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Recent News and Articles on the Keywords: cervical cancer + vaccine targets + vaccine  Related to the article below (Last Update: 5/5/2008)

One jab everyone should get behind
The Nelson Mail, New Zealand -
It is estimated that the programme will eventually stop 30 women a year dying from cervical cancer. There the argument should end. A proven vaccine against ...
Vaccine is welcomed 'if it's safe' Gisborne Herald
all 6 news articles »
HPV vaccine available for Grade 6 girls
CTV Winnipeg, Canada - May 1, 2008
Manitoba's Chief Medical Officer of Health said the vaccine counters the leading cause of cervical cancer. "The vast majority - probably 99 per cent - of ...
Anti-cancer vaccine is just the jab
Coventry Telegraph, UK - Apr 29, 2008
Every year, about 1000 women die from cervical cancer. It's estimated that the simple jab could save hundreds of those women because it targets the virus ...
Dealing Cervical Cancer a Knockout Blow
U.S. News & World Report, DC - Apr 18, 2008
But doctors now believe they are poised to deal cervical cancer a knockout blow, thanks to the HPV vaccine. In the nearly two years that have followed its ...
Clark putting $150m into cancer vaccine
New Zealand Herald, New Zealand - May 1, 2008
The vaccine - likely to be Gardasil - targets human papilloma virus (HPV), a common sexually transmitted infection linked with cervical cancer, ...
1 in 5 parents refuse daughters' cervical cancer jab
guardian.co.uk, UK - Apr 24, 2008
A trial of the new cervical cancer vaccine programme for schoolgirls across the country has encountered opposition from parents, with 20% refusing to give ...
?Cautious Optimism? Over Cancer Vaccine
WebMD - Apr 14, 2008
A second vaccine curbed or stopped the growth of tumors in women with cervical cancer. Unlike the vaccine that helps prevent cervical cancer in healthy ...
Girls may get mass anti-cancer jabs
New Zealand Herald, New Zealand - Apr 13, 2008
The ministry is negotiating with GlaxoSmithKline and CSL, which each supply a vaccine that targets strains of HPV associated with 70 per cent of cervical ...
Avesthagen partners with ShigaMediX to develop vaccines for ...
India PRwire (Press Release), India - Apr 25, 2008
The partnership will result in developing a novel therapeutic vaccine against HPV (Human Papilloma Virus), which causes cervical cancer. ...
NL leader in cervical cancer research
Labradorian, Canada - Apr 28, 2008
The vaccine is the most effective primary cervical cancer prevention strategy. The HPV vaccines cannot replace screening because the vaccine only targets ...
Source: Google News

… Type 16 E7 Peptide DNA Fused with Heat Shock Protein DNA as a Potential Vaccine for Cervical Cancer -
DW Liu, YP Tsao, JT Kung, YA Ding, HK Sytwu, X … - Journal of Virology, 2000 - Am Soc Microbiol
... E/T, effector/target. ... vaccinia virus expressing human papillomavirus proteins for
immunotherapy of cervical cancer. Vaccine 14:1485-1494[CrossRef][Medline]. ...

… human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a … -
LL Villa, RLR Costa, CA Petta, RP Andrade, KA Ault … - Lancet Oncology, 2005 - Elsevier
... 16 and 18 cause about 70% of cervical cancer and high-grade cervical intraepithelial
neoplasia ... for assessment of a quadrivalent HPV vaccine that targets ...

Vaccination against human papillomavirus infection: a new paradigm in cervical cancer control -
EL Franco, DM Harper - Vaccine, 2005 - Elsevier
... as sufficient evidence for subsequent vaccine candidates? ... the definition of the target
population to ... and health care providers that cervical cancer should be ...

Potential Health and Economic Impact of Adding a Human Papillomavirus Vaccine to Screening Programs -
SL Kulasingam, ER Myers - JAMA, 2003 - Am Med Assoc
... were cancer survivors, or had died due to cervical cancer. ... high-risk types that the
vaccine targets as a ... the assumption that an effective vaccine targeted at a ...

Quadrivalent human papillomavirus vaccine. Recommendations of the Advisory Committee on Immunization … -
LE Markowitz, EF Dunne, M Saraiya, HW Lawson, H … - Recommendations and Reports - popline.org
... Vaccine can be administered as young as age 9 ... females should have cervical cancer
screening as ... Recommendations Epidemiologic Methods Target Population Children ...

Human papillomarivus vaccines for cervical cancer -
RW Tindle - Current Opinion in Immunology, 1996 - Elsevier
... validate a prophylactic vaccine approach for cervical cancer. ... and what the readout
for vaccine efficacy will ... existing HPV infection should target cell-mediated ...

