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Recent News and Articles on the Keywords: new treatment + esrf lightsource + new  Related to the article below (Last Update: 5/5/2008)

NIMS? Acceleration Platform to be Investigated as a New Treatment ...
Business Wire (press release), CA -
... grant-in-aid from April 2008 to March 2011 for a study dealing with NIMS? flagship product, Exer-Rest?, as a new treatment for cardiovascular disease. ...
Two new treatment plants address water concerns
Las Cruces Sun-News, NM -
One treatment plant will mark a new direction for the community of Do?a Ana, while the other will be a first for the region. The process of site selection ...
New Free Online Physician Locator for People Addicted to Alcohol
PR Newswire (press release), NY -
To help facilitate this process, we have developed a new treatment locator. This new 24/7 free locator also connects patients to counselors/therapists and ...

Health Newstrack
Aussies find new treatment for AIDS
PRESS TV, Iran - May 3, 2008
Australian scientists have found a new HIV treatment that trains the body's immune system cells to recognize the AIDS virus quicker. ...
New immune treatment may control AIDS virus Reuters UK
New 'OPAL Therapy' for reating HIV infection Hindu
Study: AIDS Treatment Shows Promise in Monkeys FOXNews
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Press of Atlantic City
For those who are brave, drug trials offer hope
Press of Atlantic City, NJ -
Phase III trials assign patients to two groups randomly, to compare a new treatment against the current standard. If you're in the investigational group, ...

Durango Herald
Purgatory district residents to vote on bond for treatment plant
Durango Herald, CO - May 4, 2008
DMR will dedicate 30 acres for the new community park and is donating the land where the new treatment plant would be located, east of and at a lower ...
Cancer center aims to be the area?s best
Brazosport Facts (subscription), TX -
Hospital officials plan to begin construction on $1 million of new office and clerical space, which along with the new treatment room that has a tab of $1.4 ...

Manx Radio
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And thanks to a new water treatment works it is something we can look forward to for years to come. Lieutenant Governor Vice Admiral Sir Paul Haddacks ...
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Startup looks at eye treatment
Roanoke Times, VA - May 4, 2008
A Roanoke company is trying to devise a new treatment. The tiny bottle holds topical eyedrops that someday could radically transform the treatment of ...
Bay Point water provider to start using new treatment process
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Trihalomethanes are a byproduct of the water-treatment process formed when organic material, like decaying vegetation commonly found in lakes and reservoirs ...
Source: Google News

X-ray waveguide as a new tool for 100 nm spatially resolved x-ray strain analysis -
C Giannini, L De Caro, S Lagomarsino, A Cedola, S … - J. Phys. D: Appl. Phys, 2001 - iop.org
... profiles based on an analytical treatment of the ... have shown interest in exploring
new methodologies of ... line ID13 at the synchrotron light source ESRF (Grenoble ...

Adding synchrotron radiation to infrared microspectroscopy: what's new in biomedical applications? -
P Dumas, GD Sockalingum, J Sul?-Suso - Trends in Biotechnology, 2007 - Elsevier
... facilities provide assistance for data treatment, including software ... are much
appreciated by the new comers in ... at the SRS (Daresbury, UK), ESRF (Grenoble, France ...

Commissioning of new synchrotron radiation facilities
E Courses, T Surveys - Particle Accelerator Conference, 2007. PAC. IEEE, 2007 - ieeexplore.ieee.org
... source storage rings at the ESRF [33], APS [34 ... strong nonlinearities that need
especially careful treatment. ... Proceedings of PAC07, Albuquerque, New Mexico, USA ...
-

[PDF] COMMISSIONING OF NEW SYNCHROTRON RADIATION FACILITIES -
Z Zhao - Diamond - accelconf.web.cern.ch
... source storage rings at the ESRF [33], APS [34 ... strong nonlinearities that need
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[BOOK] Progress in Ultra-Short Electromagnetic Pulse Technology: A New Frontier in Physics -
JF Eloy - 2002 - books.google.com
... processes and nuclear stability for nuclear waste treatment and storage ... to focus
my interest on the new field of ... et al., D.Cornuejols, and O. Mathon at ESRF. ...

Crystal clear
F Size, DF Size - Current Biology, 2006 - current-biology.com
... European Synchrotron Radiation Facility (ESRF) in Grenoble ... allow adventurous research
into new problems and in ... assistance of structure-based drug design programs ...

