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Recent News and Articles on the Keywords: early warning + kidney injury + acute  Related to the article below (Last Update: 5/5/2008)

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Source: Google News

Renal tubular cell injury and serum phospholipase A2 activity in acute pancreatitis. -
JM Gronroos, AJ Hietaranta, TJ Nevalainen - Br J Surg, 1992 - ncbi.nlm.nih.gov
... as an early warning of developing renal tubular cell injury was therefore investigated
in a prospective study of 31 consecutive patients suffering from acute ...

High-dose ifosfamide, carboplatin, and etoposide pharmacokinetics: correlation of plasma drug levels … -
JE Wright, A Elias, O Tretyakov, S Holden, J … - Cancer Chemotherapy and Pharmacology, 1995 - Springer
... suggests that plasma drug levels, analyzed early in the ... infusion of high-dose ICE,
provides warning of severe and poten- tially fatal renal injury. ...

Contrast-medium-induced acute renal failure. -
R Solomon - Kidney International, 1998 - pt.wkhealth.com
... Early studies suggested a role for the renin ... Drug Administration (FDA) issued a warning
cautioning against ... is determined by the microcirculation of the kidney. ...

[BOOK] Cope's Early Diagnosis of the Acute Abdomen -
W Silen, Z Cope - 2005 - books.google.com
... The early diagnosis of abdominal injuries, 242 22. ... More early cases will be diagnosed
by palpating the pelvic ... in the same region as the kidney; and though the ...

Noninvasive renal diagnostic studies.
NE Tolkoff-Rubin, RH Rubin, JV Bonventre - Clin Lab Med, 1988 - ncbi.nlm.nih.gov
... of acute renal failure from acute tubular necrosis ... pediatric age group; provide an
early warning of incipient ... an adequate screening test for renal injury due to ...

Early Warning of Rejection? -
JM Wellwood, BG Ellis, JH Hall, DR Robinson, AE … - British Medical Journal, 1973 - pubmedcentral.nih.gov
... Copyright notice. Early Warning of Rejection? ... Sequential analysis of urinary enzymes
in early diagnosis of parenchymal ... A possible mechanism of renal injury. ...

… production of antibodies after heart or lung transplantation should be regarded as an early warning … -
ML Rose - Journal of Heart and Lung Transplantation, 2004 - Elsevier
... or B-cell activity and as an early warning system for ... Although a number of early
studies have described ... HLA-antibody-mediated injury to renal allografts caused ...

Year in review in intensive care medicine. 2005. I. Acute respiratory failure and acute lung injury, … -
P Andrews, E Azoulay, M Antonelli, L Brochard, C … - Intensive Care Medicine, 2006 - Springer
... education, renal failure ... approach in critically ill patients fails to provide early
adequate information ... be a complementary approach serving as a warning of an ...

Perfusion quantitation in transplanted rat kidney by MRI with arterial spin labeling. -
JJ Wang, KS Hendrich, EK Jackson, ST Ildstad, DS … - Kidney International, 1998 - pt.wkhealth.com
... function. In this regard, renal blood flow may be a useful early warning
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Diagnosis of Renal Proximal Tubular Injury by Urinary Immunoassay for a Proximal Tubular Antigen, … -
NE Tolkoff-Rubin, RE Thompson, DJ Piper, WP Hansen … - Nephrology Dialysis Transplantation, 1987 - ERA-EDTA
... from those obtained from patients with acute tubular injury. ... weak URO-4 reactivity
in some kidney sections (NH ... which can serve as an early warning of impending ...

Source: Google Scholar

Early warning for acute kidney injury

Clinicians currently lack advance warning of acute kidney injury (AKI) for patients where kidney injury timing is unknown. Now paediatric research published in the open access journal, Critical Care, has identified a potential biomarker to predict AKI earlier than current tests, opening a vital window for prevention of this life-threatening condition.

A US team led by Michael Zappitelli, Kimberly Washburn and Stuart Goldstein from Baylor College of Medicine/Texas Children’s Hospital in Houston studied urinary neutrophil gelatinase associated lipocalin (uNGAL) levels in a prospective cohort of 140 critically ill children. They found that uNGAL was a good diagnostic marker for AKI development, with levels at least 6 times higher than control subjects.

The rise in uNGAL concentration occurred 48 hours before a jump in serum creatinine (SCr) levels. This is significant because SCr, currently the main AKI biomarker used in clinical settings, shows a reduction in renal function has already begun and even small SCr rises are independently associated with mortality. The authors suggest that uNGAL is a good diagnostic marker for early prediction of AKI when the timing of the kidney injury is unknown. However, they caution that urinary NGAL may not be a good predictor of AKI severity after a jump in SCr has occurred.

The authors found that children in the study with sepsis have higher uNGAL concentrations than those without sepsis, but the relationship between uNGAL and AKI was maintained. “The ultimate goal will be to have a biomarker panel in a urine dipstick format to rapidly assess biomarker threshold concentrations,” Zappitelli says. It remains to be seen whether the results will be duplicated in adults, in whom a higher degree of chronic inflammation may also affect uNGAL levels.

###

Article:
Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study
Michael Zappitelli, Kimberly K Washburn, Ayse A Arikan, Laura Loftis, Qing Ma, Prasad Devarajan, Chirag R Parikh and Stuart L Goldstein
Critical Care (in press)

During embargo, article available at: http://ccforum.com/imedia/2392894561405139_article.pdf?random=463330

After the embargo, article available at journal website: http://ccforum.com/

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central’s open access policy.

Article citation and URL available on request at press@biomedcentral.com on the day of publication

Author contact:
Ryan Rice (Press Office, Texas Children’s Hospital)
Phone: 832-824-2304 Email: rxrice@texaschildrenshospital.org

BioMed Central (http://www.biomedcentral.com) is an independent online publishing house committed to providing open access to peer-reviewed biological and medical research. This commitment is based on the view that immediate free access to research and the ability to freely archive and reuse published information is essential to the rapid and efficient communication of science.

BioMed Central currently publishes over 160 journals across biology and medicine. In addition to open-access original research, BioMed Central also publishes reviews, commentaries and other non-original-research content. Depending on the policies of the individual journal, this content may be open access or provided only to subscribers.

 
 
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