The Theoretical Population-Level Impact of a Prophylactic Human Papilloma Virus Vaccine. -
JP Hughes, GP Garnett, L Koutsky - Epidemiology, 2002 - epidem.com
... the technologies available in the control of cervical cancer. ... the predicted efficacy
of various vaccine strategies remains ... as a strategy that targets both sexes ...

Dendritic cell-based tumor vaccine for cervical cancer II: results of a clinical pilot study in 15 … -
A Ferrara, M Nonn, P Sehr, C Schreckenberger, M … - Journal of Cancer Research and Clinical Oncology, 2003 - Springer
... considered to be tumor-specific targets for immunotherapy. ... Results: The vaccine was
well-tolerated and no ... responses in a portion of late stage cervical cancer ...

A vaccine conjugate of'ISCAR'immunocarrier and peptide epitopes of the E7 cervical cancer-associated … -
RW Tindle, S Croft, K Herd, K Malcolm, AF Geczy, T … - Clinical and Experimental Immunology, 1995 - pubmedcentral.nih.gov
... to stimulate immune responses to endogenously processed target antigens (eg ... Vaccine. ...
help for several E7 B-cell epitopes from cervical cancer-associated human ...

… Proteolysis Is Essential for Eradication of Established Tumors by an Epitope String DNA Vaccine 1 -
MP Velders, S Weijzen, GL Eiben, AG Elmishad, PM … - The Journal of Immunology, 2001 - Am Assoc Immnol
... A DNA-based vaccine would be a good candidate ... high risk papillomaviruses involved
in cervical cancer, the use of ... E7 are present in all cervical carcinoma cells ...

Source: Google Scholar

Worldwide distribution of cervical cancer virus is consistent with vaccine targets

CHAPEL HILL – The variety of human papilloma viruses that cause invasive cervical cancer cases worldwide are largely consistent across continents, according to a new study from the University of North Carolina at Chapel Hill. 

This finding means that prophylactic vaccines currently available against these two most prevalent types of human papillomavirus (HPV) – which can cause cervical cancer – could prevent about 70 percent of invasive cervical cancer (ICC) cases around the world, the researchers found.

“Our data confirm that HPV types 16 and 18 are the most common in invasive cancer and strengthen the data on the estimated number of cases that could be prevented with vaccination,” said lead study author Jennifer Smith, Ph.D., a research assistant professor of epidemiology in the UNC School of Public Health and a member of the UNC Lineberger Comprehensive Cancer Center. “As a result of this analysis, we now have additional information about other high-risk HPV types that cause invasive cancer to target for future HPV vaccine development.”

The results were published in the Aug. 1, 2007, issue of the International Journal of Cancer.

HPV is a sexually transmitted virus that can cause high-grade cervical lesions, increasing a woman’s risk of developing invasive cervical cancer. There are approximately 14 high-risk types of HPV that cause invasive cervical cancer, Smith explains. The two most common types are 16 and 18, named for their genetic patterns. These virus types are responsible for about 70 percent of invasive cervical cancer and 50 percent of high-grade lesions worldwide, the study shows.

To estimate the prevalence of different virus types in cancer, the researchers conducted a meta-analysis of data on the distribution of HPV infection in more than 14,000 invasive and 7,000 high-grade cases throughout the world. A meta-analysis combines statistics from smaller studies to develop information with greater statistical significance.

The scientists reported that ICC HPV16 was the most common, and HPV18 the second most-common type in all continents. Combined HPV 16/18 prevalence among ICC cases was slightly higher in Europe, North America and Australia, from 74 to 77 percent, than in Africa, Asia and South/Central America, where the rates were between 65 and 70 percent. Data on HPV-typed ICC and high-grade lesions were particularly scarce from large regions of Africa and Central Asia.

Gardasil, a Merck & Co. vaccine approved last year by the Food and Drug Administration, protects against HPV 16 and 18. A similar vaccine developed by GlaxoSmithKline also protects against these types of HPV.

“While having these vaccines represents a significant step forward, HPV-vaccinated women will need to receive clear messages that they still need to obtain their recommended Pap smears for cervical cancer prevention, given that HPV vaccines will not prevent all invasive cancer or high-grade lesions,” Smith said.
 
Other study authors include: Brooke Hoots and Jessica Keys, in the UNC School of Public Health’s department of epidemiology; Lisa Lindsay of GlaxoSmithKline Biologicals in Belgium; Silvia Franceschi and Gary Clifford, with the International Agency for Research on Cancer in Lyon, France; and Rachel Winer, at the University of Washington.

Note: Jennifer Smith may be reached at (919) 966-7450 or jsssmith@email.unc.edu.

School of Public Health contact: Ramona DuBose (919) 966-7467 or ramona_dubose@unc.edu
UNC Lineberger contact: Dianne Shaw (919) 966-5905 or dgs@med.unc.edu
News Services contact: Clinton Colmenares (919) 843-1991 or clinton_colmenares@unc.edu
 
 
 
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