Crystal clear -
M Gross - Current Biology, 2006 - current-biology.com
... European Synchrotron Radiation Facility (ESRF) in Grenoble ... allow adventurous research
into new problems and in ... assistance of structure-based drug design programs ...

[PDF] PROPERTIES OF NEW YORK/NEW JERSEY HARBOR SEDIMENTS. -
KW JONES, H FENG, EA STERN, U NEUHAEUSLER, J OSAN, … - Conference: XL ZAKOPANE SCHOOL OF PHYSICS, 2005 - pubs.bnl.gov
... Synchrotron Radiation Facility (ESRF) at Grenoble, France ... taken from Newtown Creek
in New York City (40 ... creation 0.f beneficial use products following treatment. ...

CURRENT PROGRESS AND FUTURE DEVELOPMENTS IN SYCHROTRON RADIATION INSTRUMENTATION FOR THE ESRF …
D HAUSERMA - High Pressure Research, 1992 - informaworld.com
... Orsay, France Large volume Multipole wiggler National Synchrotron Light Source,
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[PDF] X-ray Characterization of Cement-based Materials: Previous Applications & New Opportunities -
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... based Materials: Previous Applications & New Opportunities ... phase-contrast
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Source: Google Scholar

ESRF lightsource helps tailoring new treatments against asthma

PRESS RELEASE- Researchers from Sweden and France have deciphered the crystal structure of a human membrane protein which has a major influence on the development of asthma. They used the highly automated ESRF macromolecular crystallography experimental stations (beamlines) to determine the structure of this pharmaceutically important protein, only the third human membrane protein to be solved. The scientists now believe that their work will enable the development of new and better therapeutic drugs targeting inflammation of the respiratory tract.

Asthma affects 300 million people worldwide and, according to World Health Organization, it killed 255 000 people in 2005. Asthma attacks are caused by an acute inflammatory reaction in the airways, a reaction that is largely due to actions of LTC4 synthase (an enzyme which catalyzes a synthesis process). For this reason asthma medicines often aim to block the downstream effects of LTC4 synthase.

However, there is a need for new pharmaceutical alternatives, since not all patients respond to the existing medicines. Thanks to the research partly carried out at the European Synchrotron Radiation Facility (ESRF), it is now possible to tailor new molecules that can block the LTC4 synthase. “I believe this breakthrough will speed up drug discovery against this disease”, explains Andrew McCarthy, one of the researchers in the team.

Scientists from the Karolinska Institute and the University of Stockholm in Sweden, together with colleagues from the European Molecular Biology Laboratory in France have solved the three dimensional structure of the LTC4 synthase at 2.0 Ångstrom resolution . The protein has three identical subunits, each consisting of four helical structures that span the membrane. The structure finally allows the exact position and characteristics of the active sites, where activating or blocking molecules can bind, to be identified.

The study of this protein at the ESRF proved a challenge for the team. The crystallization of membrane proteins is quite a complex process and even more challenging if they are human. So far only three human membrane proteins have been structurally characterized. The team carried out experiments at the ESRF to screen crystals several times before finally being able to determine the 3D structure.

Structure of LTC4 synthase

LTC4 synthase overall structure. a) Left, front view of LTC4 synthase protomer in ribbon representation showing helices 1–5 in successive colouring. The entire LTC4 synthase polypeptide, except for the last residue (the last four in the GSH-complexed structure), can be traced in the electron density maps. Right, the homotrimer with protomers coloured orange, green and blue. Bound glutathione, indicating the position of the active site, is in ball and stick representation. Approximate membrane positions indicated by blue lines. b) Cytosolic view of the trimer, showing the position of the three active sites with loop 1 covering each binding pocket. Glutathione is shown in ball and stick representation together with modelled detergent (DDM). Image credit: D. Martinez Molina.

 

Membrane proteins- an open door to new pharmaceuticals

The new results can lead the way for the development of new and more effective medications against other diseases. Some 40 % of the proteins of interest for pharmaceutical developments are membrane proteins.

Until now detailed structural information on these proteins has been absent, and therefore it has been difficult to fully understand their function. The present study is likely to lead the way for the determination of structures of other human membrane proteins. Unravelling the secrets of more membrane protein structures will help understand fundamental processes that take place in the cell membranes.

Reference

"Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase", Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggström JZ, Nordlund P, Nature AOP 15 july 2007.

For more information, please contact Montserrat Capellas ( email or +33 (0)476882663).

 
 
 
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