release) - Apr 20, 2008
Although the progeny of these hematopoietic stem cells have previously been shown to fuse with a variety of other cell types in the body, this fusion occurs ...
Alzheimer's Disease Brings Burdens to Patients and Their Families
RedOrbit, TX -
There is also research being done with nerve growth cell factor and stem cell growth. "Stem cell growth is probably the best hope for the future, ...
Bra Wonder Without Silicon - Thanks to Stem Cell Concentrated Own-Fat
PR Newswire UK (press release), UK - Apr 29, 2008
Karl-Georg Heinrich, an expert in aesthetic medicine and anti-aging, is the first to offer this method in Europe. "Breast Augmentation with stem cells for ...
Source: Google News

Multilineage Potential of Adult Human Mesenchymal Stem Cells -
MF Pittenger, AM Mackay, SC Beck, RK Jaiswal, R … - Science, 1999 - sciencemag.org
... found in embryonic germ layers (1). Many adult tissues contain populations of stem
cells that have the capacity for renewal after trauma, disease, or aging. ...

The aging of hematopoietic stem cells -
SJ Morrison, AM Wandycz, K Akashi, A Globerson, IL … - Nature Medicine, 1996 - nature.com
... The aging of hematopoietic stem cells. ... | PubMed | ISI | ChemPort |; Harrison, DE
Proliferative capacity of erythropoietic stem cell lines and aging: An overview. ...

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. -
H Vaziri, W Dragowska, RC Allsopp, TE Thomas, CB … - Proceedings of the National Academy of Sciences of the …, 1994 - pubmedcentral.nih.gov
... organization and the study of cellular aging. J Exp Med. 1982 Feb 1;155(2):432?444.
[PubMed]; Harrison DE, Astle CM. Loss of stem cell repopulating ability ...

Pluripotency of mesenchymal stem cells derived from adult marrow -
Y Jiang, BN Jahagirdar, RL Reinhardt, RE Schwartz, … - Nature, 2002 - nature.com
... may not expect significant contribution of stem cells to these ... weeks, as is commonly
seen in aging NOD/SCID ... Although the B-cell lymphoma was host-derived (CD19 ...

Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues -
DJ Prockop - Science, 1997 - sciencemag.org
... marrow is partially replaced by adipose tissue with aging. ... Sutherland, A. K. Stewart,
A. Keating, Stem Cells (Dayton) 11 ... 50 (1993); T. Otsuka, et al., J. Cell. ...

Mammalian Neural Stem Cells -
FH Gage - Science, 2000 - sciencemag.org
... What are the mechanisms that determine whether a stem cell will divide symmetrically ...
Cell. ... work was funded by the National Institute on Aging, the Christopher ...

… frequency and proliferation of hematopoietic stem cells during aging: correlation between lifespan … -
G de Haan, W Nijhof, G Van Zant - Blood, 1997 - ncbi.nlm.nih.gov
... read Mouse strain-dependent changes in frequency and proliferation of hematopoietic
stem cells during aging: correlation between lifespan and cycling activity. ...

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt -
CS Potten - Development, 1990 - dev.biologists.org
... KD Siegmund, RM Liskay, and D. Shibata Diet, cancer and aging in DNA ... O. Bonham-Carter,
and OA Runquist Computer Modeling Implicates Stem Cell Overproduction in ...

Derivation of Completely Cell Culture-Derived Mice from Early-Passage Embryonic Stem Cells -
A Nagy, J Rossant, R Nagy, W Abramow-Newerly, JC … - Proceedings of the National Academy of Sciences of the …, 1993 - JSTOR
... They do not show any signs of premature aging or tumor development ... possi- bility
is that ES cells are not able to replicate exactly their stem-cell state during ...

Dynamic changes in mouse hematopoietic stem cell numbers during aging. -
G de Haan, G Van Zant - Blood, 1999 - ncbi.nlm.nih.gov
Blood. 1999 May 15;93(10):3294-301. Click here to read Dynamic changes
in mouse hematopoietic stem cell numbers during aging. de ...

Source: Google Scholar

Effects Of Aging In Stem Cells
There is little disagreement that the body's maintenance and repair systems deteriorate with age, even as there is plenty of disagreement as to why. Stem cells combat the aging process by replenishing old or damaged cells-particularly in the skin, gut, and blood-with a fresh supply to maintain and repair tissue. Unfortunately, new evidence published in the open-access journal PLoS Biology suggests that this regenerative capacity also declines with age as stem cells acquire functional defects.

Stuart Chambers, Margaret Goodell, and their colleagues investigated the molecular mechanisms underlying aging of stem cells by looking at the gene expression profiles of aging hematopoietic stem cells (HSCs), the precursors of blood cells. They found that genes involved in the inflammatory and stress response became more active with age, while genes important for regulating gene expression and genomic integrity became less active. These results lend strong support to the notion that HSCs succumb to the wear and tear of aging, just like other cells, and shed light on the mechanisms of aging.
To study HSCs' regenerative capacity over time, Chambers et al. isolated HSCs from young (aged 2 months) and old (aged 21 months) mice and then transplanted either young or old cells into mice whose bone marrow cells had been destroyed by radiation. The young and old HSCs gave rise to new marrow cells at roughly the same pace 4 weeks after transplantation. But at 8 and 16 weeks after transplantation, the old HSCs' contributions had dropped considerably, suggesting that aging HSCs lose their repopulating capacity. Yet, because HSCs increased in number, overall blood production from HSCs remained stable.

The finding that genes involved in the inflammatory response are expressed more (called up-regulation) as HSCs age fits with evidence linking inflammation and aging in the kidney, brain, and arteries. It may also help explain why HSCs lose function. One of the up-regulated genes, P-selectin, encodes a cell surface adhesion molecule. Because transplanted HSCs depend on cell adhesion to colonize bone marrow properly, the researchers explain, inappropriate up-regulation of genes encoding P-selectin may interfere with this process.

The markedly reduced expression (or down-regulation) of genes involved in chromatin remodeling, an "epigenetic" regulator of gene expression, suggested that transcriptional activity might be dysregulated across the genome.

Though the dominant model attributes the physical effects of aging to an accretion of isolated genetic insults, these results link age-related decline to global mechanisms operating across the genome. In the researchers' "epigenetic view of aging," chromatin dysregulation provides a logical explanation for the numerous and diverse age-related changes observed at the molecular, cellular, and organismal levels. Over the normal course of aging, chromatin dysregulation leads to dysregulation of many genes, which in turn leads to a loss of normal cellular functions and a loss of growth regulation. These changes ultimately increase the risk of cancer, which, in many of its forms, increases dramatically with age. Future studies can investigate how epigenetic regulation, inflammation, and the stress response interact to better understand the molecular mechanisms of aging, and why so many of us face a high risk of cancer in our later years.

Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA, et al. (2007)
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation.
PLoS Biol 5(8): e201. doi:10.1371/journal.pbio.0050201.
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